Mendelian randomisation study of smoking exposure in relation to breast cancer risk

  1. Park, Hanla ORCID logo
  2. Neumeyer, Sonja
  3. Michailidou, Kyriaki
  4. Bolla, Manjeet K.
  5. Wang, Qin
  6. Dennis, Joe ORCID logo
  7. Ahearn, Thomas U.
  8. Andrulis, Irene L.
  9. Anton-Culver, Hoda
  10. Antonenkova, Natalia N.
  11. Arndt, Volker
  12. Aronson, Kristan J.
  13. Augustinsson, Annelie ORCID logo
  14. Baten, Adinda
  15. Beane Freeman, Laura E.
  16. Becher, Heiko
  17. Beckmann, Matthias W.
  18. Behrens, Sabine
  19. Benitez, Javier
  20. Bermisheva, Marina
  21. Bogdanova, Natalia V.
  22. Bojesen, Stig E.
  23. Brauch, Hiltrud
  24. Brenner, Hermann ORCID logo
  25. Brucker, Sara Y.
  26. Burwinkel, Barbara
  27. Campa, Daniele
  28. Canzian, Federico ORCID logo
  29. Castelao, Jose E.
  30. Chanock, Stephen J.
  31. Clarke, Christine L.
  32. Børresen-Dale, Anne-Lise
  33. Grenaker Alnæs, Grethe I.
  34. Sahlberg, Kristine K.
  35. Ottestad, Lars
  36. Kåresen, Rolf
  37. Schlichting, Ellen
  38. Holmen, Marit Muri
  39. Sauer, Toril
  40. Haakensen, Vilde
  41. Engebråten, Olav
  42. Naume, Bjørn
  43. Fosså, Alexander
  44. Kiserud, Cecile E.
  45. Reinertsen, Kristin V.
  46. Helland, Åslaug
  47. Riis, Margit
  48. Geisler, Jürgen
  49. Conroy, Don M.
  50. Couch, Fergus J.
  51. Cox, Angela ORCID logo
  52. Cross, Simon S.
  53. Czene, Kamila
  54. Daly, Mary B.
  55. Devilee, Peter ORCID logo
  56. Dörk, Thilo
  57. dos-Santos-Silva, Isabel
  58. Dwek, Miriam
  59. Eccles, Diana M.
  60. Eliassen, A. Heather
  61. Engel, Christoph
  62. Eriksson, Mikael
  63. Evans, D. Gareth
  64. Fasching, Peter A. ORCID logo
  65. Flyger, Henrik
  66. Fritschi, Lin
  67. García-Closas, Montserrat
  68. García-Sáenz, José A.
  69. Gaudet, Mia M.
  70. Giles, Graham G.
  71. Glendon, Gord
  72. Goldberg, Mark S.
  73. Goldgar, David E.
  74. González-Neira, Anna
  75. Grip, Mervi
  76. Guénel, Pascal
  77. Hahnen, Eric
  78. Haiman, Christopher A.
  79. Håkansson, Niclas
  80. Hall, Per
  81. Hamann, Ute
  82. Han, Sileny
  83. Harkness, Elaine ORCID logo
  84. Hart, Steven ORCID logo
  85. He, Wei
  86. Heemskerk-Gerritsen, Bernadette ORCID logo
  87. Hopper, John L.
  88. Hunter, David J.
  89. Clarke, Christine
  90. Baxter, Robert
  91. Yip, Desmond
  92. Carpenter, Jane
  93. Davis, Alison
  94. Pathmanathan, Nirmala
  95. Graham, Dinny
  96. Sachchithananthan, Mythily
  97. Amor, David
  98. Andrews, Lesley
  99. Antill, Yoland
  100. Balleine, Rosemary
  101. Beesley, Jonathan
  102. Bennett, Ian
  103. Bogwitz, Michael
  104. Botes, Leon
  105. Brennan, Meagan
  106. Brown, Melissa
  107. Buckley, Michael
  108. Burke, Jo
  109. Butow, Phyllis
  110. Caldon, Liz
  111. Campbell, Ian
  112. Chauhan, Deepa
  113. Chauhan, Manisha
  114. Chenevix-Trench, Georgia
  115. Christian, Alice
  116. Cohen, Paul
  117. Colley, Alison
  118. Crook, Ashley
  119. Cui, James
  120. Cummings, Margaret
  121. Dawson, Sarah-Jane
  122. DeFazio, Anna
  123. Delatycki, Martin
  124. Dickson, Rebecca
  125. Dixon, Joanne
