Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

  1. Tian, Yu ORCID logo
  2. Lin, Yi
  3. Qu, Conghui
  4. Arndt, Volker ORCID logo
  5. Baurley, James W.
  6. Berndt, Sonja I.
  7. Bien, Stephanie A.
  8. Bishop, Tim ORCID logo
  9. Brenner, Hermann ORCID logo
  10. Buchanan, Daniel ORCID logo
  11. Budiarto, Arif
  12. Campbell, Peter T.
  13. Carreras-Torres, Robert ORCID logo
  14. Casey, Graham
  15. Chan, Andrew ORCID logo
  16. Chen, Rui
  17. Chen, Xuechen ORCID logo
  18. Conti, David ORCID logo
  19. Díez-Obrero, Virginia
  20. Dimou, Niki
  21. Drew, David A.
  22. Figueiredo, Jane C.
  23. Gallinger, Steven
  24. Giles, Graham G.
  25. Gruber, Stephen ORCID logo
  26. Gunter, Marc J.
  27. Harlid, Sophia ORCID logo
  28. Harrison, Tabitha A.
  29. Hidaka, Akihisa
  30. Hoffmeister, Michael ORCID logo
  31. Huyghe, Jeroen ORCID logo
  32. Jenkins, Mark A.
  33. Jordahl, Kristina M.
  34. Joshi, Amit D.
  35. Keku, Temitope O.
  36. Kawaguchi, Eric
  37. Kim, Andre E.
  38. Kundaje, Anshul
  39. Larsson, Susanna ORCID logo
  40. Marchand, Loic Le
  41. Lewinger, Juan Pablo
  42. Li, Li
  43. Moreno, Victor ORCID logo
  44. Morrison, John
  45. Murphy, Neil ORCID logo
  46. Nan, Hongmei
  47. Nassir, Rami ORCID logo
  48. Newcomb, Polly ORCID logo
  49. Obón-Santacana, Mireia
  50. Ogino, Shuji ORCID logo
  51. Ose, Jennifer
  52. Pardamean, Bens ORCID logo
  53. Pellatt, Andrew ORCID logo
  54. Peoples, Anita R.
  55. Platz, Elizabeth ORCID logo
  56. Potter, John D.
  57. Prentice, Ross L.
  58. Rennert, Gad
  59. Ruiz-Narvaez, Edward ORCID logo
  60. Sakoda, Lori C.
  61. Schoen, Robert E.
  62. Shcherbina, Anna
  63. Stern, Mariana C.
  64. Su, Yu-Ru
  65. Thibodeau, Stephen N.
  66. Thomas, Duncan C.
  67. Tsilidis, Konstantinos K.
  68. van Duijnhoven, Franzel J. B.
  69. Van Guelpen, Bethany
  70. Visvanathan, Kala ORCID logo
  71. White, Emily
  72. Wolk, Alicja ORCID logo
  73. Woods, Michael O.
  74. Wu, Anna H.
  75. Peters, Ulrike
  76. Gauderman, W. James
  77. Hsu, Li ORCID logo
  78. Chang-Claude, Jenny ORCID logo

Download
41416_2024_Article_2638.pdf 1,05MB
WeightNameValue
1000 Titel
  • Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
1000 Autor/in
  1. Tian, Yu |
  2. Lin, Yi |
  3. Qu, Conghui |
  4. Arndt, Volker |
  5. Baurley, James W. |
  6. Berndt, Sonja I. |
  7. Bien, Stephanie A. |
  8. Bishop, Tim |
  9. Brenner, Hermann |
  10. Buchanan, Daniel |
  11. Budiarto, Arif |
  12. Campbell, Peter T. |
  13. Carreras-Torres, Robert |
  14. Casey, Graham |
  15. Chan, Andrew |
  16. Chen, Rui |
  17. Chen, Xuechen |
  18. Conti, David |
  19. Díez-Obrero, Virginia |
  20. Dimou, Niki |
  21. Drew, David A. |
  22. Figueiredo, Jane C. |
  23. Gallinger, Steven |
  24. Giles, Graham G. |
  25. Gruber, Stephen |
  26. Gunter, Marc J. |
  27. Harlid, Sophia |
  28. Harrison, Tabitha A. |
  29. Hidaka, Akihisa |
  30. Hoffmeister, Michael |
  31. Huyghe, Jeroen |
  32. Jenkins, Mark A. |
  33. Jordahl, Kristina M. |
  34. Joshi, Amit D. |
  35. Keku, Temitope O. |
  36. Kawaguchi, Eric |
  37. Kim, Andre E. |
  38. Kundaje, Anshul |
  39. Larsson, Susanna |
  40. Marchand, Loic Le |
  41. Lewinger, Juan Pablo |
  42. Li, Li |
  43. Moreno, Victor |
  44. Morrison, John |
  45. Murphy, Neil |
  46. Nan, Hongmei |
  47. Nassir, Rami |
  48. Newcomb, Polly |
  49. Obón-Santacana, Mireia |
  50. Ogino, Shuji |
  51. Ose, Jennifer |
  52. Pardamean, Bens |
  53. Pellatt, Andrew |
  54. Peoples, Anita R. |
