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This lecture was presented at ISHAM 2025 on May 21, 2025, from 13:30 to 14:30. In this session, Dr. Jon Salmanton-García explores the critical role of clinical trials in developing new antifungal therapies. He explains the fundamentals of antifungal clinical research, guiding viewers through each stage of drug development—from preclinical studies to Phase I–III trials. Key topics include trial design, patient populations, clinical endpoints, and the unique challenges in evaluating antifungal efficacy and safety. Dr. Salmanton-García also emphasizes the importance of addressing unmet medical needs, particularly in immunocompromised patients such as those in hematology. The lecture highlights recent advancements and future directions in antifungal treatment, focusing on novel agents, innovative strategies, and the ongoing fight against antifungal resistance—all with the goal of improving clinical outcomes.
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