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1000 Titel
  • Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
1000 Autor/in
  1. Kochlik, Bastian |
  2. Herpich, Catrin |
  3. Moreno‐Villanueva, Maria |
  4. Klaus, Susanne |
  5. Müller-Werdan, Ursula |
  6. Weinberger, Birgit |
  7. Fiegl, Simone |
  8. Toussaint, Olivier |
  9. Debacq-Chainiaux, Florence |
  10. Schön, Christiane |
  11. Bernhard, Jürgen |
  12. Breusing, Nicolle |
  13. Gonos, Efstathios S. |
  14. Franceschi, Claudio |
  15. Capri, Miriam |
  16. Sikora, Ewa |
  17. Hervonen, Antti |
  18. Hurme, Mikko |
  19. Slagboom, Pieternella |
  20. Dollé, Martijn |
  21. Jansen, Eugene |
  22. Grune, Tilman |
  23. Bürkle, Alexander |
  24. Norman, Kristina |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-09-16
1000 Erschienen in
1000 Quellenangabe
  • 46(2):1657-1669
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11357-023-00902-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828354/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s11357-023-00902-6#Sec12 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (N = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310], p = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372], p = 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951], p = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.
1000 Sacherschließung
lokal Aging
lokal GDF15
lokal Depression
lokal Cognitive frailty
lokal Biomarker
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-0214-7092|http://orcid.org/0000-0003-3059-1705|https://frl.publisso.de/adhoc/uri/TW9yZW5v4oCRVmlsbGFudWV2YSwgTWFyaWE=|http://orcid.org/0000-0001-8726-185X|http://orcid.org/0000-0003-4440-8991|http://orcid.org/0000-0002-7084-946X|https://frl.publisso.de/adhoc/uri/RmllZ2wsIFNpbW9uZQ==|https://frl.publisso.de/adhoc/uri/VG91c3NhaW50LCBPbGl2aWVy|http://orcid.org/0000-0003-3949-395X|http://orcid.org/0000-0003-3787-5268|https://frl.publisso.de/adhoc/uri/QmVybmhhcmQsIErDvHJnZW4=|https://frl.publisso.de/adhoc/uri/QnJldXNpbmcsIE5pY29sbGU=|https://frl.publisso.de/adhoc/uri/R29ub3MsIEVmc3RhdGhpb3MgUy4=|http://orcid.org/0000-0001-9841-6386|http://orcid.org/0000-0001-9077-0401|http://orcid.org/0000-0002-1111-1748|https://frl.publisso.de/adhoc/uri/SGVydm9uZW4sIEFudHRp|http://orcid.org/0000-0002-8614-1044|http://orcid.org/0000-0002-2875-4723|http://orcid.org/0000-0001-6137-6544|http://orcid.org/0000-0002-3151-5897|http://orcid.org/0000-0003-4775-9973|http://orcid.org/0000-0003-1069-2656|http://orcid.org/0000-0003-2029-9102
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