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1000 Titel
  • Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis
1000 Autor/in
  1. Hagel, Stefan |
  2. Scherag, André |
  3. Schuierer, Lukas |
  4. Hoffmann, Reinhard |
  5. Luyt, Charles-Edouard |
  6. Pletz, Mathias W. |
  7. Kesselmeier, Miriam |
  8. Weis, Sebastian |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-29
1000 Erschienen in
1000 Quellenangabe
  • 24(1):584
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13054-020-03296-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522924/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients.!##!Methods!#!MEDLINE, ISI Web of Science, Cochrane Database and ClinicalTrials.gov were searched from inception to 25 May 2020. All clinical studies investigating the effects of antiviral therapy on the outcome of mechanically ventilated ICU patients in whom HSV was detected in the respiratory tract were eligible for inclusion, regardless of study design, publication status or language. Titles and abstracts were reviewed independently by two authors. If the articles seemed eligible, full-text articles were reviewed and data extracted. We performed a random-effects meta-analysis to estimate relative risks (RRs) with corresponding 95% confidence intervals (CIs). The primary endpoint was hospital all-cause mortality.!##!Results!#!Nine studies were included in the meta-analysis (one randomized controlled trial, eight cohort studies). Antiviral treatment was associated with lower hospital mortality (with antiviral treatment, 40.6% (189 out of 465 patients); without, 52.7% (193 out of 366 patients); RR 0.74 [0.64, 0.85]; eight studies, low quality of evidence). Furthermore, antiviral treatment was associated with lower 30-day mortality (RR 0.75 [0.59, 0.94]; three studies, very low quality of evidence). We did not observe evidence for differences in ICU mortality (RR 0.73 [0.51, 1.05]; three studies, very low quality of evidence).!##!Conclusions!#!This meta-analysis of the available data shows that antiviral therapy might result in lower hospital and 30-day all-cause mortality in mechanically ventilated ICU patients who are positive for HSV in the respiratory tract. However, this result must be interpreted with great caution due to the high risk of bias and limited number of patients. Large, well-designed randomized controlled clinical trials are urgently needed.!##!Trial registration!#!The study was registered in advance on International Prospective Register of Systematic Reviews (CRD42020180053) .
1000 Sacherschließung
lokal Hospital Mortality/trends [MeSH]
lokal Humans [MeSH]
lokal Simplexvirus/physiology [MeSH]
lokal Simplexvirus/pathogenicity [MeSH]
lokal Antiviral Agents/pharmacology [MeSH]
lokal Antiviral therapy
lokal Herpes simplex
lokal Simplexvirus/drug effects [MeSH]
lokal Respiration, Artificial/methods [MeSH]
lokal Antiviral Agents/standards [MeSH]
lokal Research
lokal Critically ill
lokal Antiviral Agents/therapeutic use [MeSH]
lokal Length of Stay/trends [MeSH]
lokal Respiratory System/virology [MeSH]
lokal Mechanical ventilation
lokal Respiratory System/drug effects [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-2999-6131|https://frl.publisso.de/adhoc/uri/U2NoZXJhZywgQW5kcsOp|https://frl.publisso.de/adhoc/uri/U2NodWllcmVyLCBMdWthcw==|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFJlaW5oYXJk|https://frl.publisso.de/adhoc/uri/THV5dCwgQ2hhcmxlcy1FZG91YXJk|https://frl.publisso.de/adhoc/uri/UGxldHosIE1hdGhpYXMgVy4=|https://frl.publisso.de/adhoc/uri/S2Vzc2VsbWVpZXIsIE1pcmlhbQ==|https://frl.publisso.de/adhoc/uri/V2VpcywgU2ViYXN0aWFu
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1000 Erstellt am 2023-11-15T16:31:14.995+0100
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