Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis

  1. gui, Wenfang ORCID logo
  2. Hole, Mikal Jacob
  3. Molinaro, Antonio
  4. Edlund, Karolina ORCID logo
  5. Jørgensen, Kristin K.
  6. Su, Huan
  7. Begher-Tibbe, Brigitte
  8. Gaßler, Nikolaus
  9. Schneider, Carolin V.
  10. Muthukumarasamy, Uthayakumar
  11. Mohs, Antje ORCID logo
  12. Liao, Lijun
  13. Jaeger, Julius ORCID logo
  14. Mertens, Christian Johannes ORCID logo
  15. Bergheim, Ina ORCID logo
  16. Strowig, Till ORCID logo
  17. Hengstler, Jan ORCID logo
  18. Hov, Johannes ORCID logo
  19. Marschall, Hanns-Ulrich ORCID logo
  20. Trautwein, Christian ORCID logo
  21. Schneider , Kai Markus ORCID logo

Download
s41467-023-38840-8-2.pdf 7,59MB
WeightNameValue
1000 Titel
  • Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
1000 Autor/in
  1. gui, Wenfang |
  2. Hole, Mikal Jacob |
  3. Molinaro, Antonio |
  4. Edlund, Karolina |
  5. Jørgensen, Kristin K. |
  6. Su, Huan |
  7. Begher-Tibbe, Brigitte |
  8. Gaßler, Nikolaus |
  9. Schneider, Carolin V. |
  10. Muthukumarasamy, Uthayakumar |
  11. Mohs, Antje |
  12. Liao, Lijun |
  13. Jaeger, Julius |
  14. Mertens, Christian Johannes |
  15. Bergheim, Ina |
  16. Strowig, Till |
  17. Hengstler, Jan |
  18. Hov, Johannes |
  19. Marschall, Hanns-Ulrich |
  20. Trautwein, Christian |
  21. Schneider , Kai Markus |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-06
1000 Erschienen in
1000 Quellenangabe
  • 14(1):3304
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-023-38840-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244448/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-023-38840-8#Sec37 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (IBD), which has been suggested to promote disease development and progression. However, the molecular mechanisms by which intestinal inflammation may aggravate cholestatic liver disease remain incompletely understood. Here, we employ an IBD-PSC mouse model to investigate the impact of colitis on bile acid metabolism and cholestatic liver injury. Unexpectedly, intestinal inflammation and barrier impairment improve acute cholestatic liver injury and result in reduced liver fibrosis in a chronic colitis model. This phenotype is independent of colitis-induced alterations of microbial bile acid metabolism but mediated via hepatocellular NF-κB activation by lipopolysaccharide (LPS), which suppresses bile acid metabolism in-vitro and in-vivo. This study identifies a colitis-triggered protective circuit suppressing cholestatic liver disease and encourages multi-organ treatment strategies for PSC.
1000 Sacherschließung
lokal ulcerative colitis
lokal primary sclerosing cholangitis
lokal mechanisms of disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0009-0006-2317-6959|https://frl.publisso.de/adhoc/uri/SG9sZSwgTWlrYWwgSmFjb2I=|https://frl.publisso.de/adhoc/uri/TW9saW5hcm8sIEFudG9uaW8=|https://orcid.org/0000-0002-0276-2143|https://frl.publisso.de/adhoc/uri/SsO4cmdlbnNlbiwgS3Jpc3RpbiBLLg==|https://frl.publisso.de/adhoc/uri/U3UsIEh1YW4=|https://frl.publisso.de/adhoc/uri/QmVnaGVyLVRpYmJlLCBCcmlnaXR0ZQ==|https://frl.publisso.de/adhoc/uri/R2HDn2xlciwgTmlrb2xhdXM=|https://frl.publisso.de/adhoc/uri/U2NobmVpZGVyLCBDYXJvbGluIFYu|https://frl.publisso.de/adhoc/uri/TXV0aHVrdW1hcmFzYW15LCBVdGhheWFrdW1hcg==|https://orcid.org/0000-0001-5937-0696|https://frl.publisso.de/adhoc/uri/TGlhbywgTGlqdW4=|https://orcid.org/0000-0002-1122-5331|https://orcid.org/0000-0001-7303-2650|https://orcid.org/0000-0002-3356-4115|https://orcid.org/0000-0003-0185-1459|https://orcid.org/0000-0002-1427-5246|https://orcid.org/0000-0002-5900-8096|https://orcid.org/0000-0001-7347-3085|https://orcid.org/0000-0003-2762-8247|https://orcid.org/0000-0002-0047-3794
1000 Label
1000 Förderer
  1. Project DEAL |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Project DEAL |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6483392.rdf
1000 Erstellt am 2024-06-24T11:19:23.046+0200
1000 Erstellt von 254
1000 beschreibt frl:6483392
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Jun 24 12:08:05 CEST 2024
1000 Objekt bearb. Mon Jun 24 12:07:52 CEST 2024
1000 Vgl. frl:6483392
1000 Oai Id
  1. oai:frl.publisso.de:frl:6483392 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source