Download
Obesity - 2023 - Ouni - Novel markers and networks related to restored skeletal muscle transcriptome after bariatric.pdf 3,47MB
WeightNameValue
1000 Titel
  • Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery
1000 Autor/in
  1. Ouni, Meriem |
  2. Kovac, Leona |
  3. Gancheva, Sofiya |
  4. Jähnert, Markus |
  5. Zuljan, Erika |
  6. Gottmann, Pascal |
  7. Kahl, Sabine |
  8. De Angelis, Martin Hrabĕ |
  9. Roden, Michael |
  10. Schürmann, Annette |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-12-12
1000 Erschienen in
1000 Quellenangabe
  • 32(2):363-375
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/oby.23954 |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/full/10.1002/oby.23954#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: The aim of this study was to discover novel markers underlying the improvement of skeletal muscle metabolism after bariatric surgery. METHODS: Skeletal muscle transcriptome data of lean people and people with obesity, before and 1 year after bariatric surgery, were subjected to weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression. Results of LASSO were confirmed in a replication cohort. RESULTS: The expression levels of 440 genes differing between individuals with and without obesity were no longer different 1 year after surgery, indicating restoration. WGCNA clustered 116 genes with normalized expression in one major module, particularly correlating to weight loss and decreased plasma free fatty acids (FFA), 44 of which showed an obesity-related phenotype upon deletion in mice. Among the genes of the major module, 105 represented prominent markers for reduced FFA concentration, including 55 marker genes for decreased BMI in both the discovery and replication cohorts. CONCLUSIONS: Previously unknown gene networks and marker genes underlined the important role of FFA in restoring muscle gene expression after bariatric surgery and further suggest novel therapeutic targets for obesity.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-7781-8463|https://frl.publisso.de/adhoc/uri/S292YWMsIExlb25h|https://frl.publisso.de/adhoc/uri/R2FuY2hldmEsIFNvZml5YQ==|https://frl.publisso.de/adhoc/uri/SsOkaG5lcnQsIE1hcmt1cw==|https://frl.publisso.de/adhoc/uri/WnVsamFuLCBFcmlrYQ==|https://frl.publisso.de/adhoc/uri/R290dG1hbm4sIFBhc2NhbA==|https://frl.publisso.de/adhoc/uri/S2FobCwgU2FiaW5l|https://frl.publisso.de/adhoc/uri/RGUgQW5nZWxpcywgTWFydGluIEhyYWLElQ==|https://frl.publisso.de/adhoc/uri/Um9kZW4sIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/U2Now7xybWFubiwgQW5uZXR0ZQ==
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6475262.rdf
1000 Erstellt am 2024-04-15T09:33:54.282+0200
1000 Erstellt von 317
1000 beschreibt frl:6475262
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Apr 15 09:35:12 CEST 2024
1000 Objekt bearb. Mon Apr 15 09:35:01 CEST 2024
1000 Vgl. frl:6475262
1000 Oai Id
  1. oai:frl.publisso.de:frl:6475262 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source