  126. Edkins, Ted
  127. Edwards, Stacey
  128. Farshid, Gelareh
  129. Fellows, Andrew
  130. Fenton, Georgina
  131. Field, Michael
  132. Flanagan, James
  133. Fong, Peter
  134. Forrest, Laura
  135. Fox, Stephen
  136. French, Juliet
  137. Friedlander, Michael
  138. Gaff, Clara
  139. Gattas, Mike
  140. George, Peter
  141. Greening, Sian
  142. Harris, Marion
  143. Hart, Stewart
  144. Hayward, Nick
  145. Hopper, John
  146. Hoskins, Cass
  147. Hunt, Clare
  148. James, Paul
  149. Jenkins, Mark
  150. Kidd, Alexa
  151. Kirk, Judy
  152. Koehler, Jessica
  153. Kollias, James
  154. Lakhani, Sunil
  155. Lawrence, Mitchell
  156. Lindeman, Geoff
  157. Lipton, Lara
  158. Lobb, Liz
  159. Mann, Graham
  160. Marsh, Deborah
  161. McLachlan, Sue Anne
  162. Meiser, Bettina
  163. Milne, Roger
  164. Nightingale, Sophie
  165. O’Connell, Shona
  166. O’Sullivan, Sarah
  167. Ortega, David Gallego
  168. Pachter, Nick
  169. Patterson, Briony
  170. Pearn, Amy
  171. Phillips, Kelly
  172. Pieper, Ellen
  173. Rickard, Edwina
  174. Robinson, Bridget
  175. Saleh, Mona
  176. Salisbury, Elizabeth
  177. Saunders, Christobel
  178. Saunus, Jodi
  179. Scott, Rodney
  180. Scott, Clare
  181. Sexton, Adrienne
  182. Shelling, Andrew
  183. Simpson, Peter
  184. Southey, Melissa
  185. Spurdle, Amanda
  186. Taylor, Jessica
  187. Taylor, Renea
  188. Thorne, Heather
  189. Trainer, Alison
  190. Tucker, Kathy
  191. Visvader, Jane
  192. Walker, Logan
  193. Williams, Rachael
  194. Winship, Ingrid
  195. Young, Mary Ann
  196. Jager, Agnes
  197. Jakubowska, Anna ORCID logo
  198. John, Esther M.
  199. Jung, Audrey
  200. Kaaks, Rudolf
  201. Middha, Pooja ORCID logo
  202. Keeman, Renske
  203. Khusnutdinova, Elza
  204. Kitahara, Cari M.
  205. Koppert, Linetta B.
  206. Koutros, Stella
  207. Kristensen, Vessela N.
  208. Kurian, Allison ORCID logo
  209. Lacey, James
  210. Lambrechts, Diether
  211. Le Marchand, Loic
  212. Lo, Wing-Yee
  213. Lubiński, Jan
  214. Mannermaa, Arto
  215. Manoochehri, Mehdi
  216. Margolin, Sara
  217. Martinez, Maria Elena
  218. Mavroudis, Dimitrios
  219. Meindl, Alfons
  220. Menon, Usha
  221. Milne, Roger L.
  222. Muranen, Taru A.
  223. Nevanlinna, Heli
  224. Newman, William ORCID logo
  225. Nordestgaard, Børge G.
  226. Offit, Kenneth
  227. Olshan, Andrew F.
  228. Olsson, Håkan
  229. Park-Simon, Tjoung-Won
  230. Peterlongo, Paolo ORCID logo
  231. peto, julian ORCID logo
  232. Plaseska-Karanfilska, Dijana
  233. Presneau, Nadege
  234. Radice, Paolo
  235. Rennert, Gad
  236. Rennert, Hedy S.
  237. Romero, Atocha
  238. Saloustros, Emmanouil
  239. Sawyer, Elinor ORCID logo
  240. Schmidt, Marjanka K.
  241. Schmutzler, Rita K.
  242. Schoemaker, Minouk J.
  243. Schwentner, Lukas
  244. Scott, Christopher ORCID logo
  245. Shah, Mitul
  246. Shu, Xiao-Ou
  247. Simard, Jacques
  248. Smeets, Ann ORCID logo
  249. Southey, Melissa C.
  250. Spinelli, John J.
  251. Stevens, Victoria
  252. Swerdlow, Anthony J.
  253. Tamimi, Rulla M.
  254. Tapper, William J.
