Antipsychotic drug use in pregnancy: A multinational study from ten countries

  1. Reutfors, Johan ORCID logo
  2. Cesta, Carolyn E.
  3. Cohen, Jacqueline M.
  4. Bateman, Brian T.
  5. Brauer, Ruth
  6. Einarsdóttir, Kristjana
  7. Engeland, Anders ORCID logo
  8. Furu, Kari
  9. Gissler, Mika
  10. Havard, Alys
  11. Hernandez-Diaz, Sonia
  12. Huybrechts, Krista F.
  13. Karlstad, Øystein
  14. Leinonen, Maarit K.
  15. Li, Jiong
  16. Man, Kenneth K.C.
  17. Pazzagli, Laura
  18. Schaffer, Andrea
  19. Schink, Tania ORCID logo
  20. Wang, Zixuan
  21. Yu, Yongfu
  22. Zoega, Helga
  23. Bröms, Gabriella

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WeightNameValue
1000 Titel
  • Antipsychotic drug use in pregnancy: A multinational study from ten countries
1000 Autor/in
  1. Reutfors, Johan |
  2. Cesta, Carolyn E. |
  3. Cohen, Jacqueline M. |
  4. Bateman, Brian T. |
  5. Brauer, Ruth |
  6. Einarsdóttir, Kristjana |
  7. Engeland, Anders |
  8. Furu, Kari |
  9. Gissler, Mika |
  10. Havard, Alys |
  11. Hernandez-Diaz, Sonia |
  12. Huybrechts, Krista F. |
  13. Karlstad, Øystein |
  14. Leinonen, Maarit K. |
  15. Li, Jiong |
  16. Man, Kenneth K.C. |
  17. Pazzagli, Laura |
  18. Schaffer, Andrea |
  19. Schink, Tania |
  20. Wang, Zixuan |
  21. Yu, Yongfu |
  22. Zoega, Helga |
  23. Bröms, Gabriella |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-04-12
1000 Erschienen in
1000 Quellenangabe
  • 220:106-115
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.schres.2020.03.048 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306443/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • AIM: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. METHODS: Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. RESULTS: We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. CONCLUSION: Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population.
1000 Sacherschließung
lokal Epidemiology
lokal Pregnancy
lokal Drug utilization study
lokal Antipsychotics
lokal Pharmacological treatment
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-1372-4262|https://frl.publisso.de/adhoc/uri/Q2VzdGEsIENhcm9seW4gRS4=|https://frl.publisso.de/adhoc/uri/Q29oZW4sIEphY3F1ZWxpbmUgTS4=|https://frl.publisso.de/adhoc/uri/QmF0ZW1hbiwgQnJpYW4gVC4=|https://frl.publisso.de/adhoc/uri/QnJhdWVyLCBSdXRo|https://frl.publisso.de/adhoc/uri/RWluYXJzZMOzdHRpciwgS3Jpc3RqYW5h|https://orcid.org/0000-0001-5620-9207|https://frl.publisso.de/adhoc/uri/RnVydSwgS2FyaQ==|https://frl.publisso.de/adhoc/uri/R2lzc2xlciwgTWlrYQ==|https://frl.publisso.de/adhoc/uri/SGF2YXJkLCBBbHlz|https://frl.publisso.de/adhoc/uri/SGVybmFuZGV6LURpYXosIFNvbmlh|https://frl.publisso.de/adhoc/uri/SHV5YnJlY2h0cywgS3Jpc3RhIEYu|https://frl.publisso.de/adhoc/uri/S2FybHN0YWQsIMOYeXN0ZWlu|https://frl.publisso.de/adhoc/uri/TGVpbm9uZW4sIE1hYXJpdCBLLg==|https://frl.publisso.de/adhoc/uri/TGksIEppb25n|https://frl.publisso.de/adhoc/uri/TWFuLCBLZW5uZXRoIEsuQy4=|https://frl.publisso.de/adhoc/uri/UGF6emFnbGksIExhdXJh|https://frl.publisso.de/adhoc/uri/U2NoYWZmZXIsIEFuZHJlYQ==|https://orcid.org/0000-0002-0224-1866|https://frl.publisso.de/adhoc/uri/V2FuZywgWml4dWFu|https://frl.publisso.de/adhoc/uri/WXUsIFlvbmdmdQ==|https://frl.publisso.de/adhoc/uri/Wm9lZ2EsIEhlbGdh|https://frl.publisso.de/adhoc/uri/QnLDtm1zLCBHYWJyaWVsbGE=
1000 Label
1000 Förderer
  1. NordForsk |
  2. Norges Forskningsråd |
  3. National Institute of Child Health and Human Development |
  4. Australian National Health and Medical Research Council |
  5. Region Stockholm |
  6. Svenska Läkaresällskapet |
1000 Fördernummer
  1. 83539
  2. 273366; 262700
  3. R21 HD092879
  4. 1028543
  5. -
  6. -
1000 Förderprogramm
  1. Nordic Pregnancy Drug Safety Studies (NorPreSS)
  2. International Pregnancy Drug Safety Studies
  3. -
  4. -
  5. -
  6. -
1000 Dateien
  1. Antipsychotic drug use in pregnancy: A multinational study from ten countries
    Antipsychotic drug use in pregnancy: A multinational study from ten countries
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer NordForsk |
    1000 Förderprogramm Nordic Pregnancy Drug Safety Studies (NorPreSS)
    1000 Fördernummer 83539
  2. 1000 joinedFunding-child
    1000 Förderer Norges Forskningsråd |
    1000 Förderprogramm International Pregnancy Drug Safety Studies
    1000 Fördernummer 273366; 262700
  3. 1000 joinedFunding-child
    1000 Förderer National Institute of Child Health and Human Development |
    1000 Förderprogramm -
    1000 Fördernummer R21 HD092879
  4. 1000 joinedFunding-child
    1000 Förderer Australian National Health and Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer 1028543
  5. 1000 joinedFunding-child
    1000 Förderer Region Stockholm |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Svenska Läkaresällskapet |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6449821.rdf
1000 Erstellt am 2023-05-09T10:16:25.668+0200
1000 Erstellt von 266
1000 beschreibt frl:6449821
1000 Bearbeitet von 337
1000 Zuletzt bearbeitet 2024-07-05T10:30:56.624+0200
1000 Objekt bearb. Fri Jul 05 10:30:56 CEST 2024
1000 Vgl. frl:6449821
1000 Oai Id
  1. oai:frl.publisso.de:frl:6449821 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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