  55. Platz, Elizabeth |
  56. Potter, John D. |
  57. Prentice, Ross L. |
  58. Rennert, Gad |
  59. Ruiz-Narvaez, Edward |
  60. Sakoda, Lori C. |
  61. Schoen, Robert E. |
  62. Shcherbina, Anna |
  63. Stern, Mariana C. |
  64. Su, Yu-Ru |
  65. Thibodeau, Stephen N. |
  66. Thomas, Duncan C. |
  67. Tsilidis, Konstantinos K. |
  68. van Duijnhoven, Franzel J. B. |
  69. Van Guelpen, Bethany |
  70. Visvanathan, Kala |
  71. White, Emily |
  72. Wolk, Alicja |
  73. Woods, Michael O. |
  74. Wu, Anna H. |
  75. Peters, Ulrike |
  76. Gauderman, W. James |
  77. Hsu, Li |
  78. Chang-Claude, Jenny |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-04-01
1000 Erschienen in
1000 Quellenangabe
  • 130(10):1687-1696
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41416-024-02638-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091089/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (<jats:italic>p</jats:italic>-value = 2.7 × 10<jats:sup>−8</jats:sup>). At the highest quartile of PRS, the 30-year CRC risk was statistically significantly lower for women taking any MHT than for women not taking any MHT, 3.7% (3.3%–4.0%) vs 6.1% (5.7%–6.5%) (difference 2.4%,<jats:italic>P</jats:italic>-value = 1.83 × 10<jats:sup>−14</jats:sup>); these differences were also statistically significant but smaller in magnitude in the lowest PRS quartile, 1.6% (1.4%–1.8%) vs 2.2% (1.9%–2.4%) (difference 0.6%,<jats:italic>P</jats:italic>-value = 1.01 × 10<jats:sup>−3</jats:sup>), indicating 4 times greater reduction in absolute risk associated with any MHT use in the highest compared to the lowest quartile of genetic CRC risk.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk prediction models for CRC and potentially for the consideration of genetic information in the risk-benefit assessment of MHT use.</jats:p></jats:sec>
1000 Sacherschließung
lokal Genetic Predisposition to Disease [MeSH]
lokal Female [MeSH]
lokal /692/699/67/2324
lokal Aged [MeSH]
lokal Postmenopause [MeSH]
lokal Risk Assessment [MeSH]
lokal Hormone Replacement Therapy/adverse effects [MeSH]
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Risk Factors [MeSH]
lokal Estrogen Replacement Therapy/adverse effects [MeSH]
lokal Colorectal Neoplasms/epidemiology [MeSH]
lokal Menopause [MeSH]
lokal Article
lokal /692/699/67/1504/1885
lokal Colorectal Neoplasms/genetics [MeSH]
lokal Case-Control Studies [MeSH]
lokal /631/208/2489/68
lokal article
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7218-5954|https://frl.publisso.de/adhoc/uri/TGluLCBZaQ==|https://frl.publisso.de/adhoc/uri/UXUsIENvbmdodWk=|https://orcid.org/0000-0001-9320-8684|https://frl.publisso.de/adhoc/uri/QmF1cmxleSwgSmFtZXMgVy4=|https://frl.publisso.de/adhoc/uri/QmVybmR0LCBTb25qYSBJLg==|https://frl.publisso.de/adhoc/uri/QmllbiwgU3RlcGhhbmllIEEu|https://orcid.org/0000-0002-8752-8785|https://orcid.org/0000-0002-6129-1572|https://orcid.org/0000-0003-2225-6675|https://frl.publisso.de/adhoc/uri/QnVkaWFydG8sIEFyaWY=|https://frl.publisso.de/adhoc/uri/Q2FtcGJlbGwsIFBldGVyIFQu|https://orcid.org/0000-0002-2925-734X|https://frl.publisso.de/adhoc/uri/Q2FzZXksIEdyYWhhbQ==|https://orcid.org/0000-0001-7284-6767|https://frl.publisso.de/adhoc/uri/Q2hlbiwgUnVp|https://orcid.org/0000-0003-2476-7110|https://orcid.org/0000-0002-2941-7833|https://frl.publisso.de/adhoc/uri/RMOtZXotT2JyZXJvLCBWaXJnaW5pYQ==|https://frl.publisso.de/adhoc/uri/RGltb3UsIE5pa2k=|https://frl.publisso.de/adhoc/uri/RHJldywgRGF2aWQgQS4=|https://frl.publisso.de/adhoc/uri/RmlndWVpcmVkbywgSmFuZSBDLg==|https://frl.publisso.de/adhoc/uri/R2FsbGluZ2VyLCBTdGV2ZW4=|https://frl.publisso.de/adhoc/uri/R2lsZXMsIEdyYWhhbSBHLg==|https://orcid.org/0000-0001-8656-7822|https://frl.publisso.de/adhoc/uri/R3VudGVyLCBNYXJjIEou|https://orcid.org/0000-0001-8540-6891|https://frl.publisso.de/adhoc/uri/SGFycmlzb24sIFRhYml0aGEgQS4=|https://frl.publisso.de/adhoc/uri/SGlkYWthLCBBa2loaXNh|https://orcid.org/0000-0002-8307-3197|https://orcid.org/0000-0001-6027-9806|https://frl.publisso.de/adhoc/uri/SmVua2lucywgTWFyayBBLg==|https://frl.publisso.de/adhoc/uri/Sm9yZGFobCwgS3Jpc3RpbmEgTS4=|https://frl.publisso.de/adhoc/uri/Sm9zaGksIEFtaXQgRC4=|https://frl.publisso.de/adhoc/uri/S2VrdSwgVGVtaXRvcGUgTy4=|https://frl.publisso.de/adhoc/uri/S2F3YWd1Y2hpLCBFcmlj|https://frl.publisso.de/adhoc/uri/S2ltLCBBbmRyZSBFLg==|https://frl.publisso.de/adhoc/uri/S3VuZGFqZSwgQW5zaHVs|https://orcid.org/0000-0003-0118-0341|https://frl.publisso.de/adhoc/uri/TWFyY2hhbmQsIExvaWMgTGU=|https://frl.publisso.de/adhoc/uri/TGV3aW5nZXIsIEp1YW4gUGFibG8=|https://frl.publisso.de/adhoc/uri/TGksIExp|https://orcid.org/0000-0002-2818-5487|https://frl.publisso.de/adhoc/uri/TW9ycmlzb24sIEpvaG4=|https://orcid.org/0000-0003-3347-8249|https://frl.publisso.de/adhoc/uri/TmFuLCBIb25nbWVp|https://orcid.org/0000-0001-9914-7851|https://orcid.org/0000-0001-8786-0043|https://frl.publisso.de/adhoc/uri/T2LDs24tU2FudGFjYW5hLCBNaXJlaWE=|https://orcid.org/0000-0002-3909-2323|https://frl.publisso.de/adhoc/uri/T3NlLCBKZW5uaWZlcg==|https://orcid.org/0000-0002-7404-9005|https://orcid.org/0000-0002-0127-9790|https://frl.publisso.de/adhoc/uri/UGVvcGxlcywgQW5pdGEgUi4=|https://orcid.org/0000-0003-3676-8954|https://frl.publisso.de/adhoc/uri/UG90dGVyLCBKb2huIEQu|https://frl.publisso.de/adhoc/uri/UHJlbnRpY2UsIFJvc3MgTC4=|https://frl.publisso.de/adhoc/uri/UmVubmVydCwgR2Fk|https://orcid.org/0000-0002-0339-5824|https://frl.publisso.de/adhoc/uri/U2Frb2RhLCBMb3JpIEMu|https://frl.publisso.de/adhoc/uri/U2Nob2VuLCBSb2JlcnQgRS4=|https://frl.publisso.de/adhoc/uri/U2hjaGVyYmluYSwgQW5uYQ==|https://frl.publisso.de/adhoc/uri/U3Rlcm4sIE1hcmlhbmEgQy4=|https://frl.publisso.de/adhoc/uri/U3UsIFl1LVJ1|https://frl.publisso.de/adhoc/uri/VGhpYm9kZWF1LCBTdGVwaGVuIE4u|https://frl.publisso.de/adhoc/uri/VGhvbWFzLCBEdW5jYW4gQy4=|https://frl.publisso.de/adhoc/uri/VHNpbGlkaXMsIEtvbnN0YW50aW5vcyBLLg==|https://frl.publisso.de/adhoc/uri/dmFuIER1aWpuaG92ZW4sIEZyYW56ZWwgSi4gQi4=|https://frl.publisso.de/adhoc/uri/VmFuIEd1ZWxwZW4sIEJldGhhbnk=|https://orcid.org/0000-0002-0582-8005|https://frl.publisso.de/adhoc/uri/V2hpdGUsIEVtaWx5|https://orcid.org/0000-0001-7387-6845|https://frl.publisso.de/adhoc/uri/V29vZHMsIE1pY2hhZWwgTy4=|https://frl.publisso.de/adhoc/uri/V3UsIEFubmEgSC4=|https://frl.publisso.de/adhoc/uri/UGV0ZXJzLCBVbHJpa2U=|https://frl.publisso.de/adhoc/uri/R2F1ZGVybWFuLCBXLiBKYW1lcw==|https://orcid.org/0000-0001-8168-4712|https://orcid.org/0000-0001-8919-1971
1000 Hinweis
  • DeepGreen-ID: 881e24e8b57f494988021778daff64fc ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. National Natural Science Foundation of China |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6503167.rdf
1000 Erstellt am 2025-02-05T19:44:36.552+0100
1000 Erstellt von 322
1000 beschreibt frl:6503167
1000 Zuletzt bearbeitet 2025-09-14T03:54:33.609+0200
1000 Objekt bearb. Sun Sep 14 03:54:33 CEST 2025
1000 Vgl. frl:6503167
1000 Oai Id
  1. oai:frl.publisso.de:frl:6503167 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source