Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem

  1. Kunzler, Angela M.
  2. Iannizzi, Claire
  3. Burns, Jacob
  4. Metzendorf, Maria-Inti
  5. Voigt-Radloff, Sebastian
  6. Piechotta, Vanessa
  7. Schmaderer, Christoph
  8. Holzmann-Littig, Christopher
  9. Balzer, Felix
  10. Benstoem, Carina
  11. Binder, Harald
  12. Boeker, Martin
  13. Dirnagl, Ulrich
  14. Fichtner, Falk
  15. Golinski, Martin
  16. Grundmann, Hajo
  17. Hengel, Hartmut
  18. Jabs, Jonas
  19. Kern, Winfried V.
  20. Kopp, Ina
  21. Kranke, Peter
  22. Kreuzberger, Nina
  23. Laudi, Sven
  24. Lichtner, Gregor
  25. Lieb, Klaus
  26. Maun, Andy
  27. Moerer, Onnen
  28. Müller, Annika
  29. Mutters, Nico T.
  30. Nothacker, Monika
  31. Pfadenhauer, Lisa M.
  32. Popp, Maria
  33. Rüschemeyer, Georg
  34. Schmucker, Christine
  35. Schwingshackl, Lukas
  36. Spies, Claudia
  37. Steckelberg, Anke
  38. Stegemann, Miriam
  39. Strech, Daniel
  40. von Dincklage, Falk
  41. Weibel, Stephanie
  42. Wunderlich, Maximilian Markus
  43. Zöller, Daniela
  44. Rehfuess, Eva
  45. Skoetz, Nicole
  46. Meerpohl, Joerg J.

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1000 Titel
  • Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem
1000 Autor/in
  1. Kunzler, Angela M. |
  2. Iannizzi, Claire |
  3. Burns, Jacob |
  4. Metzendorf, Maria-Inti |
  5. Voigt-Radloff, Sebastian |
  6. Piechotta, Vanessa |
  7. Schmaderer, Christoph |
  8. Holzmann-Littig, Christopher |
  9. Balzer, Felix |
  10. Benstoem, Carina |
  11. Binder, Harald |
  12. Boeker, Martin |
  13. Dirnagl, Ulrich |
  14. Fichtner, Falk |
  15. Golinski, Martin |
  16. Grundmann, Hajo |
  17. Hengel, Hartmut |
  18. Jabs, Jonas |
  19. Kern, Winfried V. |
  20. Kopp, Ina |
  21. Kranke, Peter |
  22. Kreuzberger, Nina |
  23. Laudi, Sven |
  24. Lichtner, Gregor |
  25. Lieb, Klaus |
  26. Maun, Andy |
  27. Moerer, Onnen |
  28. Müller, Annika |
  29. Mutters, Nico T. |
  30. Nothacker, Monika |
  31. Pfadenhauer, Lisa M. |
  32. Popp, Maria |
  33. Rüschemeyer, Georg |
  34. Schmucker, Christine |
  35. Schwingshackl, Lukas |
  36. Spies, Claudia |
  37. Steckelberg, Anke |
  38. Stegemann, Miriam |
  39. Strech, Daniel |
  40. von Dincklage, Falk |
  41. Weibel, Stephanie |
  42. Wunderlich, Maximilian Markus |
  43. Zöller, Daniela |
  44. Rehfuess, Eva |
  45. Skoetz, Nicole |
  46. Meerpohl, Joerg J. |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-07-11
1000 Erschienen in
1000 Quellenangabe
  • 173:111456
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.jclinepi.2024.111456 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES: We present the ‘COVID-19 evidence ecosystem’ (CEOsys) as a German network to inform pandemic management and to support clinical and public health decision-making. We discuss challenges faced when organizing the ecosystem and derive lessons learned for similar networks acting during pandemics or health-related crises. STUDY DESIGN AND SETTING: Bringing together 18 university hospitals and additional institutions, CEOsys key activities included research prioritization, conducting living systematic reviews (LSRs), supporting evidence-based (living) guidelines, knowledge translation (KT), detecting research gaps, and deriving recommendations, backed by technical infrastructure and capacity building. RESULTS: CEOsys rapidly produced 31 high-quality evidence syntheses and supported three living guidelines on COVID-19-related topics, while also developing methodological procedures. Challenges included CEOsys’ late initiation in relation to the pandemic outbreak, the delayed prioritization of research questions, the continuously evolving COVID-19-related evidence, and establishing a technical infrastructure. Methodological-clinical tandems, the cooperation with national guideline groups and international collaborations were key for efficiency. CONCLUSION: CEOsys provided a proof-of-concept for a functioning evidence ecosystem at the national level. Lessons learned include that similar networks should, among others, involve methodological and clinical key stakeholders early on, aim for (inter)national collaborations, and systematically evaluate their value. We particularly call for a sustainable network.
1000 Sacherschließung
lokal Guideline
lokal Systematic review
lokal Pandemic preparedness
lokal COVID-19
lokal Knowledge translation
lokal Evidence ecosystem
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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