Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

  1. Chen, Zhiyang
  2. Amro, Elias Moris
  3. Becker, Friedrich
  4. Hölzer, Martin ORCID logo
  5. Rasa, Seyed Mohammad Mahdi
  6. Njeru, Sospeter Ngoci
  7. Han, Bing
  8. Di Sanzo, Simone
  9. Chen, Yulin
  10. Tang, Duozhuang
  11. Tao, Si
  12. Haenold, Ronny
  13. Groth, Marco ORCID logo
  14. Romanov, Vasily S. ORCID logo
  15. Kirkpatrick, Joanna M.
  16. Kraus, Johann M.
  17. Kestler, Hans A.
  18. Marz, Manja
  19. Ori, Alessandro ORCID logo
  20. Neri, Francesco
  21. Morita, Yohei
  22. Rudolph, Karl Lenhard ORCID logo

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WeightNameValue
1000 Titel
  • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation
1000 Autor/in
  1. Chen, Zhiyang |
  2. Amro, Elias Moris |
  3. Becker, Friedrich |
  4. Hölzer, Martin |
  5. Rasa, Seyed Mohammad Mahdi |
  6. Njeru, Sospeter Ngoci |
  7. Han, Bing |
  8. Di Sanzo, Simone |
  9. Chen, Yulin |
  10. Tang, Duozhuang |
  11. Tao, Si |
  12. Haenold, Ronny |
  13. Groth, Marco |
  14. Romanov, Vasily S. |
  15. Kirkpatrick, Joanna M. |
  16. Kraus, Johann M. |
  17. Kestler, Hans A. |
  18. Marz, Manja |
  19. Ori, Alessandro |
  20. Neri, Francesco |
  21. Morita, Yohei |
  22. Rudolph, Karl Lenhard |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-12-07
1000 Erschienen in
1000 Quellenangabe
  • 216(1):152-175
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1084/jem.20181505 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314529/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies
1000 Sacherschließung
lokal Aging/immunology [MeSH]
lokal Signal Transduction/genetics [MeSH]
lokal Cell Cycle Proteins/genetics [MeSH]
lokal Aging/immunology
lokal Nuclear Proteins/genetics
lokal Phosphoproteins/immunology [MeSH]
lokal Phosphoproteins/genetics [MeSH]
lokal Mice
lokal Signal Transduction/immunology
lokal Phosphoproteins/immunology
lokal Nuclear Proteins/immunology
lokal Inflammation/genetics [MeSH]
lokal Cohesins [MeSH]
lokal NF-kappa B/genetics
lokal Aging/genetics
lokal NF-kappa B/immunology [MeSH]
lokal Inflammation/genetics
lokal Chromosomal Proteins, Non-Histone/genetics
lokal Mice, Knockout
lokal Cell Cycle Proteins/genetics
lokal Cell Cycle Proteins/immunology [MeSH]
lokal Cell Proliferation
lokal Chromosomal Proteins, Non-Histone/immunology
lokal Inflammation/immunology [MeSH]
lokal Phosphoproteins/genetics
lokal Cell Proliferation [MeSH]
lokal DNA-Binding Proteins [MeSH]
lokal Aging/genetics [MeSH]
lokal Signal Transduction/genetics
lokal NF-kappa B/genetics [MeSH]
lokal Animals [MeSH]
lokal Signal Transduction/immunology [MeSH]
lokal Hematopoietic Stem Cells/immunology
lokal Inflammation/immunology
lokal Mice, Knockout [MeSH]
lokal Nuclear Proteins/genetics [MeSH]
lokal Mice [MeSH]
lokal Cohesins
lokal Nuclear Proteins/immunology [MeSH]
lokal Hematopoietic Stem Cells/immunology [MeSH]
lokal Chromosomal Proteins, Non-Histone/genetics [MeSH]
lokal Animals
lokal DNA-Binding Proteins
lokal Chromosomal Proteins, Non-Histone/immunology [MeSH]
lokal NF-kappa B/immunology
lokal Cell Cycle Proteins/immunology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Q2hlbiwgWmhpeWFuZw==|https://frl.publisso.de/adhoc/uri/QW1ybywgRWxpYXMgTW9yaXM=|https://frl.publisso.de/adhoc/uri/QmVja2VyLCBGcmllZHJpY2g=|https://orcid.org/0000-0001-7090-8717|https://frl.publisso.de/adhoc/uri/UmFzYSwgU2V5ZWQgTW9oYW1tYWQgTWFoZGk=|https://frl.publisso.de/adhoc/uri/TmplcnUsIFNvc3BldGVyIE5nb2Np|https://frl.publisso.de/adhoc/uri/SGFuLCBCaW5n|https://frl.publisso.de/adhoc/uri/RGkgU2Fuem8sIFNpbW9uZQ==|https://frl.publisso.de/adhoc/uri/Q2hlbiwgWXVsaW4=|https://frl.publisso.de/adhoc/uri/VGFuZywgRHVvemh1YW5n|https://frl.publisso.de/adhoc/uri/VGFvLCBTaQ==|https://frl.publisso.de/adhoc/uri/SGFlbm9sZCwgUm9ubnk=|https://orcid.org/0000-0002-9199-8990|https://orcid.org/0000-0002-1774-5143|https://frl.publisso.de/adhoc/uri/S2lya3BhdHJpY2ssIEpvYW5uYSBNLg==|https://frl.publisso.de/adhoc/uri/S3JhdXMsIEpvaGFubiBNLg==|https://frl.publisso.de/adhoc/uri/S2VzdGxlciwgSGFucyBBLg==|https://frl.publisso.de/adhoc/uri/TWFyeiwgTWFuamE=|https://orcid.org/0000-0002-3046-0871|https://frl.publisso.de/adhoc/uri/TmVyaSwgRnJhbmNlc2Nv|https://frl.publisso.de/adhoc/uri/TW9yaXRhLCBZb2hlaQ==|https://orcid.org/0000-0002-4839-2862
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1000 Erstellt am 2024-05-08T10:04:49.849+0200
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