The IMAGEN study: a decade of imaging genetics in adolescents

  1. Mascarell Maričić, Lea
  2. Rosenthal, Annika
  3. Quinlan, Erin Burke ORCID logo
  4. Barker, Gareth ORCID logo
  5. Bokde, Arun L. W.
  6. Desrivières, Sylvane ORCID logo
  7. Itterman, Bernd
  8. Martinot, Marie-Laure Paillère
  9. Papadopoulos Orfanos, Dimitri ORCID logo
  10. Paus, Tomáš
  11. Hohmann, Sarah
  12. Smolka, Michael ORCID logo
  13. Fröhner, Juliane ORCID logo
  14. Kaminski, Jakob ORCID logo
  15. Schumann, Gunter ORCID logo
  16. Albrecht, Lisa
  17. Andrew, Chris
  18. Arroyo, Mercedes
  19. Artiges, Eric
  20. Aydin, Semiha
  21. Bach, Christine
  22. Banaschewski, Tobias
  23. Barbot, Alexis
  24. Barker, Gareth
  25. Boddaert, Nathalie
  26. Bokde, Arun
  27. Bricaud, Zuleima
  28. Bromberg, Uli
  29. Bruehl, Ruediger
  30. Büchel, Christian
  31. Cachia, Arnaud
  32. Cattrell, Anna
  33. Conrod, Patricia
  34. Constant, Patrick
  35. Dalley, Jeffrey
  36. Decideur, Benjamin
  37. Desrivieres, Sylvane
  38. Fadai, Tahmine
  39. Flor, Herta
  40. Frouin, Vincent
  41. Gallinat, Jürgen
  42. Garavan, Hugh
  43. Briand, Fanny Gollier
  44. Gowland, Penny
  45. Heinrichs, Bert
  46. Heinz, Andreas
  47. Heym, Nadja
  48. Hübner, Thomas
  49. Ireland, James
  50. Ittermann, Bernd
  51. Jia, Tianye
  52. Lathrop, Mark
  53. Lanzerath, Dirk
  54. Lawrence, Claire
  55. Lemaitre, Hervé
  56. Lüdemann, Katharina
  57. Macare, Christine
  58. Mallik, Catherine
  59. Mangin, Jean-François
  60. Mann, Karl
  61. Martinot, Jean-Luc
  62. Mennigen, Eva
  63. de Carvahlo, Fabiana Mesquita
  64. Mignon, Xavier
  65. Miranda, Ruben
  66. Müller, Kathrin
  67. Nees, Frauke
  68. Nymberg, Charlotte
  69. Paillere, Marie-Laure
  70. Paus, Tomas
  71. Pausova, Zdenka
  72. Poline, Jean-Baptiste
  73. Poustka, Luise
  74. Rapp, Michael
  75. Robert, Gabriel
  76. Reuter, Jan
  77. Rietschel, Marcella
  78. Ripke, Stephan
  79. Robbins, Trevor
  80. Rodehacke, Sarah
  81. Rogers, John
  82. Romanowski, Alexander
  83. Ruggeri, Barbara
  84. Schmäl, Christine
  85. Schmidt, Dirk
  86. Schneider, Sophia
  87. Schumann, MarkGunter
  88. Schubert, Florian
  89. Schwartz, Yannick
  90. Smolka, Michael
  91. Sommer, Wolfgang
  92. Spanagel, Rainer
  93. Speiser, Claudia
  94. Spranger, Tade
  95. Stedman, Alicia
  96. Steiner, Sabina
  97. Stephens, Dai
  98. Strache, Nicole
  99. Ströhle, Andreas
  100. Struve, Maren
  101. Subramaniam, Naresh
  102. Topper, Lauren
  103. Walter, Henrik
  104. Whelan, Robert
  105. Williams, Steve
  106. Yacubian, Juliana
  107. Zilbovicius, Monica
  108. Wong, C. Peng
  109. Lubbe, Steven
  110. Martinez-Medina, Lourdes
  111. Fernandes, Alinda
  112. Tahmasebi, Amir

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1000 Titel
  • The IMAGEN study: a decade of imaging genetics in adolescents
1000 Autor/in
  1. Mascarell Maričić, Lea |
  2. Rosenthal, Annika |
  3. Quinlan, Erin Burke |
  4. Barker, Gareth |
  5. Bokde, Arun L. W. |
  6. Desrivières, Sylvane |
  7. Itterman, Bernd |
  8. Martinot, Marie-Laure Paillère |
  9. Papadopoulos Orfanos, Dimitri |
  10. Paus, Tomáš |
  11. Hohmann, Sarah |
  12. Smolka, Michael |
  13. Fröhner, Juliane |
  14. Kaminski, Jakob |
  15. Schumann, Gunter |
  16. Albrecht, Lisa |
  17. Andrew, Chris |
  18. Arroyo, Mercedes |
