Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project

  1. Lange, Berit
  2. Jaeger, Veronika K.
  3. Harries, Manuela
  4. Rücker, Viktoria
  5. Streeck, Hendrik
  6. Blaschke, Sabine
  7. Petersmann, Astrid
  8. Toepfner, Nicole
  9. Nauck, Matthias
  10. Hassenstein, Max J.
  11. Dreier, Maren
  12. von Holt, Isabell
  13. Budde, Axel
  14. Bartz, Antonia
  15. Ortmann, Julia
  16. Kurosinski, Marc-André
  17. Berner, Reinhard
  18. Borsche, Max
  19. Brandhorst, Gunnar
  20. Brinkmann, Melanie
  21. Budde, Kathrin
  22. Deckena, Marek
  23. Engels, Geraldine
  24. Fenzlaff, Marc
  25. Härtel, Christoph
  26. Hovardovska, Olga
  27. Katalinic, Alexander
  28. Kehl, Katja
  29. Kohls, Mirjam
  30. Krüger, Stefan
  31. Lieb, Wolfgang
  32. Meyer-Schlinkmann, Kristin M.
  33. Pischon, Tobias
  34. Rosenkranz, Daniel
  35. Rübsamen, Nicole
  36. Rupp, Jan
  37. Schäfer, Christian
  38. Schattschneider, Mario
  39. Schlegtendal, Anne
  40. Schlinkert, Simon
  41. Schmidbauer, Lena
  42. Schulze-Wundling, Kai
  43. Störk, Stefan
  44. Tiemann, Carsten
  45. Völzke, Henry
  46. Winter, Theresa
  47. Klein, Christine
  48. Liese, Johannes
  49. Brinkmann, Folke
  50. Ottensmeyer, Patrick F.
  51. Reese, Jens-Peter
  52. Heuschmann, Peter
  53. Karch, André

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1000 Titel
  • Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project
1000 Autor/in
  1. Lange, Berit |
  2. Jaeger, Veronika K. |
  3. Harries, Manuela |
  4. Rücker, Viktoria |
  5. Streeck, Hendrik |
  6. Blaschke, Sabine |
  7. Petersmann, Astrid |
  8. Toepfner, Nicole |
  9. Nauck, Matthias |
  10. Hassenstein, Max J. |
  11. Dreier, Maren |
  12. von Holt, Isabell |
  13. Budde, Axel |
  14. Bartz, Antonia |
  15. Ortmann, Julia |
  16. Kurosinski, Marc-André |
  17. Berner, Reinhard |
  18. Borsche, Max |
  19. Brandhorst, Gunnar |
  20. Brinkmann, Melanie |
  21. Budde, Kathrin |
  22. Deckena, Marek |
  23. Engels, Geraldine |
  24. Fenzlaff, Marc |
  25. Härtel, Christoph |
  26. Hovardovska, Olga |
  27. Katalinic, Alexander |
  28. Kehl, Katja |
  29. Kohls, Mirjam |
  30. Krüger, Stefan |
  31. Lieb, Wolfgang |
  32. Meyer-Schlinkmann, Kristin M. |
  33. Pischon, Tobias |
  34. Rosenkranz, Daniel |
  35. Rübsamen, Nicole |
  36. Rupp, Jan |
  37. Schäfer, Christian |
  38. Schattschneider, Mario |
  39. Schlegtendal, Anne |
  40. Schlinkert, Simon |
  41. Schmidbauer, Lena |
  42. Schulze-Wundling, Kai |
  43. Störk, Stefan |
  44. Tiemann, Carsten |
  45. Völzke, Henry |
  46. Winter, Theresa |
  47. Klein, Christine |
  48. Liese, Johannes |
  49. Brinkmann, Folke |
  50. Ottensmeyer, Patrick F. |
  51. Reese, Jens-Peter |
  52. Heuschmann, Peter |
  53. Karch, André |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-08-02
1000 Erschienen in
1000 Quellenangabe
  • 52(1):139-153
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-023-02071-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811028/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected population-based data allowing for the assessment of the protection level in real time.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>In the IMMUNEBRIDGE project, we harmonised data and biosamples for nine population-/hospital-based studies (total number of participants <jats:italic>n</jats:italic> = 33,637) to provide estimates for protection levels against SARS-CoV-2 infection and severe COVID-19 between June and November 2022. Based on evidence synthesis, we formed a combined endpoint of protection levels based on the number of self-reported infections/vaccinations in combination with nucleocapsid/spike antibody responses (“confirmed exposures”). Four confirmed exposures represented the highest protection level, and no exposure represented the lowest.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Most participants were seropositive against the spike antigen; 37% of the participants ≥ 79 years had less than four confirmed exposures (highest level of protection) and 5% less than three. In the subgroup of participants with comorbidities, 46–56% had less than four confirmed exposures. We found major heterogeneity across federal states, with 4–28% of participants having less than three confirmed exposures.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Using serological analyses, literature synthesis and infection dynamics during the survey period, we observed moderate to high levels of protection against severe COVID-19, whereas the protection against SARS-CoV-2 infection was low across all age groups. We found relevant protection gaps in the oldest age group and amongst individuals with comorbidities, indicating a need for additional protective measures in these groups.</jats:p> </jats:sec>
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Seasons [MeSH]
lokal Humans [MeSH]
lokal Humoral immunity
lokal Germany/epidemiology [MeSH]
lokal Antibodies, Viral [MeSH]
lokal Research
lokal Neutralizing antibodies
lokal European People [MeSH]
lokal Seroepidemiological studies
lokal COVID-19/epidemiology [MeSH]
lokal SARS-CoV-2 [MeSH]
lokal SARS-CoV-2
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1000 Liste der Beteiligten
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