Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families

  1. Guzman-Parra, Jose
  2. Streit, Fabian ORCID logo
  3. Forstner, Andreas J ORCID logo
  4. Strohmaier, Jana ORCID logo
  5. González, Maria José
  6. Gil Flores, Susana
  7. Cabaleiro Fabeiro, Francisco J.
  8. del Río Noriega, Francisco
  9. Perez Perez, Fermin
  10. Haro González, Jesus
  11. Orozco Diaz, Guillermo
  12. de Diego-Otero, yolanda ORCID logo
  13. Moreno-Kustner, Berta
  14. Auburger, Georg
  15. Degenhardt, Franziska
  16. Heilmann-Heimbach, Stefanie
  17. Herms, Stefan ORCID logo
  18. Hoffmann, Per
  19. Frank, Josef ORCID logo
  20. Foo, Jerome Clifford ORCID logo
  21. Sirignano, Lea ORCID logo
  22. Witt, Stephanie ORCID logo
  23. Cichon, Sven
  24. Rivas, Fabio
  25. Mayoral, Fermín
  26. Nöthen, Markus M.
  27. Andlauer, Till ORCID logo
  28. Rietschel, Marcella ORCID logo

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1000 Titel
  • Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families
1000 Autor/in
  1. Guzman-Parra, Jose |
  2. Streit, Fabian |
  3. Forstner, Andreas J |
  4. Strohmaier, Jana |
  5. González, Maria José |
  6. Gil Flores, Susana |
  7. Cabaleiro Fabeiro, Francisco J. |
  8. del Río Noriega, Francisco |
  9. Perez Perez, Fermin |
  10. Haro González, Jesus |
  11. Orozco Diaz, Guillermo |
  12. de Diego-Otero, yolanda |
  13. Moreno-Kustner, Berta |
  14. Auburger, Georg |
  15. Degenhardt, Franziska |
  16. Heilmann-Heimbach, Stefanie |
  17. Herms, Stefan |
  18. Hoffmann, Per |
  19. Frank, Josef |
  20. Foo, Jerome Clifford |
  21. Sirignano, Lea |
  22. Witt, Stephanie |
  23. Cichon, Sven |
  24. Rivas, Fabio |
  25. Mayoral, Fermín |
  26. Nöthen, Markus M. |
  27. Andlauer, Till |
  28. Rietschel, Marcella |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-11
1000 Erschienen in
1000 Quellenangabe
  • 11(1):31
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-020-01146-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801527/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less severe form of BD-I. Recent research has challenged this concept of a severity continuum. Studies in large samples of unrelated patients have described clinical and genetic differences between the subtypes. Besides an increased schizophrenia polygenic risk load in BD-I, these studies also observed an increased depression risk load in BD-II patients. The present study assessed whether such clinical and genetic differences are also found in BD patients from multiplex families, which exhibit reduced genetic and environmental heterogeneity. Comparing 252 BD-I and 75 BD-II patients from the Andalusian Bipolar Family (ABiF) study, the clinical course, symptoms during depressive and manic episodes, and psychiatric comorbidities were analyzed. Furthermore, polygenic risk scores (PRS) for BD, schizophrenia, and depression were assessed. BD-I patients not only suffered from more severe symptoms during manic episodes but also more frequently showed incapacity during depressive episodes. A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line with a severity continuum from BD-II to BD-I, our results link BD-I to a more pronounced clinical presentation in both mania and depression and indicate that the polygenic risk load of BD predisposes to more severe disorder characteristics. Nevertheless, our results suggest that the genetic risk burden for depression also shapes disorder presentation and increases the likelihood of BD-II subtype development.
1000 Sacherschließung
lokal Schizophrenia/genetics [MeSH]
lokal Article
lokal Suicidal Ideation [MeSH]
lokal Humans [MeSH]
lokal Bipolar disorder
lokal Risk Factors [MeSH]
lokal Multifactorial Inheritance [MeSH]
lokal Bipolar Disorder/genetics [MeSH]
lokal Clinical genetics
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R3V6bWFuLVBhcnJhLCBKb3Nl|https://orcid.org/0000-0003-1080-4339|https://orcid.org/0000-0002-1876-6368|https://orcid.org/0000-0002-4364-1487|https://frl.publisso.de/adhoc/uri/R29uesOhbGV6LCBNYXJpYSBKb3PDqQ==|https://frl.publisso.de/adhoc/uri/R2lsIEZsb3JlcywgU3VzYW5h|https://frl.publisso.de/adhoc/uri/Q2FiYWxlaXJvIEZhYmVpcm8sIEZyYW5jaXNjbyBKLg==|https://frl.publisso.de/adhoc/uri/ZGVsIFLDrW8gTm9yaWVnYSwgRnJhbmNpc2Nv|https://frl.publisso.de/adhoc/uri/UGVyZXogUGVyZXosIEZlcm1pbg==|https://frl.publisso.de/adhoc/uri/SGFybyBHb256w6FsZXosIEplc3Vz|https://frl.publisso.de/adhoc/uri/T3JvemNvIERpYXosIEd1aWxsZXJtbw==|https://orcid.org/0000-0003-2384-8349|https://frl.publisso.de/adhoc/uri/TW9yZW5vLUt1c3RuZXIsIEJlcnRh|https://frl.publisso.de/adhoc/uri/QXVidXJnZXIsIEdlb3Jn|https://frl.publisso.de/adhoc/uri/RGVnZW5oYXJkdCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/uri/SGVpbG1hbm4tSGVpbWJhY2gsIFN0ZWZhbmll|https://orcid.org/0000-0002-2786-8200|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFBlcg==|https://orcid.org/0000-0003-4867-9465|https://orcid.org/0000-0003-1067-5725|https://orcid.org/0000-0002-7989-5833|https://orcid.org/0000-0002-1571-1468|https://frl.publisso.de/adhoc/uri/Q2ljaG9uLCBTdmVu|https://frl.publisso.de/adhoc/uri/Uml2YXMsIEZhYmlv|https://frl.publisso.de/adhoc/uri/TWF5b3JhbCwgRmVybcOtbg==|https://frl.publisso.de/adhoc/uri/TsO2dGhlbiwgTWFya3VzIE0u|https://orcid.org/0000-0002-2917-5889|https://orcid.org/0000-0002-5236-6149
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1000 Erstellt am 2023-04-26T14:53:34.767+0200
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1000 Zuletzt bearbeitet 2023-10-19T12:56:48.707+0200
1000 Objekt bearb. Thu Oct 19 12:56:48 CEST 2023
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