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Human Brain Mapping - 2022 - Schl ter - Neurite density imaging in amygdala nuclei reveals interindividual differences in.pdf 2,23MB
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1000 Titel
  • Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism
1000 Autor/in
  1. Schlüter, Caroline |
  2. Fraenz, Christoph |
  3. Friedrich, Patrick |
  4. Güntürkün, Onur |
  5. Genc, Erhan |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-20
1000 Erschienen in
1000 Quellenangabe
  • 43(6):2051-2063
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/hbm.25775 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933246/ |
1000 Ergänzendes Material
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933246/# |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Neuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala’s structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites. We, therefore, acquired brain images from 221 healthy participants using advanced multi-shell diffusion-weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high-resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO-PI-R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism-related disorders like depression.
1000 Sacherschließung
lokal NODDI
lokal amygdala nuclei
lokal neurite density
lokal neuroticism
lokal depression
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3684-3096|https://frl.publisso.de/adhoc/uri/RnJhZW56LCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/RnJpZWRyaWNoLCBQYXRyaWNr|https://orcid.org/0000-0003-4173-5233|https://orcid.org/0000-0001-6514-5479
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Projekt DEAL |
1000 Fördernummer
  1. 316803389; GU 227/16-1
  2. -
1000 Förderprogramm
  1. SFB 1280 project A03
  2. Open access funding
1000 Dateien
  1. Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm SFB 1280 project A03
    1000 Fördernummer 316803389; GU 227/16-1
  2. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6434745.rdf
1000 Erstellt am 2022-08-29T14:12:37.635+0200
1000 Erstellt von 254
1000 beschreibt frl:6434745
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Wed Aug 31 12:22:32 CEST 2022
1000 Objekt bearb. Wed Aug 31 12:22:19 CEST 2022
1000 Vgl. frl:6434745
1000 Oai Id
  1. oai:frl.publisso.de:frl:6434745 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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