Structural variation in the pangenome of wild and domesticated barley

  1. Jayakodi, Murukarthick ORCID logo
  2. Lu, Qiongxian ORCID logo
  3. Pidon, Hélène ORCID logo
  4. Rabanus-Wallace, Mark Timothy ORCID logo
  5. Bayer, Micha ORCID logo
  6. Lux, Thomas ORCID logo
  7. Guo, Yu ORCID logo
  8. Jaegle, Benjamin
  9. Badea, Ana
  10. Bekele, Wubishet
  11. Brar, Gurcharn S
  12. Braune, Katarzyna Birch ORCID logo
  13. Bunk, Boyke ORCID logo
  14. Chalmers, Kenneth J
  15. Chapman, Brett ORCID logo
  16. Jørgensen, Morten Egevang ORCID logo
  17. Feng, Jia-Wu ORCID logo
  18. Feser, Manuel ORCID logo
  19. Fiebig, Anne ORCID logo
  20. Gundlach, Heidrun ORCID logo
  21. Guo, Wenbin ORCID logo
  22. Haberer, Georg ORCID logo
  23. Hansson, Mats ORCID logo
  24. Himmelbach, Axel ORCID logo
  25. Hoffie, Iris ORCID logo
  26. Hoffie, Robert Eric ORCID logo
  27. Hu, Haifei
  28. Isobe, Sachiko ORCID logo
  29. König, Patrick ORCID logo
  30. Kale, Sandip ORCID logo
  31. Kamal, Nadia
  32. Keeble-Gagnère, Gabriel
  33. Keller, Beat ORCID logo
  34. Knauft, Manuela
  35. Koppolu, Ravi ORCID logo
  36. Krattinger, Simon ORCID logo
  37. Kumlehn, Jochen ORCID logo
  38. Langridge, Peter ORCID logo
  39. Li, Chengdao ORCID logo
  40. Püpke Marone, Marina ORCID logo
  41. Maurer, Andreas ORCID logo
  42. Mayer, Klaus ORCID logo
  43. Melzer, Michael ORCID logo
  44. Muehlbauer, Gary ORCID logo
  45. Murozuka, Emiko
  46. Padmarasu, Sudharsan ORCID logo
  47. Perovic, Dragan ORCID logo
  48. Pillen, Klaus ORCID logo
  49. Pin, Pierre A
  50. Pozniak, Curtis ORCID logo
  51. Ramsay, Luke ORCID logo
  52. Pedas, Pai Rosager
  53. Rutten, Twan ORCID logo
  54. Sakuma, Shun ORCID logo
  55. Sato, Kazuhiro ORCID logo
  56. Schüler, Danuta ORCID logo
  57. Schmutzer, Thomas ORCID logo
  58. Scholz, Uwe ORCID logo
  59. Schreiber, Miriam ORCID logo
  60. Shirasawa, Kenta ORCID logo
  61. Simpson, Craig ORCID logo
  62. Skadhauge, Birgitte ORCID logo
  63. Spannagl, Manuel ORCID logo
  64. Steffenson, Brian ORCID logo
  65. Thomsen, Hanne C
  66. Tibbits, Josquin ORCID logo
  67. Nielsen, Martin Toft Simmelsgaard
  68. Trautewig, Corinna
  69. Dominique, VEQUAUD ORCID logo
  70. Voss, Cynthia
  71. Wang, Penghao ORCID logo
  72. Waugh, Robbie ORCID logo
  73. Westcott, Sharon
  74. Rasmussen, Magnus ORCID logo
  75. Zhang, Runxuan ORCID logo
  76. Zhang, Xiao-Qi
  77. Wicker, Thomas ORCID logo
  78. Dockter, Christoph ORCID logo
  79. Mascher, Martin ORCID logo
  80. Stein, Nils ORCID logo

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WeightNameValue
1000 Titel
  • Structural variation in the pangenome of wild and domesticated barley
1000 Autor/in
  1. Jayakodi, Murukarthick |
  2. Lu, Qiongxian |
  3. Pidon, Hélène |
  4. Rabanus-Wallace, Mark Timothy |
  5. Bayer, Micha |
  6. Lux, Thomas |
  7. Guo, Yu |
  8. Jaegle, Benjamin |
  9. Badea, Ana |
  10. Bekele, Wubishet |
  11. Brar, Gurcharn S |
  12. Braune, Katarzyna Birch |
  13. Bunk, Boyke |
  14. Chalmers, Kenneth J |
  15. Chapman, Brett |
  16. Jørgensen, Morten Egevang |
