Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium

  1. Pastorino, Roberta
  2. Sassano, Michele ORCID logo
  3. tiziano, francesco danilo ORCID logo
  4. Giraldi, Luca ORCID logo
  5. Amore, Rosarita ORCID logo
  6. Arzani, Dario ORCID logo
  7. Abiusi, Emanuela ORCID logo
  8. Ahrens, Wolfgang ORCID logo
  9. Alemany, Laia ORCID logo
  10. Canova, Cristina
  11. Healy, Claire M ORCID logo
  12. Holcatova, Ivana ORCID logo
  13. Lagiou, Pagona
  14. Polesel, Jerry ORCID logo
  15. Popovic, Maja ORCID logo
  16. Nygård, Ståle ORCID logo
  17. cadoni, gabriella ORCID logo
  18. Znaor, Ariana ORCID logo
  19. Boffetta, Paolo ORCID logo
  20. Matsuo, Keitaro ORCID logo
  21. Oze, Isao ORCID logo
  22. Brennan, Paul ORCID logo
  23. Boccia, Stefania ORCID logo

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Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer A Cross-sectional Study within the INHANCE Consortium.pdf 307,92KB
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1000 Titel
  • Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
1000 Autor/in
  1. Pastorino, Roberta |
  2. Sassano, Michele |
  3. tiziano, francesco danilo |
  4. Giraldi, Luca |
  5. Amore, Rosarita |
  6. Arzani, Dario |
  7. Abiusi, Emanuela |
  8. Ahrens, Wolfgang |
  9. Alemany, Laia |
  10. Canova, Cristina |
  11. Healy, Claire M |
  12. Holcatova, Ivana |
  13. Lagiou, Pagona |
  14. Polesel, Jerry |
  15. Popovic, Maja |
  16. Nygård, Ståle |
  17. cadoni, gabriella |
  18. Znaor, Ariana |
  19. Boffetta, Paolo |
  20. Matsuo, Keitaro |
  21. Oze, Isao |
  22. Brennan, Paul |
  23. Boccia, Stefania |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-12-05
1000 Erschienen in
1000 Quellenangabe
  • 31(12):2237-2243
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1158/1055-9965.EPI-22-0376 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720423/ |
1000 Ergänzendes Material
  • https://aacrjournals.org/cebp/article/31/12/2237/711112/Plasma-miR-151-3p-as-a-Candidate-Diagnostic#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Identification of screening tests for the detection of head and neck cancer (HNC) at an early stage is an important strategy to improving prognosis. Our objective was to identify plasma circulating miRNAs for the diagnosis of HNC (oral and laryngeal subsites), within a multicenter International Head and Neck Cancer Epidemiology consortium. METHODS: A high-throughput screening phase with 754 miRNAs was performed in plasma samples of 88 cases and 88 controls, followed by a validation phase of the differentially expressed miRNAs, identified in the screening, in samples of 396 cases and 396 controls. Comparison of the fold changes (FC) was carried out using the Wilcoxon rank-sum test and the Dunn multiple comparison test. RESULTS: We identified miR-151-3p (FC = 1.73, P = 0.007) as differentially expressed miRNAs in the screening and validation phase. The miR-151-3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls. CONCLUSIONS: We identified miR-151-3p as an early marker of HNC. This miRNA was the only upregulated in patients at early stages of the disease, independently of the smoking status. IMPACT: The prognosis for HNC is still poor. The discovery of a new diagnostic biomarker could lead to an earlier tumor discovery and therefore to an improvement in patient prognosis.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGFzdG9yaW5vLCBSb2JlcnRh|https://orcid.org/0000-0002-3158-1827|https://orcid.org/0000-0002-5545-6158|https://orcid.org/0000-0003-4775-2042|https://orcid.org/0000-0003-4070-1496|https://orcid.org/0000-0001-6525-8078|https://orcid.org/0000-0001-9028-012X|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0003-0945-6015|https://frl.publisso.de/adhoc/uri/Q2Fub3ZhLCBDcmlzdGluYQ==|https://orcid.org/0000-0003-0583-6360|https://orcid.org/0000-0002-1366-0337|https://frl.publisso.de/adhoc/uri/TGFnaW91LCBQYWdvbmE=|https://orcid.org/0000-0001-9381-1520|https://orcid.org/0000-0003-4500-6572|https://orcid.org/0000-0002-5263-4748|https://orcid.org/0000-0002-6239-838X|https://orcid.org/0000-0002-5849-4782|https://orcid.org/0000-0002-3811-2791|https://orcid.org/0000-0003-1761-6314|https://orcid.org/0000-0002-0762-1147|https://orcid.org/0000-0002-0518-8714|https://orcid.org/0000-0002-1864-749X
1000 Label
1000 Förderer
  1. Fondazione AIRC per la ricerca sul cancro ETS |
  2. Fondazione Umberto Veronesi |
  3. Università Cattolica del Sacro Cuore |
1000 Fördernummer
  1. 14220; J54G13000430007
  2. J54G13000430007
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
  1. Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
    Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Fondazione AIRC per la ricerca sul cancro ETS |
    1000 Förderprogramm -
    1000 Fördernummer 14220; J54G13000430007
  2. 1000 joinedFunding-child
    1000 Förderer Fondazione Umberto Veronesi |
    1000 Förderprogramm -
    1000 Fördernummer J54G13000430007
  3. 1000 joinedFunding-child
    1000 Förderer Università Cattolica del Sacro Cuore |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6440513.rdf
1000 Erstellt am 2023-03-03T12:25:51.131+0100
1000 Erstellt von 266
1000 beschreibt frl:6440513
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Fri Apr 21 13:42:26 CEST 2023
1000 Objekt bearb. Tue Mar 14 13:34:56 CET 2023
1000 Vgl. frl:6440513
1000 Oai Id
  1. oai:frl.publisso.de:frl:6440513 |
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