Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination

  1. Urlaub, Doris
  2. Wolfsdorff, Natalie
  3. Hoffmann, Jan-Erik
  4. Dorok, Stefanie
  5. Hoffmann, Markus
  6. Anft, Moritz
  7. Pieris, Naomi
  8. Günther, Patrick
  9. Schaaf, Bernhard
  10. Cassens, Uwe
  11. Bröde, Peter ORCID logo
  12. Claus, Maren ORCID logo
  13. Picard, Lea Katharina ORCID logo
  14. Wingert, Sabine
  15. Backes, Simone
  16. Durak, Deniz
  17. Babel, Nina
  18. Pöhlmann, Stefan
  19. Renken, Frank
  20. Raunser, Stefan
  21. Watzl, Carsten ORCID logo

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Eur J Immunol - 2022 - Urlaub - Neutralizing antibody responses 300 days after SARS‐CoV‐2 infection and induction of high.pdf 295,32KB
WeightNameValue
1000 Titel
  • Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination
1000 Autor/in
  1. Urlaub, Doris |
  2. Wolfsdorff, Natalie |
  3. Hoffmann, Jan-Erik |
  4. Dorok, Stefanie |
  5. Hoffmann, Markus |
  6. Anft, Moritz |
  7. Pieris, Naomi |
  8. Günther, Patrick |
  9. Schaaf, Bernhard |
  10. Cassens, Uwe |
  11. Bröde, Peter |
  12. Claus, Maren |
  13. Picard, Lea Katharina |
  14. Wingert, Sabine |
  15. Backes, Simone |
  16. Durak, Deniz |
  17. Babel, Nina |
  18. Pöhlmann, Stefan |
  19. Renken, Frank |
  20. Raunser, Stefan |
  21. Watzl, Carsten |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-03-05
1000 Erschienen in
1000 Quellenangabe
  • 52(5):810-815
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/eji.202149758 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087412/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/10.1002/eji.202149758#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Neutralizing antibodies against SARS-CoV-2 are important to protect against infection and/or disease. Using an assay todetect antibodies directed against the receptor binding domain (RBD) of SARS-CoV-2 Spike, we identified individuals withSARS-CoV-2 infection after an outbreak at a local health institution. All but one COVID-19 patient developed detectableanti-RBD antibodies and 77% had virus neutralizing antibody titers of>1:25. Antibody levels declined slightly over time.However, we still detected virus neutralizing antibody titers in 64% of the COVID-19 patients at>300 days after infection,demonstrating durability of neutralizing antibody levels after infection. Importantly, full COVID-19 vaccination of theseindividuals resulted in higher antibody titers compared to fully vaccinated individuals in the absence of prior infection.These data demonstrate long-lived antibody-mediated immunity after SARS-CoV-2 infection, and a clear benefit of twovaccine doses for recovered individuals.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal vaccines
lokal SARS-CoV-2
lokal antibody titers
lokal waning immunity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VXJsYXViLCBEb3Jpcw==|https://frl.publisso.de/adhoc/uri/V29sZnNkb3JmZiwgTmF0YWxpZQ==|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIEphbi1Fcmlr|https://frl.publisso.de/adhoc/uri/RG9yb2ssIFN0ZWZhbmll|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIE1hcmt1cw==|https://frl.publisso.de/adhoc/uri/QW5mdCwgTW9yaXR6|https://frl.publisso.de/adhoc/uri/UGllcmlzLCBOYW9taQ==|https://frl.publisso.de/adhoc/uri/R8O8bnRoZXIsIFBhdHJpY2s=|https://frl.publisso.de/adhoc/uri/U2NoYWFmLCBCZXJuaGFyZA==|https://frl.publisso.de/adhoc/uri/Q2Fzc2VucywgVXdl|https://orcid.org/0000-0001-8107-704X|https://orcid.org/0000-0001-8732-0645|https://orcid.org/0000-0002-3969-9061|https://frl.publisso.de/adhoc/uri/V2luZ2VydCwgU2FiaW5l|https://frl.publisso.de/adhoc/uri/QmFja2VzLCBTaW1vbmU=|https://frl.publisso.de/adhoc/uri/RHVyYWssIERlbml6|https://frl.publisso.de/adhoc/uri/QmFiZWwsIE5pbmE=|https://frl.publisso.de/adhoc/uri/UMO2aGxtYW5uLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/UmVua2VuLCBGcmFuaw==|https://frl.publisso.de/adhoc/uri/UmF1bnNlciwgU3RlZmFu|https://orcid.org/0000-0001-5195-0995
1000 Label
1000 Förderer
  1. Volkswagen Foundation |
  2. Projekt DEAL |
1000 Fördernummer
  1. 98 579
  2. -
1000 Förderprogramm
  1. -
  2. Open Access Funding
1000 Dateien
  1. Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination
    Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Volkswagen Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 98 579
  2. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access Funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6434790.rdf
1000 Erstellt am 2022-09-02T13:17:42.027+0200
1000 Erstellt von 254
1000 beschreibt frl:6434790
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2022-09-07T13:51:10.303+0200
1000 Objekt bearb. Wed Sep 07 13:50:56 CEST 2022
1000 Vgl. frl:6434790
1000 Oai Id
  1. oai:frl.publisso.de:frl:6434790 |
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