Association of polygenic risk scores and hair cortisol with mental health trajectories during COVID lockdown

  1. Ahrens, Kira F. ORCID logo
  2. Neumann, Rebecca J.
  3. Von Werthern, Nina M.
  4. Kranz, Thorsten M.
  5. Kollmann, Bianca ORCID logo
  6. Mattes, Björn ORCID logo
  7. Puhlmann, Lara ORCID logo
  8. Weichert, Danuta
  9. Lutz, Beat
  10. Basten, Ulrike
  11. Fiebach, Christian ORCID logo
  12. Wessa, Michele
  13. Kalisch, Raffael ORCID logo
  14. Lieb, Klaus
  15. Chiocchetti, Andreas G.
  16. Tuescher, Oliver ORCID logo
  17. Reif, Andreas ORCID logo
  18. Plichta, Michael M.

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1000 Titel
  • Association of polygenic risk scores and hair cortisol with mental health trajectories during COVID lockdown
1000 Autor/in
  1. Ahrens, Kira F. |
  2. Neumann, Rebecca J. |
  3. Von Werthern, Nina M. |
  4. Kranz, Thorsten M. |
  5. Kollmann, Bianca |
  6. Mattes, Björn |
  7. Puhlmann, Lara |
  8. Weichert, Danuta |
  9. Lutz, Beat |
  10. Basten, Ulrike |
  11. Fiebach, Christian |
  12. Wessa, Michele |
  13. Kalisch, Raffael |
  14. Lieb, Klaus |
  15. Chiocchetti, Andreas G. |
  16. Tuescher, Oliver |
  17. Reif, Andreas |
  18. Plichta, Michael M. |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-09-21
1000 Erschienen in
1000 Quellenangabe
  • 12(1):396
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-022-02165-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490720/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41398-022-02165-9#Sec19 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The COVID-19 pandemic is a global stressor with inter-individually differing influences on mental health trajectories. Polygenic Risk Scores (PRSs) for psychiatric phenotypes are associated with individual mental health predispositions. Elevated hair cortisol concentrations (HCC) and high PRSs are related to negative mental health outcomes. We analyzed whether PRSs and HCC are related to different mental health trajectories during the first COVID lockdown in Germany. Among 523 participants selected from the longitudinal resilience assessment study (LORA), we previously reported three subgroups (acute dysfunction, delayed dysfunction, resilient) based on weekly mental health (GHQ-28) assessment during COVID lockdown. DNA from blood was collected at the baseline of the original LORA study (n = 364) and used to calculate the PRSs of 12 different psychopathological phenotypes. An explorative bifactor model with Schmid-Leiman transformation was calculated to extract a general genetic factor for psychiatric disorders. Hair samples were collected quarterly prior to the pandemic for determining HCC (n = 192). Bivariate logistic regressions were performed to test the associations of HCC and the PRS factors with the reported trajectories. The bifactor model revealed 1 general factor and 4 sub-factors. Results indicate a significant association between increased values on the general risk factor and the allocation to the acute dysfunction class. The same was found for elevated HCC and the exploratorily tested sub-factor “childhood-onset neurodevelopmental disorders”. Genetic risk and long-term cortisol secretion as a potential indicator of stress, indicated by PRSs and HCC, respectively, predicted different mental health trajectories. Results indicate a potential for future studies on risk prediction.
1000 Sacherschließung
lokal Human behaviour
lokal Predictive markers
lokal Clinical genetics
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-3249-0409|https://frl.publisso.de/adhoc/uri/TmV1bWFubiwgUmViZWNjYSBKLg==|https://frl.publisso.de/adhoc/uri/Vm9uIFdlcnRoZXJuLCBOaW5hIE0u|https://frl.publisso.de/adhoc/uri/S3JhbnosIFRob3JzdGVuIE0u|http://orcid.org/0000-0002-4894-2756|http://orcid.org/0000-0002-9064-2108|http://orcid.org/0000-0002-0870-8770|https://frl.publisso.de/adhoc/uri/V2VpY2hlcnQsIERhbnV0YQ==|https://frl.publisso.de/adhoc/uri/THV0eiwgQmVhdA==|https://frl.publisso.de/adhoc/uri/QmFzdGVuLCBVbHJpa2U=|http://orcid.org/0000-0003-0827-1721|https://frl.publisso.de/adhoc/uri/V2Vzc2EsIE1pY2hlbGU=|http://orcid.org/0000-0002-9503-7601|https://frl.publisso.de/adhoc/uri/TGllYiwgS2xhdXM=|https://frl.publisso.de/adhoc/uri/Q2hpb2NjaGV0dGksIEFuZHJlYXMgRy4=|http://orcid.org/0000-0002-4023-5301|http://orcid.org/0000-0002-0992-634X|https://frl.publisso.de/adhoc/uri/UGxpY2h0YSwgTWljaGFlbCBNLg==|
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1000 Erstellt am 2023-02-27T08:06:19.273+0100
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