  255. Taylor, Jack A.
  256. Terry, Mary Beth
  257. Tomlinson, Ian ORCID logo
  258. Troester, Melissa A.
  259. Truong, Therese ORCID logo
  260. Vachon, Celine M.
  261. van Veen, Elke M.
  262. Vijai, Joseph
  263. Wang, Sophia
  264. Wendt, Camilla
  265. Winqvist, Robert
  266. Wolk, Alicja
  267. Ziogas, Argyrios
  268. Dunning, Alison M.
  269. Pharoah, Paul ORCID logo
  270. Easton, Douglas F.
  271. Zheng, Wei
  272. Kraft, Peter
  273. Chang-Claude, Jenny

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1000 Titel
  • Mendelian randomisation study of smoking exposure in relation to breast cancer risk
1000 Autor/in
  1. Park, Hanla |
  2. Neumeyer, Sonja |
  3. Michailidou, Kyriaki |
  4. Bolla, Manjeet K. |
  5. Wang, Qin |
  6. Dennis, Joe |
  7. Ahearn, Thomas U. |
  8. Andrulis, Irene L. |
  9. Anton-Culver, Hoda |
  10. Antonenkova, Natalia N. |
  11. Arndt, Volker |
  12. Aronson, Kristan J. |
  13. Augustinsson, Annelie |
  14. Baten, Adinda |
  15. Beane Freeman, Laura E. |
  16. Becher, Heiko |
  17. Beckmann, Matthias W. |
  18. Behrens, Sabine |
  19. Benitez, Javier |
  20. Bermisheva, Marina |
  21. Bogdanova, Natalia V. |
  22. Bojesen, Stig E. |
  23. Brauch, Hiltrud |
  24. Brenner, Hermann |
  25. Brucker, Sara Y. |
  26. Burwinkel, Barbara |
  27. Campa, Daniele |
  28. Canzian, Federico |
  29. Castelao, Jose E. |
  30. Chanock, Stephen J. |
  31. Clarke, Christine L. |
  32. Børresen-Dale, Anne-Lise |
  33. Grenaker Alnæs, Grethe I. |
  34. Sahlberg, Kristine K. |
  35. Ottestad, Lars |
  36. Kåresen, Rolf |
  37. Schlichting, Ellen |
  38. Holmen, Marit Muri |
  39. Sauer, Toril |
  40. Haakensen, Vilde |
  41. Engebråten, Olav |
  42. Naume, Bjørn |
  43. Fosså, Alexander |
  44. Kiserud, Cecile E. |
  45. Reinertsen, Kristin V. |
  46. Helland, Åslaug |
  47. Riis, Margit |
  48. Geisler, Jürgen |
  49. Conroy, Don M. |
  50. Couch, Fergus J. |
  51. Cox, Angela |
  52. Cross, Simon S. |
  53. Czene, Kamila |
  54. Daly, Mary B. |
  55. Devilee, Peter |
  56. Dörk, Thilo |
  57. dos-Santos-Silva, Isabel |
  58. Dwek, Miriam |
  59. Eccles, Diana M. |
  60. Eliassen, A. Heather |
  61. Engel, Christoph |
  62. Eriksson, Mikael |
  63. Evans, D. Gareth |
  64. Fasching, Peter A. |
  65. Flyger, Henrik |
  66. Fritschi, Lin |
  67. García-Closas, Montserrat |
  68. García-Sáenz, José A. |
  69. Gaudet, Mia M. |
  70. Giles, Graham G. |
  71. Glendon, Gord |
  72. Goldberg, Mark S. |
  73. Goldgar, David E. |
  74. González-Neira, Anna |
  75. Grip, Mervi |
  76. Guénel, Pascal |
  77. Hahnen, Eric |
  78. Haiman, Christopher A. |
  79. Håkansson, Niclas |
  80. Hall, Per |
  81. Hamann, Ute |
  82. Han, Sileny |
  83. Harkness, Elaine |
  84. Hart, Steven |
  85. He, Wei |
  86. Heemskerk-Gerritsen, Bernadette |
  87. Hopper, John L. |
  88. Hunter, David J. |
  89. Clarke, Christine |
  90. Baxter, Robert |
  91. Yip, Desmond |
  92. Carpenter, Jane |
  93. Davis, Alison |
  94. Pathmanathan, Nirmala |
  95. Graham, Dinny |
  96. Sachchithananthan, Mythily |
  97. Amor, David |
