Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)

  1. Holz, Anja
  2. Obi, Nadia
  3. Ahrens, Wolfgang
  4. Berger, Klaus
  5. Bohn, Barbara
  6. Brenner, Hermann
  7. Fischer, Beate
  8. Fricke, Julia
  9. Führer, Amand
  10. Gastell, Sylvia
  11. Greiser, Karin Halina
  12. Harth, Volker
  13. Heise, Jana-Kristin
  14. Holleczek, Bernd
  15. Keil, Thomas
  16. Klett-Tammen, Carolina J.
  17. Leitzmann, Michael
  18. Lieb, Wolfgang
  19. Meinke-Franze, Claudia
  20. Michels, Karin B.
  21. Mikolajczyk, Rafael
  22. Nimptsch, Katharina
  23. Peters, Annette
  24. Pischon, Tobias
  25. Riedel, Oliver
  26. Schikowski, Tamara
  27. Schipf, Sabine
  28. Schmidt, Börge
  29. Schulze, Matthias B.
  30. Stang, Andreas
  31. Hellwig, Kerstin
  32. Riemann-Lorenz, Karin
  33. Heesen, Christoph
  34. Becher, Heiko

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Holz-et-al_2024_Childhood and adolescence factors.pdf 751,62KB
WeightNameValue
1000 Titel
  • Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)
1000 Autor/in
  1. Holz, Anja |
  2. Obi, Nadia |
  3. Ahrens, Wolfgang |
  4. Berger, Klaus |
  5. Bohn, Barbara |
  6. Brenner, Hermann |
  7. Fischer, Beate |
  8. Fricke, Julia |
  9. Führer, Amand |
  10. Gastell, Sylvia |
  11. Greiser, Karin Halina |
  12. Harth, Volker |
  13. Heise, Jana-Kristin |
  14. Holleczek, Bernd |
  15. Keil, Thomas |
  16. Klett-Tammen, Carolina J. |
  17. Leitzmann, Michael |
  18. Lieb, Wolfgang |
  19. Meinke-Franze, Claudia |
  20. Michels, Karin B. |
  21. Mikolajczyk, Rafael |
  22. Nimptsch, Katharina |
  23. Peters, Annette |
  24. Pischon, Tobias |
  25. Riedel, Oliver |
  26. Schikowski, Tamara |
  27. Schipf, Sabine |
  28. Schmidt, Börge |
  29. Schulze, Matthias B. |
  30. Stang, Andreas |
  31. Hellwig, Kerstin |
  32. Riemann-Lorenz, Karin |
  33. Heesen, Christoph |
  34. Becher, Heiko |
1000 Verlag
  • BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-04-13
1000 Erschienen in
1000 Quellenangabe
  • 24(1):123
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12883-024-03620-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015562/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41–0.56), while overweight (HR 2.03; 95% CI 1.41–2.94) and obesity (HR 1.89; 95% CI 1.02–3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40–0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Multiple Sclerosis
lokal Adult [MeSH]
lokal Adolescence
lokal Humans [MeSH]
lokal Pediatric Obesity [MeSH]
lokal Childhood
lokal Epidemiology
lokal Male [MeSH]
lokal Research
lokal Multiple Sclerosis/epidemiology [MeSH]
lokal Overweight/epidemiology [MeSH]
lokal Exercise [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Universitätsklinikum Hamburg-Eppendorf (UKE) |
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    1000 Förderer Universitätsklinikum Hamburg-Eppendorf (UKE) |
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1000 Erstellt am 2024-10-18T10:29:28.412+0200
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1000 Zuletzt bearbeitet 2025-08-06T14:47:33.941+0200
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