Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a Longitudinal Observational Study (DynaM-OBS)

  1. Wackerhagen, Carolin ORCID logo
  2. Veer, Ilya ORCID logo
  3. van leeuwen, Judith ORCID logo
  4. Reppmann, Zala ORCID logo
  5. Riepenhausen, Antje ORCID logo
  6. Bögemann, Sophie ORCID logo
  7. Mor, Netali ORCID logo
  8. Puhlmann, Lara MC ORCID logo
  9. Uściłko, Aleksandra ORCID logo
  10. Zerban, Matthias ORCID logo
  11. Mituniewicz, Julian ORCID logo
  12. Lerner, Avigail ORCID logo
  13. Yuen, Kenneth ORCID logo
  14. Köber, Göran ORCID logo
  15. Marciniak, Marta ORCID logo
  16. Pooseh, Shakoor ORCID logo
  17. Weermeijer, Jeroen ORCID logo
  18. Arias-Vasquez, Alejandro ORCID logo
  19. Binder, Harald ORCID logo
  20. De Raedt, Walter ORCID logo
  21. Kleim, Birgit ORCID logo
  22. Myin-Germeys, Inez ORCID logo
  23. Roelofs, Karin ORCID logo
  24. Timmer, Jens ORCID logo
  25. Tuescher, Oliver ORCID logo
  26. Hendler, Talma ORCID logo
  27. Kobylińska, Dorota ORCID logo
  28. Hermans, Erno ORCID logo
  29. Kalisch, Raffael ORCID logo
  30. Walter, Henrik ORCID logo

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Dynamic Modelling of Mental Resilience in Young Adults.pdf 407,22KB
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1000 Titel
  • Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a Longitudinal Observational Study (DynaM-OBS)
1000 Autor/in
  1. Wackerhagen, Carolin |
  2. Veer, Ilya |
  3. van leeuwen, Judith |
  4. Reppmann, Zala |
  5. Riepenhausen, Antje |
  6. Bögemann, Sophie |
  7. Mor, Netali |
  8. Puhlmann, Lara MC |
  9. Uściłko, Aleksandra |
  10. Zerban, Matthias |
  11. Mituniewicz, Julian |
  12. Lerner, Avigail |
  13. Yuen, Kenneth |
  14. Köber, Göran |
  15. Marciniak, Marta |
  16. Pooseh, Shakoor |
  17. Weermeijer, Jeroen |
  18. Arias-Vasquez, Alejandro |
  19. Binder, Harald |
  20. De Raedt, Walter |
  21. Kleim, Birgit |
  22. Myin-Germeys, Inez |
  23. Roelofs, Karin |
  24. Timmer, Jens |
  25. Tuescher, Oliver |
  26. Hendler, Talma |
  27. Kobylińska, Dorota |
  28. Hermans, Erno |
  29. Kalisch, Raffael |
  30. Walter, Henrik |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-07-04
1000 Erschienen in
1000 Quellenangabe
  • 12:e39817
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.2196/39817 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354714/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psychological resilience in healthy but susceptible young adults over 9 months. Resilience is conceptualized in this study as the maintenance of mental health or quick recovery from mental health perturbations upon exposure to stressors, assessed longitudinally via frequent monitoring of stressors and mental health.!##!Objective!#!This study aims to investigate the factors predicting mental resilience and adaptive processes and mechanisms contributing to mental resilience and to provide a methodological and evidence-based framework for later intervention studies.!##!Methods!#!In a multicenter setting, across 5 research sites, a sample with a total target size of 250 young male and female adults was assessed longitudinally over 9 months. Participants were included if they reported at least 3 past stressful life events and an elevated level of (internalizing) mental health problems but were not presently affected by any mental disorder other than mild depression. At baseline, sociodemographic, psychological, neuropsychological, structural, and functional brain imaging; salivary cortisol and α-amylase levels; and cardiovascular data were acquired. In a 6-month longitudinal phase 1, stressor exposure, mental health problems, and perceived positive appraisal were monitored biweekly in a web-based environment, while ecological momentary assessments and ecological physiological assessments took place once per month for 1 week, using mobile phones and wristbands. In a subsequent 3-month longitudinal phase 2, web-based monitoring was reduced to once a month, and psychological resilience and risk factors were assessed again at the end of the 9-month period. In addition, samples for genetic, epigenetic, and microbiome analyses were collected at baseline and at months 3 and 6. As an approximation of resilience, an individual stressor reactivity score will be calculated. Using regularized regression methods, network modeling, ordinary differential equations, landmarking methods, and neural net-based methods for imputation and dimension reduction, we will identify the predictors and mechanisms of stressor reactivity and thus be able to identify resilience factors and mechanisms that facilitate adaptation to stressors.!##!Results!#!Participant inclusion began in October 2020, and data acquisition was completed in June 2022. A total of 249 participants were assessed at baseline, 209 finished longitudinal phase 1, and 153 finished longitudinal phase 2.!##!Conclusions!#!The Dynamic Modelling of Resilience-Observational Study provides a methodological framework and data set to identify predictors and mechanisms of mental resilience, which are intended to serve as an empirical foundation for future intervention studies.!##!International registered report identifier (irrid)!#!DERR1-10.2196/39817.
1000 Sacherschließung
lokal General Medicine
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5689-3472|https://orcid.org/0000-0002-6733-3593|https://orcid.org/0000-0002-7750-1255|https://orcid.org/0000-0001-8633-9651|https://orcid.org/0000-0001-8749-5349|https://orcid.org/0000-0001-9382-0769|https://orcid.org/0000-0002-3759-5680|https://orcid.org/0000-0002-0870-8770|https://orcid.org/0000-0002-0001-7190|https://orcid.org/0000-0002-2684-3271|https://orcid.org/0000-0002-9717-5784|https://orcid.org/0009-0003-0081-5912|https://orcid.org/0000-0002-9465-9070|https://orcid.org/0000-0001-7038-0860|https://orcid.org/0000-0003-4301-3269|https://orcid.org/0000-0002-5441-9507|https://orcid.org/0000-0002-6288-795X|https://orcid.org/0000-0002-4786-0169|https://orcid.org/0000-0002-5666-8662|https://orcid.org/0000-0002-7117-7976|https://orcid.org/0000-0001-9114-2917|https://orcid.org/0000-0002-3731-4930|https://orcid.org/0000-0002-8863-8978|https://orcid.org/0000-0003-4517-1383|https://orcid.org/0000-0002-4023-5301|https://orcid.org/0000-0002-4182-4335|https://orcid.org/0000-0003-0184-2595|https://orcid.org/0000-0003-1339-8639|https://orcid.org/0000-0002-9503-7601|https://orcid.org/0000-0002-9403-6121
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1000 Erstellt am 2023-12-14T08:07:02.619+0100
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