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1000 Titel
  • High-throughput base editing: a promising technology for precision medicine and drug discovery
1000 Autor/in
  1. Sachinidis, Agapios |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-04
1000 Erschienen in
1000 Quellenangabe
  • 6(1):221
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41392-021-00633-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179922/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Sewage sludge is formed during wastewater treatment and in recent years, the amount of sewage sludge increased rapidly all over the world. This sewage sludge is attractive for usage in agriculture as an inexpensive nitrogen and phosphorus fertilizer. However, there is only very limited knowledge about the spectrum of organic pollutants that might occur in sewage sludge and is probably posing a threat to the environment. We therefore conducted GC–MS based non-target screening analyses in order to identify a wide spectrum of organic contaminants in sludge samples from several wastewater treatment plants and to figure out corresponding finger-prints of pollution. The plants are located in Germany and China and have various capacities ranging from 35,000 to 1.1 million population equivalents. The special focus was to reveal information on the structural variety of individual organic compounds in sludge samples from the two countries. Several emerging pollutants including some fragrances, pharmaceutical educts, vitaminoids, technical additives were identified accompanied by compounds of biogenic origin. Some of these compounds have rarely been reported as constituents of sewage sludge to date and, consequently, are relevant candidates for more specific assessments including the ecotoxicological long-term effects. Based on the results of this study, it seems mandatory to establish non-target screening analyses on a regularly base as a tool for a comprehensive identification of the variety of anthropogenic organic constituents. Following, such contaminant spectrum can act as basis for further environmental risk assessments as well as to provide individual fingerprints for evaluation of impacts on ecosystems.</jats:p>
1000 Sacherschließung
lokal Genomics
lokal Gene Editing [MeSH]
lokal Research Highlight
lokal Drug Discovery [MeSH]
lokal CRISPR-Cas Systems [MeSH]
lokal Technology [MeSH]
lokal Molecular medicine
lokal Precision Medicine [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2FjaGluaWRpcywgQWdhcGlvcw==
1000 Hinweis
  • DeepGreen-ID: e738ffa9e2a0442da8d385af558ba7ca ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-04-26T15:07:45.870+0200
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1000 Zuletzt bearbeitet Sat Oct 14 03:49:08 CEST 2023
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1000 Vgl. frl:6442626
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  1. oai:frl.publisso.de:frl:6442626 |
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