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1000
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Abstract/Summary
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<jats:p><jats:italic>Mycobacterium tuberculosis (Mtb)</jats:italic> inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which <jats:italic>Mtb</jats:italic> inhibits autophagy are poorly understood. Here, we report a previously unknown mechanism in which <jats:italic>Mtb</jats:italic> phosphoribosyltransferase (<jats:italic>Mtb</jats:italic>PRT) inhibits autophagy in an mTOR, negative regulator of autophagy, independent manner by inducing histone hypermethylation (H3K9me2/3) at the <jats:italic>Atg5</jats:italic> and <jats:italic>Atg7</jats:italic> promoters by activating p38-MAPK- and EHMT2 methyltransferase-dependent signaling pathways. Additionally, we find that <jats:italic>Mtb</jats:italic>PRT induces EZH2 methyltransferase-dependent H3K27me3 hypermethylation and reduces histone acetylation modifications (H3K9ac and H3K27ac) by upregulating histone deacetylase 3 to inhibit autophagy. In summary, this is the first demonstration that <jats:italic>Mtb</jats:italic> inhibits autophagy by inducing histone hypermethylation in autophagy-related genes to promote intracellular bacterial survival.</jats:p>
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1000
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Hinweis
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DeepGreen-ID: 5747aa1251984ab8b21a02e05f78beb1 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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