  17. Feng, Jia-Wu |
  18. Feser, Manuel |
  19. Fiebig, Anne |
  20. Gundlach, Heidrun |
  21. Guo, Wenbin |
  22. Haberer, Georg |
  23. Hansson, Mats |
  24. Himmelbach, Axel |
  25. Hoffie, Iris |
  26. Hoffie, Robert Eric |
  27. Hu, Haifei |
  28. Isobe, Sachiko |
  29. König, Patrick |
  30. Kale, Sandip |
  31. Kamal, Nadia |
  32. Keeble-Gagnère, Gabriel |
  33. Keller, Beat |
  34. Knauft, Manuela |
  35. Koppolu, Ravi |
  36. Krattinger, Simon |
  37. Kumlehn, Jochen |
  38. Langridge, Peter |
  39. Li, Chengdao |
  40. Püpke Marone, Marina |
  41. Maurer, Andreas |
  42. Mayer, Klaus |
  43. Melzer, Michael |
  44. Muehlbauer, Gary |
  45. Murozuka, Emiko |
  46. Padmarasu, Sudharsan |
  47. Perovic, Dragan |
  48. Pillen, Klaus |
  49. Pin, Pierre A |
  50. Pozniak, Curtis |
  51. Ramsay, Luke |
  52. Pedas, Pai Rosager |
  53. Rutten, Twan |
  54. Sakuma, Shun |
  55. Sato, Kazuhiro |
  56. Schüler, Danuta |
  57. Schmutzer, Thomas |
  58. Scholz, Uwe |
  59. Schreiber, Miriam |
  60. Shirasawa, Kenta |
  61. Simpson, Craig |
  62. Skadhauge, Birgitte |
  63. Spannagl, Manuel |
  64. Steffenson, Brian |
  65. Thomsen, Hanne C |
  66. Tibbits, Josquin |
  67. Nielsen, Martin Toft Simmelsgaard |
  68. Trautewig, Corinna |
  69. Dominique, VEQUAUD |
  70. Voss, Cynthia |
  71. Wang, Penghao |
  72. Waugh, Robbie |
  73. Westcott, Sharon |
  74. Rasmussen, Magnus |
  75. Zhang, Runxuan |
  76. Zhang, Xiao-Qi |
  77. Wicker, Thomas |
  78. Dockter, Christoph |
  79. Mascher, Martin |
  80. Stein, Nils |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-11-13
1000 Erschienen in
1000 Quellenangabe
  • 636(8043):654-662
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1038/s41586-024-08187-1 |
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11655362/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Pangenomes are collections of annotated genome sequences of multiple individuals of a species(1). The structural variants uncovered by these datasets are a major asset to genetic analysis in crop plants(2). Here we report a pangenome of barley comprising long-read sequence assemblies of 76 wild and domesticated genomes and short-read sequence data of 1,315 genotypes. An expanded catalogue of sequence variation in the crop includes structurally complex loci that are rich in gene copy number variation. To demonstrate the utility of the pangenome, we focus on four loci involved in disease resistance, plant architecture, nutrient release and trichome development. Novel allelic variation at a powdery mildew resistance locus and population-specific copy number gains in a regulator of vegetative branching were found. Expansion of a family of starch-cleaving enzymes in elite malting barleys was linked to shifts in enzymatic activity in micro-malting trials. Deletion of an enhancer motif is likely to change the developmental trajectory of the hairy appendages on barley grains. Our findings indicate that allelic diversity at structurally complex loci may have helped crop plants to adapt to new selective regimes in agricultural ecosystems.
