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1000 Titel
  • Photon-counting CT-angiography in pre-TAVR aortic annulus assessment: effects of retrospective vs. prospective ECG-synchronization on prosthesis valve selection
1000 Autor/in
  1. Hagar, Muhammad Taha |
  2. Kluemper, Theresa |
  3. Hein, Manuel |
  4. von Zur Muhlen, Constantin |
  5. Faby, Sebastian |
  6. Capilli, Fabio |
  7. Schuppert, Christopher |
  8. Schmitt, Ramona |
  9. Ruile, Philipp |
  10. Westermann, Dirk |
  11. Schlett, Christopher L. |
  12. Bamberg, Fabian |
  13. Krauss, Tobias |
  14. Soschynski, Martin |
1000 Verlag Springer Netherlands
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-02-15
1000 Erschienen in
1000 Quellenangabe
  • 40(4):811-820
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10554-024-03050-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052843/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>To compare the diagnostic value of ultrahigh-resolution CT-angiography (UHR-CTA) compared with high-pitch spiral CTA (HPS-CTA) using a first-generation, dual-source photon-counting CT (PCD-CT) scanner for preprocedural planning of transcatheter aortic valve replacement (TAVR). Clinically referred patients with severe aortic valve stenosis underwent both, retrospective ECG-gated cardiac UHR-CTA (collimation: 120 × 0.2 mm) and prospective ECG-triggered aortoiliac HPS-CTA (collimation: 144 × 0.4 mm, full spectral capabilities) for TAVR planning from August 2022 to March 2023. Radiation dose was extracted from the CT reports, and the effective dose was calculated. Two radiologists analyzed UHR-CTA and HPS-CTA datasets, assessing the image quality of the aortic annulus, with regard to the lumen visibility and margin delineation using a 4-point visual-grading scale (ranges: 4 = ”excellent” to 1 = ”poor”). Aortic annulus area (AAA) measurements were taken for valve prosthesis sizing, with retrospective UHR-CTA serving as reference standard. A total of 64 patients were included (mean age, 81 years ± 7 SD; 28 women) in this retrospective study. HPS-CTA showed a lower radiation dose, 4.1 mSv vs. 12.6 mSv (p &lt; 0.001). UHR-CTA demonstrated higher image quality to HPS-CTA (median score, 4 [IQR, 3–4] vs. 3 [IQR, 2–3]; p &lt; 0.001). Quantitative assessments of AAA from both CTA datasets were strongly positively correlated (mean 477.4 ± 91.1 mm<jats:sup>2</jats:sup> on UHR-CTA and mean 476.5 ± 90.4 mm<jats:sup>2</jats:sup> on HPS-CTA, Pearson r<jats:sup>2</jats:sup> = 0.857, p &lt; 0.001) with a mean error of 22.3 ± 24.6 mm<jats:sup>2</jats:sup> and resulted in identical valve prosthesis sizing in the majority of patients (91%). Patients with lower image quality on HPS-CTA (score value 1 or 2, n = 28) were more likely to receive different sizing recommendations (82%). Both UHR-CTA and HPS-CTA acquisitions using photon-counting CT technology provided reliable aortic annular assessments for TAVR planning. While UHR-CTA offers superior image quality, HPS-CTA is associated with lower radiation exposure. However, severely impaired image quality on HPS-CTA may impact on prosthesis sizing, suggesting that immediate post-scan image evaluations may require complementary UHR-CTA scanning.</jats:p>
1000 Sacherschließung
lokal Aortic Valve/physiopathology [MeSH]
lokal Clinical Decision-Making [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Computed tomography angiography
lokal Aged [MeSH]
lokal Transcatheter Aortic Valve Replacement/instrumentation [MeSH]
lokal Aortic Valve/surgery [MeSH]
lokal Aortic valve stenosis
lokal Photons [MeSH]
lokal Male [MeSH]
lokal Computed Tomography Angiography [MeSH]
lokal Aortic Valve Stenosis/physiopathology [MeSH]
lokal Aortic Valve Stenosis/surgery [MeSH]
lokal Radiation Dosage [MeSH]
lokal Electrocardiography [MeSH]
lokal Prosthesis Design [MeSH]
lokal Aortic Valve Stenosis/diagnostic imaging [MeSH]
lokal Female [MeSH]
lokal Aortic Valve/diagnostic imaging [MeSH]
lokal Humans [MeSH]
lokal Severity of Illness Index [MeSH]
lokal Predictive Value of Tests [MeSH]
lokal Retrospective Studies [MeSH]
lokal Cardiac-Gated Imaging Techniques [MeSH]
lokal Heart Valve Prosthesis [MeSH]
lokal Radiation Exposure [MeSH]
lokal Reproducibility of Results [MeSH]
lokal Original Paper
lokal Multidetector Computed Tomography [MeSH]
lokal Cardiac computed tomography
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9826-2372|https://frl.publisso.de/adhoc/uri/S2x1ZW1wZXIsIFRoZXJlc2E=|https://frl.publisso.de/adhoc/uri/SGVpbiwgTWFudWVs|https://frl.publisso.de/adhoc/uri/dm9uIFp1ciBNdWhsZW4sIENvbnN0YW50aW4=|https://frl.publisso.de/adhoc/uri/RmFieSwgU2ViYXN0aWFu|https://frl.publisso.de/adhoc/uri/Q2FwaWxsaSwgRmFiaW8=|https://frl.publisso.de/adhoc/uri/U2NodXBwZXJ0LCBDaHJpc3RvcGhlcg==|https://frl.publisso.de/adhoc/uri/U2NobWl0dCwgUmFtb25h|https://frl.publisso.de/adhoc/uri/UnVpbGUsIFBoaWxpcHA=|https://frl.publisso.de/adhoc/uri/V2VzdGVybWFubiwgRGlyaw==|https://frl.publisso.de/adhoc/uri/U2NobGV0dCwgQ2hyaXN0b3BoZXIgTC4=|https://frl.publisso.de/adhoc/uri/QmFtYmVyZywgRmFiaWFu|https://frl.publisso.de/adhoc/uri/S3JhdXNzLCBUb2JpYXM=|https://frl.publisso.de/adhoc/uri/U29zY2h5bnNraSwgTWFydGlu
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  1. Baden-Württemberg Ministry of Economic Affairs, Labor and Tourism |
  2. Universitätsklinikum Freiburg |
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    1000 Förderer Universitätsklinikum Freiburg |
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