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1000
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Abstract/Summary
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<jats:p>Intestinal parasites are a global problem, mainly in developing countries. Obtaining information about plants and compounds that can combat gastrointestinal disorders and gastrointestinal symptoms is a fundamental first step in designing new treatment strategies. In this study, we analyzed the antiamoebic activity of the aerial part of <jats:italic>Croton sonorae</jats:italic>. The dichloromethane fraction of <jats:italic>C. sonorae</jats:italic> (CsDCMfx) contained flavonoids, terpenes, alkaloids, and glycosides. The ultrastructural morphology of the amoebae treated for 72 h with CsDCMfx was completely abnormal. CsDCMfx reduced erythrophagocytosis of trophozoites and the expression of genes involved in erythrocyte adhesion (<jats:italic>gal/galnac lectin</jats:italic>) and actin cytoskeleton rearrangement in the phagocytosis pathway (<jats:italic>rho1 gtpase</jats:italic> and <jats:italic>formin1</jats:italic>). Interestingly, CsDCMfx decreased the expression of genes involved in <jats:italic>Entamoeba histolytica</jats:italic> trophozoite pathogenesis, such as cysteine proteases (<jats:italic>cp1</jats:italic>, <jats:italic>cp4</jats:italic>, and <jats:italic>cp5</jats:italic>), <jats:italic>sod</jats:italic>, <jats:italic>pfor</jats:italic>, and <jats:italic>enolase.</jats:italic> These results showed that <jats:italic>C. sonorae</jats:italic> is a potential source of antiamoebic compounds.</jats:p>
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1000
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Hinweis
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DeepGreen-ID: 425ae73356b0468aa360f6be01e7507a ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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