COVID-19 in Patients with Pulmonary Hypertension A National Prospective Cohort Study

  1. Montani, David ORCID logo
  2. Certain, Marie-Caroline
  3. Weatherald, Jason ORCID logo
  4. Jaïs, Xavier
  5. Bulifon, Sophie
  6. Noel-Savina, Elise
  7. Nieves, Ana
  8. Renard, Sébastien
  9. Traclet, Julie
  10. Bouvaist, Hélène
  11. Riou, Marianne
  12. de Groote, Pascal
  13. Moceri, Pamela
  14. Bertoletti, Laurent
  15. Favrolt, Nicolas
  16. Guillaumot, Anne
  17. Jutant, Etienne-Marie ORCID logo
  18. Beurnier, Antoine
  19. Boucly, Athénaïs ORCID logo
  20. Ebstein, Nathan
  21. Jevnikar, Mitja
  22. Pichon, Jérémie
  23. Keddache, Sophia
  24. Preda, Mariana
  25. Roche, Anne
  26. Solinas, Sabina
  27. Seferian, Andrei
  28. Reynaud-Gaubert, Martine
  29. Cottin, Vincent ORCID logo
  30. Savale, Laurent
  31. Humbert, Marc ORCID logo
  32. Sitbon, Olivier
  33. French PH Network PULMOTENSION Investigators

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WeightNameValue
1000 Titel
  • COVID-19 in Patients with Pulmonary Hypertension A National Prospective Cohort Study
1000 Autor/in
  1. Montani, David |
  2. Certain, Marie-Caroline |
  3. Weatherald, Jason |
  4. Jaïs, Xavier |
  5. Bulifon, Sophie |
  6. Noel-Savina, Elise |
  7. Nieves, Ana |
  8. Renard, Sébastien |
  9. Traclet, Julie |
  10. Bouvaist, Hélène |
  11. Riou, Marianne |
  12. de Groote, Pascal |
  13. Moceri, Pamela |
  14. Bertoletti, Laurent |
  15. Favrolt, Nicolas |
  16. Guillaumot, Anne |
  17. Jutant, Etienne-Marie |
  18. Beurnier, Antoine |
  19. Boucly, Athénaïs |
  20. Ebstein, Nathan |
  21. Jevnikar, Mitja |
  22. Pichon, Jérémie |
  23. Keddache, Sophia |
  24. Preda, Mariana |
  25. Roche, Anne |
  26. Solinas, Sabina |
  27. Seferian, Andrei |
  28. Reynaud-Gaubert, Martine |
  29. Cottin, Vincent |
  30. Savale, Laurent |
  31. Humbert, Marc |
  32. Sitbon, Olivier |
  33. French PH Network PULMOTENSION Investigators |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-09-01
1000 Erschienen in
1000 Quellenangabe
  • 206(5):573-583
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1164/rccm.202112-2761OC |
1000 Ergänzendes Material
  • https://www.atsjournals.org/doi/suppl/10.1164/rccm.202112-2761OC |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • RATIONALE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with pulmonary endothelial dysfunction. There are limited data available on the outcomes of coronavirus disease (COVID-19) in patients with pulmonary hypertension (PH), a disease characterized by pulmonary endothelial dysfunction. OBJECTIVES: To describe characteristics and outcomes of patients with precapillary PH and COVID-19. METHODS: We prospectively collected characteristics, management, and outcomes of adult patients with precapillary PH in the French PH network who had COVID-19 between February 1, 2020, and April 30, 2021. Clinical, functional, and hemodynamic characteristics of PH before COVID-19 were collected from the French PH registry. MEASUREMENTS AND MAIN RESULTS: A total of 211 patients with PH (including 123 with pulmonary arterial hypertension, 47 with chronic thromboembolic PH, and 41 with other types of PH) experienced COVID-19, and 