Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome

  1. Schnorr, Isabel
  2. Siegl, Anne
  3. Luckhardt, Sonja
  4. Wenz, Söri
  5. Friedrichsen, Hendrik
  6. El Jomaa, Hiba
  7. Steinmann, Annebirth
  8. Kilencz, Tünde
  9. Arteaga-Henríquez, Gara
  10. Ramos-Sayalero, Carolina
  11. Ibanez-Jimenez, Pol
  12. Rosales-Ortiz, Silvia Karina
  13. Bitter, István ORCID logo
  14. Fadeuilhe, Christian
  15. Ferrer, Marc
  16. Lavebratt, Catharina ORCID logo
  17. Réthelyi, János M.
  18. Richarte, Vanesa
  19. Rommelse, Nanda
  20. Ramos-Quiroga, Josep Antoni ORCID logo
  21. Arias-Vasquez, Alejandro ORCID logo
  22. Resch, Eduard
  23. Reif, Andreas ORCID logo
  24. Matura, Silke
  25. Schiweck, Carmen ORCID logo

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1000 Titel
  • Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome
1000 Autor/in
  1. Schnorr, Isabel |
  2. Siegl, Anne |
  3. Luckhardt, Sonja |
  4. Wenz, Söri |
  5. Friedrichsen, Hendrik |
  6. El Jomaa, Hiba |
  7. Steinmann, Annebirth |
  8. Kilencz, Tünde |
  9. Arteaga-Henríquez, Gara |
  10. Ramos-Sayalero, Carolina |
  11. Ibanez-Jimenez, Pol |
  12. Rosales-Ortiz, Silvia Karina |
  13. Bitter, István |
  14. Fadeuilhe, Christian |
  15. Ferrer, Marc |
  16. Lavebratt, Catharina |
  17. Réthelyi, János M. |
  18. Richarte, Vanesa |
  19. Rommelse, Nanda |
  20. Ramos-Quiroga, Josep Antoni |
  21. Arias-Vasquez, Alejandro |
  22. Resch, Eduard |
  23. Reif, Andreas |
  24. Matura, Silke |
  25. Schiweck, Carmen |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-18
1000 Erschienen in
1000 Quellenangabe
  • 14(1):37
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-023-02729-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796401/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>The association between Attention Deficit Hyperactivity Disorder (ADHD) and low-grade inflammation has been explored in children but rarely in adults. Inflammation is characteristic of some, but not all, patients with ADHD and might be influenced by ADHD medication but also lifestyle factors including nutrition, smoking, and stress. It is also still unclear if any specific symptoms are related to inflammation. Therefore, we assessed 96 inflammatory proteins in a deeply phenotyped cohort of 126 adult ADHD participants with a stable medication status using OLINK technology. A data-based, unsupervised hierarchical clustering method could identify two distinct biotypes within the 126 ADHD participants based on their inflammatory profile: a higher inflammatory potential (HIP) and a lower inflammatory protein potential (LIP) group. Biological processes that differed strongest between groups were related to the NF-κB pathway, chemokine signaling, IL-17 signaling, metabolic alterations, and chemokine attraction. A comparison of sample characteristics revealed that the HIP group was more likely to have higher levels of chronic stress (<jats:italic>p</jats:italic> &lt; 0.001), a higher clinical global impression scale score (<jats:italic>p</jats:italic> = 0.030), and a higher risk for suicide (<jats:italic>p</jats:italic> = 0.032). Medication status did not influence protein levels significantly (<jats:italic>p</jats:italic> ≥ 0.074), but psychotropic co-medication (<jats:italic>p</jats:italic> ≤ 0.009) did. In conclusion, our data suggest the presence of two distinct biotypes in adults with ADHD. Higher levels of inflammatory proteins in ADHD are linked to higher levels of chronic perceived stress in a linear fashion. Further research on inflammation in adults with ADHD should take stress levels into account.</jats:p>
1000 Sacherschließung
lokal Attention Deficit Disorder with Hyperactivity/diagnosis [MeSH]
lokal /13/21
lokal /82/80
lokal /692/699/476/1311
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Inflammation [MeSH]
lokal /631/477/2811
lokal /692/53/2421
lokal Smoking [MeSH]
lokal Article
lokal Chemokines/therapeutic use [MeSH]
lokal Proteome [MeSH]
lokal Child [MeSH]
lokal article
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Nobm9yciwgSXNhYmVs|https://frl.publisso.de/adhoc/uri/U2llZ2wsIEFubmU=|https://frl.publisso.de/adhoc/uri/THVja2hhcmR0LCBTb25qYQ==|https://frl.publisso.de/adhoc/uri/V2VueiwgU8O2cmk=|https://frl.publisso.de/adhoc/uri/RnJpZWRyaWNoc2VuLCBIZW5kcmlr|https://frl.publisso.de/adhoc/uri/RWwgSm9tYWEsIEhpYmE=|https://frl.publisso.de/adhoc/uri/U3RlaW5tYW5uLCBBbm5lYmlydGg=|https://frl.publisso.de/adhoc/uri/S2lsZW5jeiwgVMO8bmRl|https://frl.publisso.de/adhoc/uri/QXJ0ZWFnYS1IZW5yw61xdWV6LCBHYXJh|https://frl.publisso.de/adhoc/uri/UmFtb3MtU2F5YWxlcm8sIENhcm9saW5h|https://frl.publisso.de/adhoc/uri/SWJhbmV6LUppbWVuZXosIFBvbA==|https://frl.publisso.de/adhoc/uri/Um9zYWxlcy1PcnRpeiwgU2lsdmlhIEthcmluYQ==|https://orcid.org/0000-0002-9464-4709|https://frl.publisso.de/adhoc/uri/RmFkZXVpbGhlLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/RmVycmVyLCBNYXJj|https://orcid.org/0000-0003-4987-2718|https://frl.publisso.de/adhoc/uri/UsOpdGhlbHlpLCBKw6Fub3MgTS4=|https://frl.publisso.de/adhoc/uri/UmljaGFydGUsIFZhbmVzYQ==|https://frl.publisso.de/adhoc/uri/Um9tbWVsc2UsIE5hbmRh|https://orcid.org/0000-0003-1622-0350|https://orcid.org/0000-0002-4786-0169|https://frl.publisso.de/adhoc/uri/UmVzY2gsIEVkdWFyZA==|https://orcid.org/0000-0002-0992-634X|https://frl.publisso.de/adhoc/uri/TWF0dXJhLCBTaWxrZQ==|https://orcid.org/0000-0003-4215-0448
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