A complex intervention to prevent medication-related hospital admissions: Results of the stepped-wedge cluster-randomized trial KiDSafe in pediatrics

  1. Neubert, Antje
  2. Toni, Irmgard
  3. König, Jochem
  4. Malonga Makosi, Dorothée
  5. Mildenberger, Philipp
  6. Romanos, Marcel
  7. Bertsche, Astrid
  8. Bertsche, Thilo
  9. Dahlem, Peter
  10. Egberts, Karin
  11. Erdlenbruch, Bernhard
  12. Fekete, Stefanie
  13. Haug, Ulrike ORCID logo
  14. Horneff, Gerd
  15. Hübler, Axel
  16. Kiess, Wieland
  17. Neininger, Martina P.
  18. Niehues, Tim
  19. Sachs, Bernhardt
  20. Schettler, Karl Florian
  21. Schreeck, Filipa
  22. Steimle, Tim
  23. Wenzl, Tobias
  24. Wirth, Stefan
  25. Zepp, Fred
  26. Schwab, Matthias
  27. Urschwitz, Michael S.
  28. Rascher, Wolfgang
  29. Das KiDSafe Konsortium

WeightNameValue
1000 Titel
  • A complex intervention to prevent medication-related hospital admissions: Results of the stepped-wedge cluster-randomized trial KiDSafe in pediatrics
1000 Autor/in
  1. Neubert, Antje |
  2. Toni, Irmgard |
  3. König, Jochem |
  4. Malonga Makosi, Dorothée |
  5. Mildenberger, Philipp |
  6. Romanos, Marcel |
  7. Bertsche, Astrid |
  8. Bertsche, Thilo |
  9. Dahlem, Peter |
  10. Egberts, Karin |
  11. Erdlenbruch, Bernhard |
  12. Fekete, Stefanie |
  13. Haug, Ulrike |
  14. Horneff, Gerd |
  15. Hübler, Axel |
  16. Kiess, Wieland |
  17. Neininger, Martina P. |
  18. Niehues, Tim |
  19. Sachs, Bernhardt |
  20. Schettler, Karl Florian |
  21. Schreeck, Filipa |
  22. Steimle, Tim |
  23. Wenzl, Tobias |
  24. Wirth, Stefan |
  25. Zepp, Fred |
  26. Schwab, Matthias |
  27. Urschwitz, Michael S. |
  28. Rascher, Wolfgang |
1000 Mitwirkende/r
  1. Das KiDSafe Konsortium |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-23
1000 Erschienen in
1000 Quellenangabe
  • 120(25):425-431
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478767/ |
  • https://doi.org/10.3238%2Farztebl.m2023.0123 |
1000 Ergänzendes Material
  • http://www.aerzteblatt-international.de/m2023.0123 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Children are often treated off-label and are at a disadvantage in pharmacotherapy. The aim of this study was to implement and evaluate a quality assurance measure (PaedPharm) for pediatric pharmacotherapy whose purpose is to reduce medication-related hospitalizations among children and adolescents. METHODS: PaedPharm consisted of the digital pediatric drug information system PaedAMIS, pediatric pharmaceutical quality circles (PaedZirk), and an adverse drug event (ADE) reporting system (PaedReport). The intervention was implemented in a cluster-randomized trial (DRKS 00013924) in 12 regions, with a pediatric and adolescent medicine clinic in each and a total of 152 surrounding private practitioners, in 6 sequences over 8 quarters. In addition to the proportion of ADE-related hospital admissions (primary endpoint), comprehensive process evaluation included other endpoints such as coverage, user acceptance, and relevance to practice. RESULTS: 41 829 inpatient admissions were recorded, of which 5101 were patients of physicians who participated in our study. 4.1% of admissions were ADE-related under control conditions, and 3.1% under intervention conditions (95% CI: [2.3; 5.9] and [1.8; 4.5], respectively). A model-based comparison yielded an intervention effect of 0.73 (population-based odds ratio; [0.39; 1.37]; p = 0.33). PaedAMIS achieved moderate user acceptance and PaedZirk achieved high user acceptance. CONCLUSION: The introduction of PaedPharm was associated with a decrease in medication-related hospitalizations that did not reach statistical significance. The process evaluation revealed broad acceptance of the intervention in outpatient pediatrics and adolescent medicine.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Gemeinsame Bundesausschuss |
  2. Bundesministerium für Gesundheit |
  3. Robert Bosch Stiftung |
1000 Fördernummer
  1. 01NVF16021
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Gemeinsame Bundesausschuss |
    1000 Förderprogramm -
    1000 Fördernummer 01NVF16021
  2. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Gesundheit |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Robert Bosch Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6473008.rdf
1000 Erstellt am 2024-01-30T12:01:44.765+0100
1000 Erstellt von 266
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1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Feb 05 13:36:54 CET 2024
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1000 Oai Id
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