1000 Sacherschließung
lokal agricultural genetics
lokal genomics
lokal plant genetics
lokal plant breeding
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-2951-0541|https://orcid.org/0000-0002-1358-2623|https://orcid.org/0000-0002-9802-1787|https://orcid.org/0000-0002-4663-985X|https://orcid.org/0000-0003-0041-3115|https://orcid.org/0000-0002-5543-1911|https://orcid.org/0000-0002-5424-5797|https://frl.publisso.de/adhoc/uri/SmFlZ2xlLCBCZW5qYW1pbg==|https://frl.publisso.de/adhoc/uri/QmFkZWEsIEFuYQ==|https://frl.publisso.de/adhoc/uri/QmVrZWxlLCBXdWJpc2hldA==|https://frl.publisso.de/adhoc/uri/QnJhciwgR3VyY2hhcm4gUw==|https://orcid.org/0000-0001-5390-4079|https://orcid.org/0000-0002-8420-8161|https://frl.publisso.de/adhoc/uri/Q2hhbG1lcnMsIEtlbm5ldGggSg==|https://orcid.org/0000-0003-4484-2253|https://orcid.org/0000-0001-6503-0495|https://orcid.org/0000-0003-3737-4850|https://orcid.org/0000-0001-6546-1818|https://orcid.org/0000-0003-3159-3593|https://orcid.org/0000-0002-6757-0943|https://orcid.org/0000-0002-1829-6044|https://orcid.org/0000-0002-6612-6939|https://orcid.org/0000-0002-0168-9968|https://orcid.org/0000-0001-7338-0946|https://orcid.org/0000-0003-1666-8585|https://orcid.org/0000-0003-1013-6027|https://frl.publisso.de/adhoc/uri/SHUsIEhhaWZlaQ==|https://orcid.org/0000-0002-9555-5054|https://orcid.org/0000-0002-8948-6793|https://orcid.org/0000-0003-0665-5094|https://frl.publisso.de/adhoc/uri/S2FtYWwsIE5hZGlh|https://frl.publisso.de/adhoc/uri/S2VlYmxlLUdhZ27DqHJlLCBHYWJyaWVs|https://orcid.org/0000-0003-2379-9225|https://frl.publisso.de/adhoc/uri/S25hdWZ0LCBNYW51ZWxh|https://orcid.org/0000-0001-8566-9501|https://orcid.org/0000-0001-6912-7411|https://orcid.org/0000-0001-7080-7983|https://orcid.org/0000-0001-9494-400X|https://orcid.org/0000-0002-9653-2700|https://orcid.org/0000-0003-3160-4766|https://orcid.org/0000-0002-2916-7475|https://orcid.org/0000-0001-6484-1077|https://orcid.org/0000-0002-5213-4030|https://orcid.org/0000-0001-9320-2629|https://frl.publisso.de/adhoc/uri/TXVyb3p1a2EsIEVtaWtv|https://orcid.org/0000-0003-3125-3695|https://orcid.org/0000-0002-0292-1693|https://orcid.org/0000-0003-4646-6351|https://frl.publisso.de/adhoc/uri/UGluLCBQaWVycmUgQQ==|https://orcid.org/0000-0002-7536-3856|https://orcid.org/0000-0003-2209-2308|https://frl.publisso.de/adhoc/uri/UGVkYXMsIFBhaSBSb3NhZ2Vy|https://orcid.org/0000-0001-5891-6503|https://orcid.org/0000-0003-1622-5346|https://orcid.org/0000-0001-8818-5203|https://orcid.org/0000-0003-4277-9879|https://orcid.org/0000-0003-1073-6719|https://orcid.org/0000-0001-6113-3518|https://orcid.org/0000-0002-3732-8822|https://orcid.org/0000-0001-7880-6221|https://orcid.org/0000-0002-1723-1492|https://orcid.org/0000-0001-7317-4376|https://orcid.org/0000-0003-0701-7035|https://orcid.org/0000-0001-7961-5363|https://frl.publisso.de/adhoc/uri/VGhvbXNlbiwgSGFubmUgQw==|https://orcid.org/0000-0002-4951-7540|https://frl.publisso.de/adhoc/uri/TmllbHNlbiwgTWFydGluIFRvZnQgU2ltbWVsc2dhYXJkIA==|https://frl.publisso.de/adhoc/uri/VHJhdXRld2lnLCBDb3Jpbm5h|https://orcid.org/0000-0001-7877-6587|https://frl.publisso.de/adhoc/uri/Vm9zcywgQ3ludGhpYQ==|https://orcid.org/0000-0002-3751-3921|https://orcid.org/0000-0003-1045-3065|https://frl.publisso.de/adhoc/uri/V2VzdGNvdHQsIFNoYXJvbg==|https://orcid.org/0000-0001-6720-8832|https://orcid.org/0000-0001-7558-765X|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFhpYW8tUWk=|https://orcid.org/0000-0002-6777-7135|https://orcid.org/0000-0001-5923-3667|https://orcid.org/0000-0001-6373-6013|https://orcid.org/0000-0003-3011-8731
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1000 Dateien
  1. Structural variation in the pangenome of wild and domesticated barley
    Structural variation in the pangenome of wild and domesticated barley
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