40.3% of them were outpatients, 32.2% were hospitalized in a conventional ward, and 27.5% were in an ICU. Among hospitalized patients (n = 126), 54.0% received corticosteroids, 37.3% high-flow oxygen, and 11.1% invasive ventilation. Right ventricular and acute renal failure occurred in 30.2% and 19.8% of patients, respectively. Fifty-two patients (all hospitalized) died from COVID-19. Overall mortality was 24.6% (95% CI [confidence interval], 18.8-30.5) and in-hospital mortality 41.3% (95% CI, 32.7-49.9). Nonsurvivors were significantly older, more frequently male and suffering comorbidities (diabetes, chronic respiratory diseases, systemic hypertension, chronic cardiac diseases, and/or chronic renal failure), and had more severe PH at their most recent evaluation preceding COVID-19 diagnosis (in terms of functional class and 6-minute-walk distance; all P, 0.05). Use of pulmonary arterial hypertension therapy was similar between survivors and nonsurvivors. CONCLUSIONS: COVID-19 in patients with precapillary PH was associated with a high in-hospital mortality. The typical risk factors for severe COVID-19 and severity of PH were associated with mortality in this population.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal pulmonary aterial hypertension
lokal pulmonary hypertension
lokal outcomes
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9358-6922|https://frl.publisso.de/adhoc/uri/Q2VydGFpbiwgTWFyaWUtQ2Fyb2xpbmU=|https://orcid.org/0000-0002-0615-4575|https://frl.publisso.de/adhoc/uri/SmHDr3MsIFhhdmllcg==|https://frl.publisso.de/adhoc/uri/QnVsaWZvbiwgU29waGll|https://frl.publisso.de/adhoc/uri/Tm9lbC1TYXZpbmEsIEVsaXNl|https://frl.publisso.de/adhoc/uri/TmlldmVzLCBBbmE=|https://frl.publisso.de/adhoc/uri/UmVuYXJkLCBTw6liYXN0aWVu|https://frl.publisso.de/adhoc/uri/VHJhY2xldCwgSnVsaWU=|https://frl.publisso.de/adhoc/uri/Qm91dmFpc3QsIEjDqWzDqG5l|https://frl.publisso.de/adhoc/uri/UmlvdSwgTWFyaWFubmU=|https://frl.publisso.de/adhoc/uri/ZGUgR3Jvb3RlLCBQYXNjYWw=|https://frl.publisso.de/adhoc/uri/TW9jZXJpLCBQYW1lbGE=|https://frl.publisso.de/adhoc/uri/QmVydG9sZXR0aSwgTGF1cmVudA==|https://frl.publisso.de/adhoc/uri/RmF2cm9sdCwgTmljb2xhcw==|https://frl.publisso.de/adhoc/uri/R3VpbGxhdW1vdCwgQW5uZQ==|https://orcid.org/0000-0002-1374-1890|https://frl.publisso.de/adhoc/uri/QmV1cm5pZXIsIEFudG9pbmU=|https://orcid.org/0000-0001-6246-5557|https://frl.publisso.de/adhoc/uri/RWJzdGVpbiwgTmF0aGFu|https://frl.publisso.de/adhoc/uri/SmV2bmlrYXIsIE1pdGph|https://frl.publisso.de/adhoc/uri/UGljaG9uLCBKw6lyw6ltaWU=|https://frl.publisso.de/adhoc/uri/S2VkZGFjaGUsIFNvcGhpYQ==|https://frl.publisso.de/adhoc/uri/UHJlZGEsIE1hcmlhbmE=|https://frl.publisso.de/adhoc/uri/Um9jaGUsIEFubmU=|https://frl.publisso.de/adhoc/uri/U29saW5hcywgU2FiaW5h|https://frl.publisso.de/adhoc/uri/U2VmZXJpYW4sIEFuZHJlaQ==|https://frl.publisso.de/adhoc/uri/UmV5bmF1ZC1HYXViZXJ0LCBNYXJ0aW5l|https://orcid.org/0000-0002-5591-0955|https://frl.publisso.de/adhoc/uri/U2F2YWxlLCBMYXVyZW50|https://orcid.org/0000-0003-0703-2892|https://frl.publisso.de/adhoc/uri/U2l0Ym9uLCBPbGl2aWVy|https://frl.publisso.de/adhoc/uri/RnJlbmNoIFBIIE5ldHdvcmsgUFVMTU9URU5TSU9OIEludmVzdGlnYXRvcnM=
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