  98. Andrews, Lesley |
  99. Antill, Yoland |
  100. Balleine, Rosemary |
  101. Beesley, Jonathan |
  102. Bennett, Ian |
  103. Bogwitz, Michael |
  104. Botes, Leon |
  105. Brennan, Meagan |
  106. Brown, Melissa |
  107. Buckley, Michael |
  108. Burke, Jo |
  109. Butow, Phyllis |
  110. Caldon, Liz |
  111. Campbell, Ian |
  112. Chauhan, Deepa |
  113. Chauhan, Manisha |
  114. Chenevix-Trench, Georgia |
  115. Christian, Alice |
  116. Cohen, Paul |
  117. Colley, Alison |
  118. Crook, Ashley |
  119. Cui, James |
  120. Cummings, Margaret |
  121. Dawson, Sarah-Jane |
  122. DeFazio, Anna |
  123. Delatycki, Martin |
  124. Dickson, Rebecca |
  125. Dixon, Joanne |
  126. Edkins, Ted |
  127. Edwards, Stacey |
  128. Farshid, Gelareh |
  129. Fellows, Andrew |
  130. Fenton, Georgina |
  131. Field, Michael |
  132. Flanagan, James |
  133. Fong, Peter |
  134. Forrest, Laura |
  135. Fox, Stephen |
  136. French, Juliet |
  137. Friedlander, Michael |
  138. Gaff, Clara |
  139. Gattas, Mike |
  140. George, Peter |
  141. Greening, Sian |
  142. Harris, Marion |
  143. Hart, Stewart |
  144. Hayward, Nick |
  145. Hopper, John |
  146. Hoskins, Cass |
  147. Hunt, Clare |
  148. James, Paul |
  149. Jenkins, Mark |
  150. Kidd, Alexa |
  151. Kirk, Judy |
  152. Koehler, Jessica |
  153. Kollias, James |
  154. Lakhani, Sunil |
  155. Lawrence, Mitchell |
  156. Lindeman, Geoff |
  157. Lipton, Lara |
  158. Lobb, Liz |
  159. Mann, Graham |
  160. Marsh, Deborah |
  161. McLachlan, Sue Anne |
  162. Meiser, Bettina |
  163. Milne, Roger |
  164. Nightingale, Sophie |
  165. O’Connell, Shona |
  166. O’Sullivan, Sarah |
  167. Ortega, David Gallego |
  168. Pachter, Nick |
  169. Patterson, Briony |
  170. Pearn, Amy |
  171. Phillips, Kelly |
  172. Pieper, Ellen |
  173. Rickard, Edwina |
  174. Robinson, Bridget |
  175. Saleh, Mona |
  176. Salisbury, Elizabeth |
  177. Saunders, Christobel |
  178. Saunus, Jodi |
  179. Scott, Rodney |
  180. Scott, Clare |
  181. Sexton, Adrienne |
  182. Shelling, Andrew |
  183. Simpson, Peter |
  184. Southey, Melissa |
  185. Spurdle, Amanda |
  186. Taylor, Jessica |
  187. Taylor, Renea |
  188. Thorne, Heather |
  189. Trainer, Alison |
  190. Tucker, Kathy |
  191. Visvader, Jane |
  192. Walker, Logan |
  193. Williams, Rachael |
  194. Winship, Ingrid |
  195. Young, Mary Ann |
  196. Jager, Agnes |
  197. Jakubowska, Anna |
  198. John, Esther M. |
  199. Jung, Audrey |
  200. Kaaks, Rudolf |
  201. Middha, Pooja |
  202. Keeman, Renske |
  203. Khusnutdinova, Elza |
  204. Kitahara, Cari M. |
  205. Koppert, Linetta B. |
  206. Koutros, Stella |
  207. Kristensen, Vessela N. |
  208. Kurian, Allison |
  209. Lacey, James |
  210. Lambrechts, Diether |
  211. Le Marchand, Loic |
  212. Lo, Wing-Yee |
  213. Lubiński, Jan |
  214. Mannermaa, Arto |
  215. Manoochehri, Mehdi |
  216. Margolin, Sara |
  217. Martinez, Maria Elena |
  218. Mavroudis, Dimitrios |
  219. Meindl, Alfons |
  220. Menon, Usha |
  221. Milne, Roger L. |
  222. Muranen, Taru A. |
