Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials

  1. Pazan, Farhad
  2. Petrovic, Mirko
  3. Cherubini, Antonio
  4. Onder, Graziano
  5. Cruz-Jentoft, Alfonso J.
  6. Denkinger, Michael
  7. van der Cammen, Tischa J. M.
  8. Stevenson, Jennifer M.
  9. Ibrahim, Kinda
  10. Rajkumar, Chakravarthi
  11. Bakken, Marit Stordal
  12. Baeyens, Jean-Pierre
  13. Crome, Peter
  14. Frühwald, Thomas
  15. Gallaghar, Paul
  16. Guðmundsson, Adalsteinn
  17. Knol, Wilma
  18. O’Mahony, Denis
  19. Pilotto, Alberto
  20. Rönnemaa, Elina
  21. Serra-Rexach, José Antonio
  22. Soulis, George
  23. van Marum, Rob J.
  24. Ziere, Gijsbertus
  25. Mair, Alpana
  26. Burkhardt, Heinrich
  27. Neumann-Podczaska, Agnieszka
  28. Wieczorowska-Tobis, Katarzyna
  29. Fernandes, Marilia Andreia
  30. Gruner, Heidi
  31. Dallmeier, Dhayana
  32. Beuscart, Jean-Baptiste
  33. van der Velde, Nathalie
  34. Family Name Deactivated, Given Names Deactivated ORCID logo

Download
s00228-020-02951-8.pdf 416,27KB
WeightNameValue
1000 Titel
  • Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials
1000 Autor/in
  1. Pazan, Farhad |
  2. Petrovic, Mirko |
  3. Cherubini, Antonio |
  4. Onder, Graziano |
  5. Cruz-Jentoft, Alfonso J. |
  6. Denkinger, Michael |
  7. van der Cammen, Tischa J. M. |
  8. Stevenson, Jennifer M. |
  9. Ibrahim, Kinda |
  10. Rajkumar, Chakravarthi |
  11. Bakken, Marit Stordal |
  12. Baeyens, Jean-Pierre |
  13. Crome, Peter |
  14. Frühwald, Thomas |
  15. Gallaghar, Paul |
  16. Guðmundsson, Adalsteinn |
  17. Knol, Wilma |
  18. O’Mahony, Denis |
  19. Pilotto, Alberto |
  20. Rönnemaa, Elina |
  21. Serra-Rexach, José Antonio |
  22. Soulis, George |
  23. van Marum, Rob J. |
  24. Ziere, Gijsbertus |
  25. Mair, Alpana |
  26. Burkhardt, Heinrich |
  27. Neumann-Podczaska, Agnieszka |
  28. Wieczorowska-Tobis, Katarzyna |
  29. Fernandes, Marilia Andreia |
  30. Gruner, Heidi |
  31. Dallmeier, Dhayana |
  32. Beuscart, Jean-Baptiste |
  33. van der Velde, Nathalie |
  34. Family Name Deactivated, Given Names Deactivated |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-08-07
1000 Erschienen in
1000 Quellenangabe
  • 77(1):1-12
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00228-020-02951-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197722/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty.!##!Methods!#!A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimization in older frail adults on comprehensive frailty scores or partial aspects of frailty that were published from January 1998 to October 2019.!##!Results!#!Twenty-five studies were identified, 4 on comprehensive frailty scores and 21 on aspects of frailty. Two trials on comprehensive frailty scores showed positive results on frailty although the contribution of medication review in a multidimensional approach was unclear. In the studies on aspects related to frailty, ten individual drug interventions showed improvement in physical performance, muscle strength or body composition utilizing alfacalcidol, teriparatide, piroxicam, testosterone, recombinant human chorionic gonadotropin, or capromorelin. There were no studies examining negative effects of drugs on frailty.!##!Conclusion!#!So far, data on a causal relationship between drugs and frailty are inconclusive or related to single-drug interventions on partial aspects of frailty. There is a clear need for RCTs on this topic that should be based on a comprehensive, internationally consistent and thus reproducible concept of frailty assessment.
