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1000 Titel
  • Quality of life, distress, and posttraumatic growth 5 years after colorectal cancer diagnosis according to history of inpatient rehabilitation
1000 Autor/in
  1. Scherer-Trame, Sophie |
  2. Jansen, Lina |
  3. Koch-Gallenkamp, Lena |
  4. Arndt, Volker |
  5. Chang-Claude, Jenny |
  6. Hoffmeister, Michael |
  7. Brenner, Hermann |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-07
1000 Erschienen in
1000 Quellenangabe
  • 148(11):3015-3028
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00432-021-03865-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508041/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!In Germany, almost every other colorectal cancer (CRC) patient undergoes inpatient cancer rehabilitation (ICR), but research on long-term outcomes is sparse. We aimed to assess health-related quality of life (HRQOL), distress, and posttraumatic growth among former rehabilitants and non-rehabilitants as well as respective differences and to estimate disease-related quality of life deficits in both groups.!##!Methods!#!HRQOL (EORTC-QLQ-C30/CR29), distress (QSC-R10), and posttraumatic growth (PTGI) were assessed according to past ICR in patients 5-year post-CRC-diagnosis in the German DACHS study. Least square mean differences in HRQOL scores and elevated distress levels (QSC-R10 > 14 points) by ICR were estimated by confounder-adjusted linear and logistic regression, respectively. Differences in PTGI scales were tested for statistical significance. EORTC-QLQ-C30 reference scores from population controls were accessed from the LinDE study to estimate disease-related deficits in both treatment groups.!##!Results!#!49% of the included 1906 CRC survivors had undergone ICR. Rehabilitants reported lower HRQOL scores than non-rehabilitants in several dimensions of the EORTC-QLQ-C30/CR29. Differences were pronounced among younger survivors (< 70 years). In younger survivors, past ICR also predicted elevated distress. However, rehabilitants showed higher posttraumatic growth. When compared to 934 population controls, non-rehabilitants and older rehabilitants reported HRQOL scores (EORTC-QLQ-C30) similar to controls except higher levels of bowel dysfunctions, whereas younger rehabilitants experienced deficits regarding most scales (13/15).!##!Conclusion!#!Our findings suggest a high disease burden 5 years after diagnosis in particular among younger CRC survivors who had undergone ICR. Observed HRQOL deficits are possibly linked to the initial indication for ICR and rehabilitants may benefit from effective follow-up concepts after ICR.
1000 Sacherschließung
lokal Surveys and Questionnaires [MeSH]
lokal Health-related quality of life
lokal Posttraumatic growth
lokal Original Article – Clinical Oncology
lokal Humans [MeSH]
lokal Colorectal cancer
lokal Colorectal Neoplasms/epidemiology [MeSH]
lokal Cancer survivorship
lokal Inpatient rehabilitation
lokal Distress
lokal Quality of Life [MeSH]
lokal Posttraumatic Growth, Psychological [MeSH]
lokal Inpatients [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5554-1459|https://orcid.org/0000-0001-8004-4940|https://orcid.org/0000-0001-7290-906X|https://orcid.org/0000-0001-9320-8684|https://orcid.org/0000-0001-8919-1971|https://orcid.org/0000-0002-8307-3197|https://orcid.org/0000-0002-6129-1572
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1000 Erstellt am 2023-04-28T14:28:01.118+0200
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1000 Zuletzt bearbeitet Fri Oct 20 19:11:31 CEST 2023
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