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1000 Titel
  • Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test
1000 Autor/in
  1. Montag, Dirk |
  2. Pelz, Laura |
  3. Rathjen, Fritz G. |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-01-06
1000 Erschienen in
1000 Quellenangabe
  • 18(1):e0280133
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0280133 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821459/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280133#sec010 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The brain- and testis-specific Ig superfamily protein (BT-IgSF, also termed IgSF11) is a homotypic cell adhesion protein. In the nervous system, BT-IgSF regulates the stability of AMPA receptors in the membrane of cultured hippocampal neurons, modulates the connectivity of chandelier cells and controls gap junction-mediated astrocyte-astrocyte communication. Here, we performed behavioral tests in BT-IgSF-deficient mice. BT-IgSF-deficient mice were similar to control littermates with respect to their reflexes, motor coordination and gating, and associative learning. However, BT-IgSF-deficient mice displayed an increased tendency to stay in the central illuminated areas in the open field and O-Maze paradigms suggesting reduced anxiety or increased scotophobia (fear of darkness). Although BT-IgSF-deficient mice initially found the platform in the water maze their behavior was compromised when the platform was moved, indicating reduced behavioral flexibility. This deficit was overcome by longer training to improve their spatial memory. Furthermore, male BT-IgSF-deficient mice displayed increased aggression towards an intruder. Our results show that specific behaviors are modified by the lack of BT-IgSF and demonstrate a contribution of BT-IgSF to network functions.
1000 Sacherschließung
lokal Genetically modified animals
lokal Hippocampus
lokal Aggression
lokal Learning
lokal Neurons
lokal Astrocytes
lokal Animal behavior
lokal Mice
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  1. https://orcid.org/0000-0002-4964-1330|https://frl.publisso.de/adhoc/uri/UGVseiwgTGF1cmE=|https://frl.publisso.de/adhoc/uri/UmF0aGplbiwgRnJpdHogRy4=
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1000 Erstellt am 2023-01-09T11:10:40.041+0100
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