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1000 Titel
  • Development and validation of a gene expression-based Breast Cancer Purity Score
1000 Autor/in
  1. Barreca, Marco |
  2. Dugo, Matteo |
  3. Galbardi, Barbara |
  4. Győrffy, Balázs |
  5. NA-PHER2 consortium |
  6. Gianni, Luca |
  7. Bisagni, Giancarlo |
  8. Colleoni, Marco |
  9. Del Mastro, Lucia |
  10. Zamagni, Claudio |
  11. Mansutti, Mauro |
  12. Zambetti, Milvia |
  13. Frassoldati, Antonio |
  14. NeoTRIP consortium |
  15. Gianni, Luca |
  16. Montemurro, Filippo |
  17. Zamagni, Claudio |
  18. Del Mastro, Lucia |
  19. Bengala, Carmelo |
  20. Colleoni, Marco |
  21. Mariani, Gabriella |
  22. Gambaro, Anna |
  23. Zambelli, Stefania |
  24. Bianchini, Giampaolo |
  25. Bisagni, Giancarlo |
  26. Russo, Stefania |
  27. Huang, Chiun-Sheng |
  28. Chen, Shou-Tung |
  29. Hou, Ming Feng |
  30. Liu, Liang-Chih |
  31. Tseng, Ling Ming |
  32. Kelly, Catherine |
  33. O’Reilly, Seamus |
  34. Morris, Patrick |
  35. Kennedy, John |
  36. O’Connor, Miriam |
  37. Greil, Richard |
  38. Egle, Daniel |
  39. Thill, Mark |
  40. Sagasser, Jacqueline |
  41. Graffunder, Gerd |
  42. Behringer, Dirk |
  43. Tesch, Hans |
  44. Lück, Hans-Joachim |
  45. Schneeweiss, Andreas |
  46. Schumacher, Claudia |
  47. Malter, Wolfram |
  48. Semiglazov, Vladimir |
  49. Frolova, Mona |
  50. Gennadievich, Alexander Vasiliev |
  51. Volkov, Nikita |
  52. Bermejo, Begoña |
  53. Falo, Catalina |
  54. Sevillano, Elena |
  55. Ciruelos Gil, Eva Maria |
  56. García Sáenz, José Ángel |
  57. Antón-Torres, Anton |
  58. Valagussa, Pinuccia |
  59. Besozzi, Daniela |
  60. Viale, Giuseppe |
  61. Bianchini, Giampaolo |
  62. Gianni, Luca |
  63. Callari, Maurizio |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-10-24
1000 Erschienen in
1000 Quellenangabe
  • 8(1):242
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41698-024-00730-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502849/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The prevalence of malignant cells in clinical specimens, or tumour purity, is affected by both intrinsic biological factors and extrinsic sampling bias. Molecular characterization of large clinical cohorts is typically performed on bulk samples; data analysis and interpretation can be biased by tumour purity variability. Transcription-based strategies to estimate tumour purity have been proposed, but no breast cancer specific method is available yet. We interrogated over 6000 expression profiles from 10 breast cancer datasets to develop and validate a 9-gene Breast Cancer Purity Score (BCPS). BCPS outperformed existing methods for estimating tumour content. Adjusting transcriptomic profiles using the BCPS reduces sampling bias and aids data interpretation. BCPS-estimated tumour purity improved prognostication in luminal breast cancer, correlated with pathologic complete response in on-treatment biopsies from triple-negative breast cancer patients undergoing neoadjuvant treatment and effectively stratified the risk of relapse in HER2+ residual disease post-neoadjuvant treatment.
1000 Sacherschließung
lokal /631/67/1347
lokal Article
lokal /631/67/1857
lokal /631/114
lokal article
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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