Definition and diagnosis of Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology

  1. Hopfner, Franziska ORCID logo
  2. Höglinger, Günter
  3. German Parkinson’s Guidelines Group
  4. Bähr, Mathias
  5. Becktepe, Jos
  6. Berg, Daniela
  7. Brockmann, Kathrin
  8. Ceballos-Baumann, Andrés
  9. Claßen, Joseph
  10. Deuschl, Cornelius
  11. Deuschl, Günther
  12. Dodel, Richard
  13. Ebersbach, Georg
  14. Eggers, Carsten
  15. van Eimeren, Thilo
  16. Fanciulli, Alessandra
  17. Fimm, Bruno
  18. Folkerts, Ann-Kristin
  19. Gausepohl, Madeleine
  20. Hasan, Alkomiet
  21. Hermann, Wiebke
  22. Hilker-Roggendorf, Rüdiger
  23. Höllerhage, Matthias
  24. Jost, Wolfgang
  25. Kalbe, Elke
  26. Kassubek, Jan
  27. Klebe, Stephan
  28. Klein, Christine
  29. Klietz, Martin
  30. Köglsperger, Thomas
  31. Kühn, Andrea
  32. Krack, Paul
  33. Krismer, Florian
  34. Kuhlenbäumer, Gregor
  35. Levin, Johannes
  36. Liepelt-Scarfone, Inga
  37. Lingor, Paul
  38. Loewenbrück, Kai
  39. Löhle, Matthias
  40. Maaß, Sylvia
  41. Maetzler, Walter
  42. Menzel, Regina
  43. Meyer, Philipp T
  44. Mollenhauer, Brit
  45. Neumann, Manuela
  46. Odin, Per
  47. Outeiro, Tiago
  48. Pötter-Nerger, Monika
  49. Reese, René
  50. Reetz, Kathrin
  51. Rieß, Olaf
  52. Ruf, Viktoria
  53. Schneider, Anja
  54. Schrader, Christoph
  55. Schnitzler, Alfons
  56. Seppi, Klaus
  57. Sixel-Döring, Friederike
  58. Storch, Alexander
  59. Tönges, Lars
  60. Walter, Uwe
  61. Wächter, Tobias
  62. Warnecke, Tobias
  63. Wegner, Florian
  64. Winkler, Christian
  65. Witt, Karsten
  66. Woitalla, Dirk
  67. Zeuner, Kirsten
  68. Trenkwalder, Claudia

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1000 Titel
  • Definition and diagnosis of Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
1000 Autor/in
  1. Hopfner, Franziska |
  2. Höglinger, Günter |
  3. German Parkinson’s Guidelines Group |
  4. Bähr, Mathias |
  5. Becktepe, Jos |
  6. Berg, Daniela |
  7. Brockmann, Kathrin |
  8. Ceballos-Baumann, Andrés |
  9. Claßen, Joseph |
  10. Deuschl, Cornelius |
  11. Deuschl, Günther |
  12. Dodel, Richard |
  13. Ebersbach, Georg |
  14. Eggers, Carsten |
  15. van Eimeren, Thilo |
  16. Fanciulli, Alessandra |
  17. Fimm, Bruno |
  18. Folkerts, Ann-Kristin |
  19. Gausepohl, Madeleine |
  20. Hasan, Alkomiet |
  21. Hermann, Wiebke |
  22. Hilker-Roggendorf, Rüdiger |
  23. Höllerhage, Matthias |
  24. Jost, Wolfgang |
  25. Kalbe, Elke |
  26. Kassubek, Jan |
  27. Klebe, Stephan |
  28. Klein, Christine |
  29. Klietz, Martin |
  30. Köglsperger, Thomas |
  31. Kühn, Andrea |
  32. Krack, Paul |
  33. Krismer, Florian |
  34. Kuhlenbäumer, Gregor |
  35. Levin, Johannes |
  36. Liepelt-Scarfone, Inga |
  37. Lingor, Paul |
  38. Loewenbrück, Kai |
  39. Löhle, Matthias |
  40. Maaß, Sylvia |
  41. Maetzler, Walter |
  42. Menzel, Regina |
  43. Meyer, Philipp T |
  44. Mollenhauer, Brit |
  45. Neumann, Manuela |
  46. Odin, Per |
  47. Outeiro, Tiago |
  48. Pötter-Nerger, Monika |
  49. Reese, René |
  50. Reetz, Kathrin |
  51. Rieß, Olaf |
  52. Ruf, Viktoria |
  53. Schneider, Anja |
  54. Schrader, Christoph |
  55. Schnitzler, Alfons |
  56. Seppi, Klaus |
  57. Sixel-Döring, Friederike |
  58. Storch, Alexander |
  59. Tönges, Lars |
  60. Walter, Uwe |
  61. Wächter, Tobias |
  62. Warnecke, Tobias |
  63. Wegner, Florian |
  64. Winkler, Christian |
  65. Witt, Karsten |
  66. Woitalla, Dirk |
  67. Zeuner, Kirsten |
  68. Trenkwalder, Claudia |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-19
1000 Erschienen in
1000 Quellenangabe
  • 271(11):7102-7119
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-024-12687-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561062/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Accurate definition and operational criteria for diagnosing Parkinson’s disease (PD) are crucial for evidence-based, patient-centered care.</jats:p> </jats:sec><jats:sec> <jats:title>Objective</jats:title> <jats:p>To offer evidence-based recommendations for defining and diagnosing PD, incorporating contemporary clinical, imaging, biomarker, and genetic insights.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The guideline development began with the steering committee establishing key PICO (patient, intervention, comparison, outcome) questions, which were refined by the coauthors. Systematic literature searches identified relevant studies, reviews, and meta-analyses. Recommendations were drafted, evaluated, optimized, and voted upon by the German Parkinson’s Guideline Group.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Parkinson’s disease (PD) is now understood to encompass a broader spectrum of etiologies than previously recognized. Advances in molecular pathogenesis, neuroimaging, and early clinical phenotypes suggest that PD is not a uniform disease entity and is often not idiopathic. This necessitates an updated framework for PD definition and diagnosis. The German Society for Neurology now endorses a broader concept of PD, incorporating both idiopathic and hereditary forms, as opposed to the previously narrower concept of “idiopathic Parkinson syndrome.” The revised guidelines recommend using the 2015 Movement Disorders Society diagnostic criteria, emphasize the importance of long-term clinical follow-up for improved diagnostic accuracy, and highlight the significance of non-motor symptoms in clinical diagnosis. Specific recommendations are provided for the use of imaging and fluid biomarkers and genetic testing to support the clinical diagnosis.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The updated guidelines from the German Society for Neurology enhance diagnostic accuracy for PD, promoting optimized clinical care.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Biomarkers
lokal Systematic Reviews as Topic [MeSH]
lokal Humans [MeSH]
lokal Definition
lokal Practice Guidelines as Topic/standards [MeSH]
lokal Imaging
lokal Parkinson Disease/diagnosis [MeSH]
lokal Neurology/standards [MeSH]
lokal Genetics
lokal Societies, Medical/standards [MeSH]
lokal Germany [MeSH]
lokal Review
lokal Diagnosis
lokal Parkinson’s disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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