  223. Nevanlinna, Heli |
  224. Newman, William |
  225. Nordestgaard, Børge G. |
  226. Offit, Kenneth |
  227. Olshan, Andrew F. |
  228. Olsson, Håkan |
  229. Park-Simon, Tjoung-Won |
  230. Peterlongo, Paolo |
  231. peto, julian |
  232. Plaseska-Karanfilska, Dijana |
  233. Presneau, Nadege |
  234. Radice, Paolo |
  235. Rennert, Gad |
  236. Rennert, Hedy S. |
  237. Romero, Atocha |
  238. Saloustros, Emmanouil |
  239. Sawyer, Elinor |
  240. Schmidt, Marjanka K. |
  241. Schmutzler, Rita K. |
  242. Schoemaker, Minouk J. |
  243. Schwentner, Lukas |
  244. Scott, Christopher |
  245. Shah, Mitul |
  246. Shu, Xiao-Ou |
  247. Simard, Jacques |
  248. Smeets, Ann |
  249. Southey, Melissa C. |
  250. Spinelli, John J. |
  251. Stevens, Victoria |
  252. Swerdlow, Anthony J. |
  253. Tamimi, Rulla M. |
  254. Tapper, William J. |
  255. Taylor, Jack A. |
  256. Terry, Mary Beth |
  257. Tomlinson, Ian |
  258. Troester, Melissa A. |
  259. Truong, Therese |
  260. Vachon, Celine M. |
  261. van Veen, Elke M. |
  262. Vijai, Joseph |
  263. Wang, Sophia |
  264. Wendt, Camilla |
  265. Winqvist, Robert |
  266. Wolk, Alicja |
  267. Ziogas, Argyrios |
  268. Dunning, Alison M. |
  269. Pharoah, Paul |
  270. Easton, Douglas F. |
  271. Zheng, Wei |
  272. Kraft, Peter |
  273. Chang-Claude, Jenny |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-02
1000 Erschienen in
1000 Quellenangabe
  • 125(8):1135-1145
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41416-021-01432-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505411/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk.!##!Methods!#!We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.!##!Results!#!Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10!##!Conclusion!#!Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
1000 Sacherschließung
lokal Breast Neoplasms/etiology [MeSH]
lokal Genetic Predisposition to Disease [MeSH]
lokal Female [MeSH]
lokal Cigarette Smoking/epidemiology [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Humans [MeSH]
lokal Breast Neoplasms/genetics [MeSH]
lokal Breast cancer
lokal Cigarette Smoking/genetics [MeSH]
lokal Breast Neoplasms/epidemiology [MeSH]
lokal Risk factors
lokal Genome-Wide Association Study [MeSH]
lokal Article
lokal Cigarette Smoking/adverse effects [MeSH]
lokal Genetic Pleiotropy [MeSH]
lokal Case-Control Studies [MeSH]
lokal Mendelian Randomization Analysis [MeSH]
lokal Genotyping Techniques [MeSH]
1000 Liste der Beteiligten
  1. 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1000 Hinweis
  • DeepGreen-ID: 7c9b82d926fc459db4f3380a44ae1dbe ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
1000 Objektart article
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1000 @id frl:6442884.rdf
1000 Erstellt am 2023-04-26T16:05:52.686+0200
1000 Erstellt von 322
1000 beschreibt frl:6442884
1000 Zuletzt bearbeitet 2023-10-19T13:35:03.099+0200
1000 Objekt bearb. Thu Oct 19 13:35:03 CEST 2023
1000 Vgl. frl:6442884
1000 Oai Id
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