The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation

  1. Kang, Eun-Jung ORCID logo
  2. Kim, Jae-Hoon
  3. Kim, Young Eun
  4. Lee, Hana ORCID logo
  5. Jung, Kwang Bo ORCID logo
  6. Chang, Dong-Ho
  7. Lee, Youngjin
  8. Park, Shinhye
  9. Lee, Eun-Young ORCID logo
  10. Lee, Eun-Ji
  11. Kang, Ho Bum
  12. Rhyoo, Moon-Young
  13. Seo, Seungwoo ORCID logo
  14. Park, Sohee
  15. Huh, Yubin
  16. Go, Jun
  17. Choi, Jung Hyeon
  18. Choi, Young-Keun
  19. Lee, In-Bok
  20. Choi, Dong-Hee
  21. Seo, Yun Jeong
  22. Noh, Jung-Ran
  23. Kim, Kyoung-Shim ORCID logo
  24. Hwang, Jung Hwan
  25. Jeong, Ji-Seon ORCID logo
  26. Kwon, Ha-Jeong ORCID logo
  27. Yoo, Hee Min ORCID logo
  28. Son, Mi-Young ORCID logo
  29. Kim, Yeon-Gu
  30. Lee, Dae-Hee ORCID logo
  31. Kim, Tae-Young ORCID logo
  32. Kwon, Hyo-Jung ORCID logo
  33. Kim, Myung Hee ORCID logo
  34. Kim, Byoung-Chan
  35. Kim, Yong-Hoon ORCID logo
  36. Kang, Dukjin ORCID logo
  37. Lee, Chul-Ho ORCID logo

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WeightNameValue
1000 Titel
  • The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation
1000 Autor/in
  1. Kang, Eun-Jung |
  2. Kim, Jae-Hoon |
  3. Kim, Young Eun |
  4. Lee, Hana |
  5. Jung, Kwang Bo |
  6. Chang, Dong-Ho |
  7. Lee, Youngjin |
  8. Park, Shinhye |
  9. Lee, Eun-Young |
  10. Lee, Eun-Ji |
  11. Kang, Ho Bum |
  12. Rhyoo, Moon-Young |
  13. Seo, Seungwoo |
  14. Park, Sohee |
  15. Huh, Yubin |
  16. Go, Jun |
  17. Choi, Jung Hyeon |
  18. Choi, Young-Keun |
  19. Lee, In-Bok |
  20. Choi, Dong-Hee |
  21. Seo, Yun Jeong |
  22. Noh, Jung-Ran |
  23. Kim, Kyoung-Shim |
  24. Hwang, Jung Hwan |
  25. Jeong, Ji-Seon |
  26. Kwon, Ha-Jeong |
  27. Yoo, Hee Min |
  28. Son, Mi-Young |
  29. Kim, Yeon-Gu |
  30. Lee, Dae-Hee |
  31. Kim, Tae-Young |
  32. Kwon, Hyo-Jung |
  33. Kim, Myung Hee |
  34. Kim, Byoung-Chan |
  35. Kim, Yong-Hoon |
  36. Kang, Dukjin |
  37. Lee, Chul-Ho |
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-04-06
1000 Erschienen in
1000 Quellenangabe
  • 15(1):2983
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-024-47275-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998920/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-024-47275-8#Sec38 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating gut immunity, promoting intestinal epithelial development, and improving barrier integrity. However, A. muciniphila-derived functional molecules regulating gut health are not well understood. Microbiome-secreted proteins act as key arbitrators of host-microbiome crosstalk through interactions with host cells in the gut and are important for understanding host-microbiome relationships. Herein, we report the biological function of Amuc_1409, a previously uncharacterised A. muciniphila-secreted protein. Amuc_1409 increased intestinal stem cell (ISC) proliferation and regeneration in ex vivo intestinal organoids and in vivo models of radiation- or chemotherapeutic drug-induced intestinal injury and natural aging with male mice. Mechanistically, Amuc_1409 promoted E-cadherin/β-catenin complex dissociation via interaction with E-cadherin, resulting in the activation of Wnt/β-catenin signaling. Our results demonstrate that Amuc_1409 plays a crucial role in intestinal homeostasis by regulating ISC activity in an E-cadherin-dependent manner and is a promising biomolecule for improving and maintaining gut health.