1000 Sacherschließung
lokal Aged [MeSH]
lokal Frail Elderly [MeSH]
lokal Humans [MeSH]
lokal Older people
lokal Frailty/drug therapy [MeSH]
lokal Randomized Controlled Trials as Topic [MeSH]
lokal Medication optimization
lokal Polypharmacy
lokal Prefrailty
lokal Frailty
lokal Inappropriate drug treatment
lokal Review
lokal Polypharmacy [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGF6YW4sIEZhcmhhZA==|https://frl.publisso.de/adhoc/uri/UGV0cm92aWMsIE1pcmtv|https://frl.publisso.de/adhoc/uri/Q2hlcnViaW5pLCBBbnRvbmlv|https://frl.publisso.de/adhoc/uri/T25kZXIsIEdyYXppYW5v|https://frl.publisso.de/adhoc/uri/Q3J1ei1KZW50b2Z0LCBBbGZvbnNvIEou|https://frl.publisso.de/adhoc/uri/RGVua2luZ2VyLCBNaWNoYWVs|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBDYW1tZW4sIFRpc2NoYSBKLiBNLg==|https://frl.publisso.de/adhoc/uri/U3RldmVuc29uLCBKZW5uaWZlciBNLg==|https://frl.publisso.de/adhoc/uri/SWJyYWhpbSwgS2luZGE=|https://frl.publisso.de/adhoc/uri/UmFqa3VtYXIsIENoYWtyYXZhcnRoaQ==|https://frl.publisso.de/adhoc/uri/QmFra2VuLCBNYXJpdCBTdG9yZGFs|https://frl.publisso.de/adhoc/uri/QmFleWVucywgSmVhbi1QaWVycmU=|https://frl.publisso.de/adhoc/uri/Q3JvbWUsIFBldGVy|https://frl.publisso.de/adhoc/uri/RnLDvGh3YWxkLCBUaG9tYXM=|https://frl.publisso.de/adhoc/uri/R2FsbGFnaGFyLCBQYXVs|https://frl.publisso.de/adhoc/uri/R3XDsG11bmRzc29uLCBBZGFsc3RlaW5u|https://frl.publisso.de/adhoc/uri/S25vbCwgV2lsbWE=|https://frl.publisso.de/adhoc/uri/T_KAmU1haG9ueSwgRGVuaXM=|https://frl.publisso.de/adhoc/uri/UGlsb3R0bywgQWxiZXJ0bw==|https://frl.publisso.de/adhoc/uri/UsO2bm5lbWFhLCBFbGluYQ==|https://frl.publisso.de/adhoc/uri/U2VycmEtUmV4YWNoLCBKb3PDqSBBbnRvbmlv|https://frl.publisso.de/adhoc/uri/U291bGlzLCBHZW9yZ2U=|https://frl.publisso.de/adhoc/uri/dmFuIE1hcnVtLCBSb2IgSi4=|https://frl.publisso.de/adhoc/uri/WmllcmUsIEdpanNiZXJ0dXM=|https://frl.publisso.de/adhoc/uri/TWFpciwgQWxwYW5h|https://frl.publisso.de/adhoc/uri/QnVya2hhcmR0LCBIZWlucmljaA==|https://frl.publisso.de/adhoc/uri/TmV1bWFubi1Qb2RjemFza2EsIEFnbmllc3prYQ==|https://frl.publisso.de/adhoc/uri/V2llY3pvcm93c2thLVRvYmlzLCBLYXRhcnp5bmE=|https://frl.publisso.de/adhoc/uri/RmVybmFuZGVzLCBNYXJpbGlhIEFuZHJlaWE=|https://frl.publisso.de/adhoc/uri/R3J1bmVyLCBIZWlkaQ==|https://frl.publisso.de/adhoc/uri/RGFsbG1laWVyLCBEaGF5YW5h|https://frl.publisso.de/adhoc/uri/QmV1c2NhcnQsIEplYW4tQmFwdGlzdGU=|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBWZWxkZSwgTmF0aGFsaWU=|https://orcid.org/0000-0003-1393-1691
1000 Hinweis
  • DeepGreen-ID: 421b6b1450f14bedab7d61a228c11508 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6470176.rdf
1000 Erstellt am 2023-11-18T04:24:57.656+0100
1000 Erstellt von 322
1000 beschreibt frl:6470176
1000 Zuletzt bearbeitet 2023-12-01T11:17:20.212+0100
1000 Objekt bearb. Fri Dec 01 11:17:20 CET 2023
1000 Vgl. frl:6470176
1000 Oai Id
  1. oai:frl.publisso.de:frl:6470176 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source