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1000
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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>Evaluation of distribution kinetics is a neglected aspect of pharmacokinetics. This study examines the utility of the model-independent parameter whole body distribution clearance (<jats:italic>CL</jats:italic><jats:sub><jats:italic>D</jats:italic></jats:sub>) in this respect.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Since mammillary compartmental models are widely used, <jats:italic>CL</jats:italic><jats:sub><jats:italic>D</jats:italic></jats:sub> was calculated in terms of parameters of this model for 15 drugs. The underlying distribution processes were explored by assessment of relationships to pharmacokinetic parameters and covariates.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>The model-independence of the definition of the parameter <jats:italic>CL</jats:italic><jats:sub><jats:italic>D</jats:italic></jats:sub> allowed a comparison of distributional properties of different drugs and provided physiological insight. Significant changes in <jats:italic>CL</jats:italic><jats:sub><jats:italic>D</jats:italic></jats:sub> were observed as a result of drug-drug interactions, transporter polymorphisms and a diseased state.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Total distribution clearance <jats:italic>CL</jats:italic><jats:sub><jats:italic>D</jats:italic></jats:sub> is a useful parameter to evaluate distribution kinetics of drugs. Its estimation as an adjunct to the model-independent parameters clearance and steady-state volume of distribution is advocated.</jats:p>
</jats:sec>
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1000
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Hinweis
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DeepGreen-ID: dde03e48e7c74f29b843260a39ab8495 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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