1000 Sacherschließung
lokal Gastroenterology
lokal Microbiology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0009-0006-0144-481X|https://frl.publisso.de/adhoc/uri/S2ltLCBKYWUtSG9vbg==|https://frl.publisso.de/adhoc/uri/S2ltLCBZb3VuZyBFdW4=|https://orcid.org/0000-0001-7782-5711|https://orcid.org/0000-0002-2112-6249|https://frl.publisso.de/adhoc/uri/Q2hhbmcsIERvbmctSG8=|https://frl.publisso.de/adhoc/uri/TGVlLCBZb3VuZ2ppbg==|https://frl.publisso.de/adhoc/uri/UGFyaywgU2hpbmh5ZQ==|https://orcid.org/0000-0003-3120-9192|https://frl.publisso.de/adhoc/uri/TGVlLCBFdW4tSmk=|https://frl.publisso.de/adhoc/uri/S2FuZywgSG8gQnVt|https://frl.publisso.de/adhoc/uri/Umh5b28sIE1vb24tWW91bmc=|https://orcid.org/0000-0003-4218-3602|https://frl.publisso.de/adhoc/uri/UGFyaywgU29oZWU=|https://frl.publisso.de/adhoc/uri/SHVoLCBZdWJpbg==|https://frl.publisso.de/adhoc/uri/R28sIEp1bg==|https://frl.publisso.de/adhoc/uri/Q2hvaSwgSnVuZyBIeWVvbg==|https://frl.publisso.de/adhoc/uri/Q2hvaSwgWW91bmctS2V1bg==|https://frl.publisso.de/adhoc/uri/TGVlLCBJbi1Cb2s=|https://frl.publisso.de/adhoc/uri/Q2hvaSwgRG9uZy1IZWU=|https://frl.publisso.de/adhoc/uri/U2VvLCBZdW4gSmVvbmc=|https://frl.publisso.de/adhoc/uri/Tm9oLCBKdW5nLVJhbg==|https://orcid.org/0000-0001-6636-8359|https://frl.publisso.de/adhoc/uri/SHdhbmcsIEp1bmcgSHdhbg==|https://orcid.org/0000-0002-9750-981X|https://orcid.org/0000-0002-7133-5401|https://orcid.org/0000-0002-5951-2137|https://orcid.org/0000-0001-7590-8812|https://frl.publisso.de/adhoc/uri/S2ltLCBZZW9uLUd1|https://orcid.org/0000-0002-0423-9057|https://orcid.org/0000-0002-8846-3338|https://orcid.org/0000-0001-5927-1970|https://orcid.org/0000-0003-2856-9066|https://frl.publisso.de/adhoc/uri/S2ltLCBCeW91bmctQ2hhbg==|https://orcid.org/0000-0002-0682-2238|https://orcid.org/0000-0002-5924-9674|https://orcid.org/0000-0002-6996-5746
1000 Label
1000 Förderer
  1. National Research Foundation of Korea |
  2. Korea Research Institute of Bioscience and Biotechnology |
1000 Fördernummer
  1. 2019M3A9F3065867
  2. KGS1062423
1000 Förderprogramm
  1. Bio & Medical Technology Development Program
  2. Research Initiative Program
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Research Foundation of Korea |
    1000 Förderprogramm Bio & Medical Technology Development Program
    1000 Fördernummer 2019M3A9F3065867
  2. 1000 joinedFunding-child
    1000 Förderer Korea Research Institute of Bioscience and Biotechnology |
    1000 Förderprogramm Research Initiative Program
    1000 Fördernummer KGS1062423
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6474081.rdf
1000 Erstellt am 2024-04-08T13:41:57.915+0200
1000 Erstellt von 284
1000 beschreibt frl:6474081
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2024-04-12T11:40:57.206+0200
1000 Objekt bearb. Fri Apr 12 11:40:44 CEST 2024
1000 Vgl. frl:6474081
1000 Oai Id
  1. oai:frl.publisso.de:frl:6474081 |
1000 Sichtbarkeit Metadaten public
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