  19. Artiges, Eric |
  20. Aydin, Semiha |
  21. Bach, Christine |
  22. Banaschewski, Tobias |
  23. Barbot, Alexis |
  24. Barker, Gareth |
  25. Boddaert, Nathalie |
  26. Bokde, Arun |
  27. Bricaud, Zuleima |
  28. Bromberg, Uli |
  29. Bruehl, Ruediger |
  30. Büchel, Christian |
  31. Cachia, Arnaud |
  32. Cattrell, Anna |
  33. Conrod, Patricia |
  34. Constant, Patrick |
  35. Dalley, Jeffrey |
  36. Decideur, Benjamin |
  37. Desrivieres, Sylvane |
  38. Fadai, Tahmine |
  39. Flor, Herta |
  40. Frouin, Vincent |
  41. Gallinat, Jürgen |
  42. Garavan, Hugh |
  43. Briand, Fanny Gollier |
  44. Gowland, Penny |
  45. Heinrichs, Bert |
  46. Heinz, Andreas |
  47. Heym, Nadja |
  48. Hübner, Thomas |
  49. Ireland, James |
  50. Ittermann, Bernd |
  51. Jia, Tianye |
  52. Lathrop, Mark |
  53. Lanzerath, Dirk |
  54. Lawrence, Claire |
  55. Lemaitre, Hervé |
  56. Lüdemann, Katharina |
  57. Macare, Christine |
  58. Mallik, Catherine |
  59. Mangin, Jean-François |
  60. Mann, Karl |
  61. Martinot, Jean-Luc |
  62. Mennigen, Eva |
  63. de Carvahlo, Fabiana Mesquita |
  64. Mignon, Xavier |
  65. Miranda, Ruben |
  66. Müller, Kathrin |
  67. Nees, Frauke |
  68. Nymberg, Charlotte |
  69. Paillere, Marie-Laure |
  70. Paus, Tomas |
  71. Pausova, Zdenka |
  72. Poline, Jean-Baptiste |
  73. Poustka, Luise |
  74. Rapp, Michael |
  75. Robert, Gabriel |
  76. Reuter, Jan |
  77. Rietschel, Marcella |
  78. Ripke, Stephan |
  79. Robbins, Trevor |
  80. Rodehacke, Sarah |
  81. Rogers, John |
  82. Romanowski, Alexander |
  83. Ruggeri, Barbara |
  84. Schmäl, Christine |
  85. Schmidt, Dirk |
  86. Schneider, Sophia |
  87. Schumann, MarkGunter |
  88. Schubert, Florian |
  89. Schwartz, Yannick |
  90. Smolka, Michael |
  91. Sommer, Wolfgang |
  92. Spanagel, Rainer |
  93. Speiser, Claudia |
  94. Spranger, Tade |
  95. Stedman, Alicia |
  96. Steiner, Sabina |
  97. Stephens, Dai |
  98. Strache, Nicole |
  99. Ströhle, Andreas |
  100. Struve, Maren |
  101. Subramaniam, Naresh |
  102. Topper, Lauren |
  103. Walter, Henrik |
  104. Whelan, Robert |
  105. Williams, Steve |
  106. Yacubian, Juliana |
  107. Zilbovicius, Monica |
  108. Wong, C. Peng |
  109. Lubbe, Steven |
  110. Martinez-Medina, Lourdes |
  111. Fernandes, Alinda |
  112. Tahmasebi, Amir |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-29
1000 Erschienen in
1000 Quellenangabe
  • 25(11):2648-2671
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-020-0822-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577859/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Neuroscience
lokal Humans [MeSH]
lokal Multicenter Studies as Topic [MeSH]
lokal Time Factors [MeSH]
lokal Cohort Studies [MeSH]
lokal Genetics [MeSH]
lokal Perspective
lokal Reproducibility of Results [MeSH]
lokal Neuroimaging [MeSH]
lokal Reward [MeSH]
lokal Psychology
lokal Adolescent Behavior [MeSH]
1000 Liste der Beteiligten
  1. 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1000 Dateien
  1. The IMAGEN study: a decade of imaging genetics in adolescents
    The IMAGEN study: a decade of imaging genetics in adolescents
1000 Objektart article
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1000 Erstellt am 2023-11-18T10:49:15.752+0100
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