Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort

  1. Weber, Heike ORCID logo
  2. Maihofer, Adam X.
  3. Jaksic, Nenad
  4. Bojic, Elma Feric
  5. Kucukalic, Sabina
  6. Dzananovic, Emina Sabic
  7. Uka, Aferdita Goci
  8. Hoxha, Blerina
  9. Haxhibeqiri, Valdete
  10. Haxhibeqiri, Shpend
  11. Kravic, Nermina
  12. Umihanic, Mirnesa Muminovic
  13. Franc, Ana Cima
  14. Babic, Romana
  15. Pavlovic, Marko
  16. Mehmedbasic, Alma Bravo
  17. Aukst-Margetic, Branka
  18. Kucukalic, Abdulah
  19. Marjanovic, Damir
  20. Babic, Dragan
  21. Bozina, Nada
  22. Jakovljevic, Miro
  23. Sinanovic, Osman
  24. Avdibegović, Esmina
  25. Agani, Ferid
  26. Warrings, Bodo
  27. Domschke, Katharina
  28. Nievergelt, Caroline M.
  29. Deckert, Jürgen
  30. Dzubur-Kulenovic, Alma
  31. Erhardt, Angelika

Download
s00702-021-02446-5.pdf 1,05MB
WeightNameValue
1000 Titel
  • Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort
1000 Autor/in
  1. Weber, Heike |
  2. Maihofer, Adam X. |
  3. Jaksic, Nenad |
  4. Bojic, Elma Feric |
  5. Kucukalic, Sabina |
  6. Dzananovic, Emina Sabic |
  7. Uka, Aferdita Goci |
  8. Hoxha, Blerina |
  9. Haxhibeqiri, Valdete |
  10. Haxhibeqiri, Shpend |
  11. Kravic, Nermina |
  12. Umihanic, Mirnesa Muminovic |
  13. Franc, Ana Cima |
  14. Babic, Romana |
  15. Pavlovic, Marko |
  16. Mehmedbasic, Alma Bravo |
  17. Aukst-Margetic, Branka |
  18. Kucukalic, Abdulah |
  19. Marjanovic, Damir |
  20. Babic, Dragan |
  21. Bozina, Nada |
  22. Jakovljevic, Miro |
  23. Sinanovic, Osman |
  24. Avdibegović, Esmina |
  25. Agani, Ferid |
  26. Warrings, Bodo |
  27. Domschke, Katharina |
  28. Nievergelt, Caroline M. |
  29. Deckert, Jürgen |
  30. Dzubur-Kulenovic, Alma |
  31. Erhardt, Angelika |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-27
1000 Erschienen in
1000 Quellenangabe
  • 129(5-6):661-674
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00702-021-02446-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188618/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Objectives: Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. Methods: Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. Results: The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. Conclusions: The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.
1000 Sacherschließung
lokal Stress Disorders, Post-Traumatic/genetics [MeSH]
lokal Humans [MeSH]
lokal Life events
lokal Stress Disorders, Post-Traumatic/psychology [MeSH]
lokal Stress Disorders, Post-Traumatic/diagnosis [MeSH]
lokal Coping style
lokal Polygenic risk score
lokal Risk Factors [MeSH]
lokal CAPS
lokal PTSD
lokal Psychiatry and Preclinical Psychiatric Studies - Original Article
lokal Adaptation, Psychological [MeSH]
lokal Europe, Eastern [MeSH]
lokal Emotions [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9421-1292|https://frl.publisso.de/adhoc/uri/TWFpaG9mZXIsIEFkYW0gWC4=|https://frl.publisso.de/adhoc/uri/SmFrc2ljLCBOZW5hZA==|https://frl.publisso.de/adhoc/uri/Qm9qaWMsIEVsbWEgRmVyaWM=|https://frl.publisso.de/adhoc/uri/S3VjdWthbGljLCBTYWJpbmE=|https://frl.publisso.de/adhoc/uri/RHphbmFub3ZpYywgRW1pbmEgU2FiaWM=|https://frl.publisso.de/adhoc/uri/VWthLCBBZmVyZGl0YSBHb2Np|https://frl.publisso.de/adhoc/uri/SG94aGEsIEJsZXJpbmE=|https://frl.publisso.de/adhoc/uri/SGF4aGliZXFpcmksIFZhbGRldGU=|https://frl.publisso.de/adhoc/uri/SGF4aGliZXFpcmksIFNocGVuZA==|https://frl.publisso.de/adhoc/uri/S3JhdmljLCBOZXJtaW5h|https://frl.publisso.de/adhoc/uri/VW1paGFuaWMsIE1pcm5lc2EgTXVtaW5vdmlj|https://frl.publisso.de/adhoc/uri/RnJhbmMsIEFuYSBDaW1h|https://frl.publisso.de/adhoc/uri/QmFiaWMsIFJvbWFuYQ==|https://frl.publisso.de/adhoc/uri/UGF2bG92aWMsIE1hcmtv|https://frl.publisso.de/adhoc/uri/TWVobWVkYmFzaWMsIEFsbWEgQnJhdm8=|https://frl.publisso.de/adhoc/uri/QXVrc3QtTWFyZ2V0aWMsIEJyYW5rYQ==|https://frl.publisso.de/adhoc/uri/S3VjdWthbGljLCBBYmR1bGFo|https://frl.publisso.de/adhoc/uri/TWFyamFub3ZpYywgRGFtaXI=|https://frl.publisso.de/adhoc/uri/QmFiaWMsIERyYWdhbg==|https://frl.publisso.de/adhoc/uri/Qm96aW5hLCBOYWRh|https://frl.publisso.de/adhoc/uri/SmFrb3ZsamV2aWMsIE1pcm8=|https://frl.publisso.de/adhoc/uri/U2luYW5vdmljLCBPc21hbg==|https://frl.publisso.de/adhoc/uri/QXZkaWJlZ292acSHLCBFc21pbmE=|https://frl.publisso.de/adhoc/uri/QWdhbmksIEZlcmlk|https://frl.publisso.de/adhoc/uri/V2FycmluZ3MsIEJvZG8=|https://frl.publisso.de/adhoc/uri/RG9tc2Noa2UsIEthdGhhcmluYQ==|https://frl.publisso.de/adhoc/uri/TmlldmVyZ2VsdCwgQ2Fyb2xpbmUgTS4=|https://frl.publisso.de/adhoc/uri/RGVja2VydCwgSsO8cmdlbg==|https://frl.publisso.de/adhoc/uri/RHp1YnVyLUt1bGVub3ZpYywgQWxtYQ==|https://frl.publisso.de/adhoc/uri/RXJoYXJkdCwgQW5nZWxpa2E=
1000 Hinweis
  • DeepGreen-ID: 90462cf44c22400e9fefd73140841951 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6446508.rdf
1000 Erstellt am 2023-04-28T13:21:58.563+0200
1000 Erstellt von 322
1000 beschreibt frl:6446508
1000 Zuletzt bearbeitet 2023-10-20T18:25:48.791+0200
1000 Objekt bearb. Fri Oct 20 18:25:48 CEST 2023
1000 Vgl. frl:6446508
1000 Oai Id
  1. oai:frl.publisso.de:frl:6446508 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source