Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

  1. Müller-Eigner, Annika ORCID logo
  2. Sanz-Moreno, Adrián ORCID logo
  3. de-Diego, Irene
  4. Venkatasubramani, Anuroop Venkateswaran
  5. Langhammer, Martina
  6. Gerlini, Raffaele ORCID logo
  7. Rathkolb, Birgit ORCID logo
  8. Aguilar-Pimentel, Juan Antonio ORCID logo
  9. Klein-Rodewald, Tanja
  10. Calzada-Wack, Julia
  11. Becker, Lore ORCID logo
  12. Palma-Vera, Sergio
  13. Gille, Benedikt ORCID logo
  14. Forne, Ignasi ORCID logo
  15. Imhof, Axel ORCID logo
  16. Meng, Chen
  17. Ludwig, Christina ORCID logo
  18. Koch, Franziska
  19. Heiker, John ORCID logo
  20. Kuhla, Angela
  21. Caton, Vanessa
  22. Brenmoehl, Julia ORCID logo
  23. Reyer, Henry
  24. Schoen, Jennifer
  25. Fuchs, Helmut ORCID logo
  26. Gailus-Durner, Valerie ORCID logo
  27. Hoeflich, Andreas ORCID logo
  28. Hrabe de Angelis, Martin ORCID logo
  29. Peleg, Shahaf ORCID logo

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1000 Titel
  • Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
1000 Autor/in
  1. Müller-Eigner, Annika |
  2. Sanz-Moreno, Adrián |
  3. de-Diego, Irene |
  4. Venkatasubramani, Anuroop Venkateswaran |
  5. Langhammer, Martina |
  6. Gerlini, Raffaele |
  7. Rathkolb, Birgit |
  8. Aguilar-Pimentel, Juan Antonio |
  9. Klein-Rodewald, Tanja |
  10. Calzada-Wack, Julia |
  11. Becker, Lore |
  12. Palma-Vera, Sergio |
  13. Gille, Benedikt |
  14. Forne, Ignasi |
  15. Imhof, Axel |
  16. Meng, Chen |
  17. Ludwig, Christina |
  18. Koch, Franziska |
  19. Heiker, John |
  20. Kuhla, Angela |
  21. Caton, Vanessa |
  22. Brenmoehl, Julia |
  23. Reyer, Henry |
  24. Schoen, Jennifer |
  25. Fuchs, Helmut |
  26. Gailus-Durner, Valerie |
  27. Hoeflich, Andreas |
  28. Hrabe de Angelis, Martin |
  29. Peleg, Shahaf |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-05-03
1000 Erschienen in
1000 Quellenangabe
  • 5(1):408
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s42003-022-03339-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065075/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s42003-022-03339-3#Sec28 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
1000 Sacherschließung
lokal Medicine (miscellaneous)
lokal Quality Indicators, Health Care [MeSH]
lokal Animals [MeSH]
lokal General Biochemistry, Genetics and Molecular Biology
lokal Physiology
lokal General Agricultural and Biological Sciences
lokal Molecular biology
lokal Mice [MeSH]
lokal Obesity/metabolism [MeSH]
lokal Mice, Obese [MeSH]
lokal Life Expectancy [MeSH]
lokal Phenotype [MeSH]
lokal Obesity/genetics [MeSH]
lokal Mice, Inbred Strains [MeSH]
lokal Biochemistry
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6138-2706|https://orcid.org/0000-0001-9478-5432|https://frl.publisso.de/adhoc/uri/ZGUtRGllZ28sIElyZW5l|https://frl.publisso.de/adhoc/uri/VmVua2F0YXN1YnJhbWFuaSwgQW51cm9vcCBWZW5rYXRlc3dhcmFu|https://frl.publisso.de/adhoc/uri/TGFuZ2hhbW1lciwgTWFydGluYQ==|https://orcid.org/0000-0003-0852-5621|https://orcid.org/0000-0003-1239-0547|https://orcid.org/0000-0002-4694-7107|https://frl.publisso.de/adhoc/uri/S2xlaW4tUm9kZXdhbGQsIFRhbmph|https://frl.publisso.de/adhoc/uri/Q2FsemFkYS1XYWNrLCBKdWxpYQ==|https://orcid.org/0000-0002-6890-4984|https://frl.publisso.de/adhoc/uri/UGFsbWEtVmVyYSwgU2VyZ2lv|https://orcid.org/0000-0002-3374-540X|https://orcid.org/0000-0003-0309-907X|https://orcid.org/0000-0003-2993-8249|https://frl.publisso.de/adhoc/uri/TWVuZywgQ2hlbg==|https://orcid.org/0000-0002-6131-7322|https://frl.publisso.de/adhoc/uri/S29jaCwgRnJhbnppc2th|https://orcid.org/0000-0003-2822-3006|https://frl.publisso.de/adhoc/uri/S3VobGEsIEFuZ2VsYQ==|https://frl.publisso.de/adhoc/uri/Q2F0b24sIFZhbmVzc2E=|https://orcid.org/0000-0002-7958-0655|https://frl.publisso.de/adhoc/uri/UmV5ZXIsIEhlbnJ5|https://frl.publisso.de/adhoc/uri/U2Nob2VuLCBKZW5uaWZlcg==|https://orcid.org/0000-0002-5143-2677|https://orcid.org/0000-0002-6076-0111|https://orcid.org/0000-0003-2018-2836|https://orcid.org/0000-0002-7898-2353|https://orcid.org/0000-0003-2646-3807
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1000 Erstellt am 2023-05-05T08:59:27.208+0200
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1000 Zuletzt bearbeitet 2023-05-23T08:42:41.630+0200
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