Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A

  1. Ritter, Kristina
  2. Behrends, Jochen
  3. Erdmann, Hanna
  4. Rousseau, Jasmin
  5. Hölscher, Alexandra
  6. Volz, Johanna
  7. Prinz, Immo
  8. Lindenstrøm, Thomas
  9. Hölscher, Christoph ORCID logo

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1000 Titel
  • Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A
1000 Autor/in
  1. Ritter, Kristina |
  2. Behrends, Jochen |
  3. Erdmann, Hanna |
  4. Rousseau, Jasmin |
  5. Hölscher, Alexandra |
  6. Volz, Johanna |
  7. Prinz, Immo |
  8. Lindenstrøm, Thomas |
  9. Hölscher, Christoph |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-05
1000 Erschienen in
1000 Quellenangabe
  • 99(11):1585-1602
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-021-02100-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541990/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Interleukin (IL)-17A-producing T helper (Th)17 cells are increasingly being acknowledged to be associated with protective immunity to Mycobacterium tuberculosis (Mtb). Subunit vaccines potently promote protective immune responses against Mtb infection that correlate with an expansion of IL-23-dependent Th17 cells. Previous studies revealed that after vaccination, IL-23 is required for protection against challenge with Mtb but the underlying IL-23-dependent-and possibly IL-17A-mediated-mechanisms remain elusive. Therefore, we here analyzed the early outcome of Mtb infection in C57BL/6, IL-23p19-deficient (
1000 Sacherschließung
lokal Vaccines, Subunit/administration
lokal Female [MeSH]
lokal Interleukin-17/immunology [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal CD4-Positive T-Lymphocytes/drug effects [MeSH]
lokal Vaccination
lokal Mycobacterium tuberculosis/immunology [MeSH]
lokal Animals [MeSH]
lokal Interleukin-17/genetics [MeSH]
lokal Mice
lokal Mice, Knockout [MeSH]
lokal Cytokines
lokal Original Article
lokal CD4-Positive T-Lymphocytes/immunology [MeSH]
lokal Male [MeSH]
lokal Tuberculosis
lokal Tuberculosis Vaccines/administration
lokal T cells
lokal Antigens, Bacterial/administration
lokal Tuberculosis/prevention
lokal Interleukin-23/genetics [MeSH]
lokal Interleukin-23/immunology [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Uml0dGVyLCBLcmlzdGluYQ==|https://frl.publisso.de/adhoc/uri/QmVocmVuZHMsIEpvY2hlbg==|https://frl.publisso.de/adhoc/uri/RXJkbWFubiwgSGFubmE=|https://frl.publisso.de/adhoc/uri/Um91c3NlYXUsIEphc21pbg==|https://frl.publisso.de/adhoc/uri/SMO2bHNjaGVyLCBBbGV4YW5kcmE=|https://frl.publisso.de/adhoc/uri/Vm9seiwgSm9oYW5uYQ==|https://frl.publisso.de/adhoc/uri/UHJpbnosIEltbW8=|https://frl.publisso.de/adhoc/uri/TGluZGVuc3Ryw7htLCBUaG9tYXM=|https://orcid.org/0000-0002-7520-9146
1000 Hinweis
  • DeepGreen-ID: c837cf523ffe4744b09f8c8f9cdf1aa3 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6448281.rdf
1000 Erstellt am 2023-05-03T17:59:08.509+0200
1000 Erstellt von 322
1000 beschreibt frl:6448281
1000 Zuletzt bearbeitet 2023-10-20T22:20:49.134+0200
1000 Objekt bearb. Fri Oct 20 22:20:49 CEST 2023
1000 Vgl. frl:6448281
1000 Oai Id
  1. oai:frl.publisso.de:frl:6448281 |
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