Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study

  1. Dirven, Linda
  2. Luerding, Ralf
  3. Beier, Dagmar
  4. Bumes, Elisabeth
  5. Reinert, Christiane
  6. Seidel, Clemens
  7. Bonsanto, Matteo Mario
  8. Bremer, Michael
  9. Rieken, Stefan
  10. Combs, Stephanie E.
  11. Herrlinger, Ulrich
  12. Seliger, Corinna
  13. Kuntze, Holger
  14. Mayer-Steinacker, Regine
  15. Dieing, Annette
  16. Bartels, Claudius
  17. Schnell, Oliver
  18. Weyerbrock, Astrid
  19. Seidel, Sabine
  20. Grauer, Oliver
  21. Nadji-Ohl, Minou
  22. Paulsen, Frank
  23. Weller, Michael
  24. Wick, Wolfgang
  25. Hau, Peter

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1000 Titel
  • Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study
1000 Autor/in
  1. Dirven, Linda |
  2. Luerding, Ralf |
  3. Beier, Dagmar |
  4. Bumes, Elisabeth |
  5. Reinert, Christiane |
  6. Seidel, Clemens |
  7. Bonsanto, Matteo Mario |
  8. Bremer, Michael |
  9. Rieken, Stefan |
  10. Combs, Stephanie E. |
  11. Herrlinger, Ulrich |
  12. Seliger, Corinna |
  13. Kuntze, Holger |
  14. Mayer-Steinacker, Regine |
  15. Dieing, Annette |
  16. Bartels, Claudius |
  17. Schnell, Oliver |
  18. Weyerbrock, Astrid |
  19. Seidel, Sabine |
  20. Grauer, Oliver |
  21. Nadji-Ohl, Minou |
  22. Paulsen, Frank |
  23. Weller, Michael |
  24. Wick, Wolfgang |
  25. Hau, Peter |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-05-04
1000 Erschienen in
1000 Quellenangabe
  • 148(1):117-130
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11060-020-03502-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280359/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL).!##!Methods!#!Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL.!##!Results!#!28/30 patients were analyzed. The three preselected HRQoL scales (role, social and cognitive functioning) showed improved scores, to a clinically relevant extent (≥ 10 points), compared to post-treatment levels up to 30 months, but decreased afterwards. Z-scores for verbal working memory were worse during follow-up compared to post-treatment scores and remained impaired during 18 months follow-up (i.e. z-score below - 1 standard deviation). Attention was impaired post-treatment, and remained impaired to a clinically relevant extent during follow-up. Coordination/processing speed and lexical verbal fluency improved compared to post-treatment scores, and remained within the normal range thereafter. Other tests of verbal fluency were stable over time, with z-scores within the normal range.!##!Conclusions!#!This long-term follow-up study showed that the NOA-07 treatment regimen was not associated with a deterioration in HRQoL in the post-treatment period. Verbal working memory deteriorated, while other neurocognitive domains did not seem to be impacted negatively by the treatment.
1000 Sacherschließung
lokal Female [MeSH]
lokal Maintenance Chemotherapy/adverse effects [MeSH]
lokal Adult [MeSH]
lokal Medulloblastoma
lokal Humans [MeSH]
lokal Treatment Outcome [MeSH]
lokal Middle Aged [MeSH]
lokal Cerebellar Neoplasms/therapy [MeSH]
lokal Medulloblastoma/psychology [MeSH]
lokal Medulloblastoma/therapy [MeSH]
lokal Cerebellar Neoplasms/psychology [MeSH]
lokal Patient-reported outcome
lokal Quality of life
lokal Combined Modality Therapy/adverse effects [MeSH]
lokal Male [MeSH]
lokal Brain tumor
lokal Quality of Life [MeSH]
lokal Young Adult [MeSH]
lokal Toxicity
lokal Clinical Study
lokal Cognition
lokal Chemoradiotherapy/adverse effects [MeSH]
lokal Neuropsychological Tests [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-18T08:57:23.251+0100
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1000 Zuletzt bearbeitet Fri Dec 01 12:55:52 CET 2023
1000 Objekt bearb. Fri Dec 01 12:55:52 CET 2023
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