Integrating genetics and metabolomics from multi- ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration

  1. Han, Xikun
  2. Lains, Ines
  3. Li, Jun
  4. Li, Jinglun
  5. Chen, Yiheng
  6. Yu, Bing
  7. Qi, Qibin
  8. Boerwinkle, Eric
  9. Kaplan, Robert
  10. Thyagarajan, Bharat
  11. Daviglus, Martha
  12. Joslin, Charlotte E.
  13. Cai, Jianwen
  14. Guasch-Ferré, Marta
  15. Tobias, Deirdre K.
  16. Rimm, Eric
  17. Ascherio, Alberto
  18. Costenbader, Karen
  19. Karlson, Elizabeth
  20. Mucci, Lorelei
  21. Eliassen, A. Heather
  22. Zeleznik, Oana
  23. Miller, John
  24. Vavvas, Demetrios G.
  25. Kim, Ivana K.
  26. Silva, Rufino
  27. Miller, Joan
  28. Hu, Frank
  29. Willett, Walter
  30. Lasky-Su, Jessica
  31. Kraft, Peter
  32. Richards, J. Brent
  33. MacGregor, Stuart
  34. Husain, Deeba
  35. Liang, Liming

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1000 Titel
  • Integrating genetics and metabolomics from multi- ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration
1000 Autor/in
  1. Han, Xikun |
  2. Lains, Ines |
  3. Li, Jun |
  4. Li, Jinglun |
  5. Chen, Yiheng |
  6. Yu, Bing |
  7. Qi, Qibin |
  8. Boerwinkle, Eric |
  9. Kaplan, Robert |
  10. Thyagarajan, Bharat |
  11. Daviglus, Martha |
  12. Joslin, Charlotte E. |
  13. Cai, Jianwen |
  14. Guasch-Ferré, Marta |
  15. Tobias, Deirdre K. |
  16. Rimm, Eric |
  17. Ascherio, Alberto |
  18. Costenbader, Karen |
  19. Karlson, Elizabeth |
  20. Mucci, Lorelei |
  21. Eliassen, A. Heather |
  22. Zeleznik, Oana |
  23. Miller, John |
  24. Vavvas, Demetrios G. |
  25. Kim, Ivana K. |
  26. Silva, Rufino |
  27. Miller, Joan |
  28. Hu, Frank |
  29. Willett, Walter |
  30. Lasky-Su, Jessica |
  31. Kraft, Peter |
  32. Richards, J. Brent |
  33. MacGregor, Stuart |
  34. Husain, Deeba |
  35. Liang, Liming |
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-21
1000 Erschienen in
1000 Quellenangabe
  • 4(7):101085
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.xcrm.2023.101085 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394104/ |
1000 Ergänzendes Material
  • https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00204-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379123002045%3Fshowall%3Dtrue#supplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic genetic and metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16,144 advanced AMD cases and 17,832 controls, we identify 108 putatively causal relationships between plasma metabolites and advanced AMD. These metabolites are enriched in glycerophospholipid metabolism, lysophospholipid, triradylcglycerol, and long chain polyunsaturated fatty acid pathways. Bayesian genetic colocalization analysis and a customized metabolome-wide association approach prioritize putative causal AMD-associated metabolites. We find limited evidence linking urine metabolites to AMD risk. Our study emphasizes the contribution of plasma metabolites, particularly lipid-related pathways and genes, to AMD risk and uncovers numerous putative causal associations between metabolites and AMD risk.
1000 Sacherschließung
lokal Mendelian randomization
lokal age-related macular degeneration
lokal genome-wide association studies
lokal metabolomics
lokal CLSA
lokal Hispanic Community Health Study/Study of Latinos
lokal HPFS
lokal Canadian Longitudinal Study of Aging
lokal HCHS/SOL
lokal genomics
lokal MR
lokal Health Professionals Follow Up Study
lokal NHS
lokal Nurses’ Health Study
lokal UK Biobank
lokal GWASs
lokal AMD
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. National Heart, Lung, and Blood Institute |
  2. University of Miami |
  3. Albert Einstein College of Medicine, Yeshiva University |
  4. University of Illinois at Chicago |
  5. San Diego State University |
  6. National Institute on Minority Health and Health Disparities |
  7. National Institute on Deafness and Other Communication Disorders |
  8. National Institute of Dental and Craniofacial Research |
  9. National Institute of Diabetes and Digestive and Kidney Diseases |
  10. National Institute of Neurological Disorders and Stroke |
  11. Genetic Analysis Center at the University of Washington |
  12. JLH Foundation |
1000 Fördernummer
  1. HHSN268201300001I/N01-HC-65233
  2. HHSN268201300004I/N01-HC-65234
  3. HHSN268201300002I/N01-HC-65235
  4. HHSN268201300003I/N01-HC-65236
  5. HHSN268201300005I/N01-HC-65237
  6. -
  7. -
  8. -
  9. -
  10. -
  11. HHSN268201300005C AM03;MOD03
  12. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Heart, Lung, and Blood Institute |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300001I/N01-HC-65233
  2. 1000 joinedFunding-child
    1000 Förderer University of Miami |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300004I/N01-HC-65234
  3. 1000 joinedFunding-child
    1000 Förderer Albert Einstein College of Medicine, Yeshiva University |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300002I/N01-HC-65235
  4. 1000 joinedFunding-child
    1000 Förderer University of Illinois at Chicago |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300003I/N01-HC-65236
  5. 1000 joinedFunding-child
    1000 Förderer San Diego State University |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300005I/N01-HC-65237
  6. 1000 joinedFunding-child
    1000 Förderer National Institute on Minority Health and Health Disparities |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer National Institute on Deafness and Other Communication Disorders |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer National Institute of Dental and Craniofacial Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer National Institute of Diabetes and Digestive and Kidney Diseases |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer National Institute of Neurological Disorders and Stroke |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Genetic Analysis Center at the University of Washington |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300005C AM03;MOD03
  12. 1000 joinedFunding-child
    1000 Förderer JLH Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6462087.rdf
1000 Erstellt am 2023-10-20T11:05:42.711+0200
1000 Erstellt von 337
1000 beschreibt frl:6462087
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2023-10-24T08:43:45.627+0200
1000 Objekt bearb. Tue Oct 24 08:43:16 CEST 2023
1000 Vgl. frl:6462087
1000 Oai Id
  1. oai:frl.publisso.de:frl:6462087 |
1000 Sichtbarkeit Metadaten public
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