A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease

  1. Oltra González, Javier ORCID logo
  2. Segura, Barbara ORCID logo
  3. Strafella, Antonio P.
  4. van Eimeren, Thilo ORCID logo
  5. Ibarretxe-Bilbao, Naroa ORCID logo
  6. Diez Cirarda, Maria ORCID logo
  7. Eggers, Carsten
  8. Lucas-Jiménez, Olaia ORCID logo
  9. Monté-Rubio, Gemma C.
  10. Ojeda, Natalia
  11. Peña, Javier ORCID logo
  12. Ruppert-Junck, Marina Christine ORCID logo
  13. Sala-Llonch, Roser
  14. Theis, Hendrik
  15. Uribe, Carme ORCID logo
  16. Junque, Carme

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1000 Titel
  • A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
1000 Autor/in
  1. Oltra González, Javier |
  2. Segura, Barbara |
  3. Strafella, Antonio P. |
  4. van Eimeren, Thilo |
  5. Ibarretxe-Bilbao, Naroa |
  6. Diez Cirarda, Maria |
  7. Eggers, Carsten |
  8. Lucas-Jiménez, Olaia |
  9. Monté-Rubio, Gemma C. |
  10. Ojeda, Natalia |
  11. Peña, Javier |
  12. Ruppert-Junck, Marina Christine |
  13. Sala-Llonch, Roser |
  14. Theis, Hendrik |
  15. Uribe, Carme |
  16. Junque, Carme |
1000 Verlag
  • Nature Publishing Group UK
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-03-23
1000 Erschienen in
1000 Quellenangabe
  • 10(1):69
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41531-024-00686-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960793/ |
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1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site data.</jats:p>
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lokal Article
lokal /692/308/575
lokal /692/617/375/346/1718
lokal /692/617/375/364
lokal /692/53/2421
lokal article
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  1. https://orcid.org/0000-0002-9268-4504|https://orcid.org/0000-0002-9673-5479|https://frl.publisso.de/adhoc/uri/U3RyYWZlbGxhLCBBbnRvbmlvIFAu|https://orcid.org/0000-0002-6951-2325|https://orcid.org/0000-0002-2434-5252|https://orcid.org/0000-0001-6768-189X|https://frl.publisso.de/adhoc/uri/RWdnZXJzLCBDYXJzdGVu|https://orcid.org/0000-0002-7715-3764|https://frl.publisso.de/adhoc/uri/TW9udMOpLVJ1YmlvLCBHZW1tYSBDLg==|https://frl.publisso.de/adhoc/uri/T2plZGEsIE5hdGFsaWE=|https://orcid.org/0000-0002-0041-7020|https://orcid.org/0000-0002-9025-7058|https://frl.publisso.de/adhoc/uri/U2FsYS1MbG9uY2gsIFJvc2Vy|https://frl.publisso.de/adhoc/uri/VGhlaXMsIEhlbmRyaWs=|https://orcid.org/0000-0002-1415-687X|https://frl.publisso.de/adhoc/uri/SnVucXVlLCBDYXJtZQ==
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