Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery

  1. Krueger, Johanna
  2. Krauth, Richard
  3. Reichert, Christoph ORCID logo
  4. Perdikis, Serafeim ORCID logo
  5. Vogt, Susanne
  6. Huchtemann, Tessa
  7. Dürschmid, Stefan ORCID logo
  8. Sickert, Almut
  9. Lamprecht, Juliane
  10. Huremovic, Almir
  11. Görtler, Michael
  12. Nasuto, Slawomir J.
  13. Tsai, I.‐Chin
  14. Knight, Robert T.
  15. Hinrichs, Hermann
  16. Heinze, Hans-Jochen
  17. Lindquist, Sabine
  18. Sailer, Michael
  19. Millan, Jose del R. ORCID logo
  20. Sweeney-Reed, Catherine ORCID logo

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1000 Titel
  • Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery
1000 Autor/in
  1. Krueger, Johanna |
  2. Krauth, Richard |
  3. Reichert, Christoph |
  4. Perdikis, Serafeim |
  5. Vogt, Susanne |
  6. Huchtemann, Tessa |
  7. Dürschmid, Stefan |
  8. Sickert, Almut |
  9. Lamprecht, Juliane |
  10. Huremovic, Almir |
  11. Görtler, Michael |
  12. Nasuto, Slawomir J. |
  13. Tsai, I.‐Chin |
  14. Knight, Robert T. |
  15. Hinrichs, Hermann |
  16. Heinze, Hans-Jochen |
  17. Lindquist, Sabine |
  18. Sailer, Michael |
  19. Millan, Jose del R. |
  20. Sweeney-Reed, Catherine |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-08-12
1000 Erschienen in
1000 Quellenangabe
  • 14:18700
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-024-69037-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319604/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-024-69037-8#Sec25 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Functional electrical stimulation (FES) can support functional restoration of a paretic limb post-stroke. Hebbian plasticity depends on temporally coinciding pre- and post-synaptic activity. A tight temporal relationship between motor cortical (MC) activity associated with attempted movement and FES-generated visuo-proprioceptive feedback is hypothesized to enhance motor recovery. Using a brain-computer interface (BCI) to classify MC spectral power in electroencephalographic (EEG) signals to trigger FES-delivery with detection of movement attempts improved motor outcomes in chronic stroke patients. We hypothesized that heightened neural plasticity earlier post-stroke would further enhance corticomuscular functional connectivity and motor recovery. We compared subcortical non-dominant hemisphere stroke patients in BCI-FES and Random-FES (FES temporally independent of MC movement attempt detection) groups. The primary outcome measure was the Fugl-Meyer Assessment, Upper Extremity (FMA-UE). We recorded high-density EEG and transcranial magnetic stimulation-induced motor evoked potentials before and after treatment. The BCI group showed greater: FMA-UE improvement; motor evoked potential amplitude; beta oscillatory power and long-range temporal correlation reduction over contralateral MC; and corticomuscular coherence with contralateral MC. These changes are consistent with enhanced post-stroke motor improvement when movement is synchronized with MC activity reflecting attempted movement.
1000 Sacherschließung
lokal FES
lokal TMS
lokal Acute stroke
lokal Brain–computer interface
lokal FMA
lokal Functional electrical stimulation
lokal Upper limb rehabilitation
lokal Fugl-Meyer assessment
lokal BCI
lokal EEG
lokal Subacute stroke
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S3J1ZWdlciwgSm9oYW5uYQ==|https://frl.publisso.de/adhoc/uri/S3JhdXRoLCBSaWNoYXJk|https://orcid.org/0000-0002-8649-9791|https://orcid.org/0000-0003-2033-2486|https://frl.publisso.de/adhoc/uri/Vm9ndCwgU3VzYW5uZQ==|https://frl.publisso.de/adhoc/uri/SHVjaHRlbWFubiwgVGVzc2E=|https://orcid.org/0000-0001-6686-976X|https://frl.publisso.de/adhoc/uri/U2lja2VydCwgQWxtdXQ=|https://frl.publisso.de/adhoc/uri/TGFtcHJlY2h0LCBKdWxpYW5l|https://frl.publisso.de/adhoc/uri/SHVyZW1vdmljLCBBbG1pcg==|https://frl.publisso.de/adhoc/uri/R8O2cnRsZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/TmFzdXRvLCBTbGF3b21pciBKLg==|https://frl.publisso.de/adhoc/uri/VHNhaSwgSS7igJFDaGlu|https://frl.publisso.de/adhoc/uri/S25pZ2h0LCBSb2JlcnQgVC4=|https://frl.publisso.de/adhoc/uri/SGlucmljaHMsIEhlcm1hbm4=|https://frl.publisso.de/adhoc/uri/SGVpbnplLCBIYW5zLUpvY2hlbg==|https://frl.publisso.de/adhoc/uri/TGluZHF1aXN0LCBTYWJpbmU=|https://frl.publisso.de/adhoc/uri/U2FpbGVyLCBNaWNoYWVs|https://orcid.org/0000-0001-5819-1522|https://orcid.org/0000-0002-3684-1245
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