Occupational exposure to chlorinated solvents and lung cancer: results of the SYNERGY case–control study

  1. Wan, Wenxin
  2. Vermeulen, Roel
  3. Portengen, Lützen
  4. Olsson, Ann
  5. Schüz, Joachim
  6. Bijoux, Wendy
  7. Ahrens, Wolfgang
  8. Barul, Christine
  9. Behrens, Thomas
  10. Brüning, Thomas
  11. Caporaso, Neil E.
  12. Consonni, Dario
  13. Demers, Paul A.
  14. Fabianova, Eleonora
  15. Fernández-Tardón, Guilllermo
  16. Field, John
  17. Forastiere, Francesco
  18. Foretova, Lenka
  19. Ge, Calvin B.
  20. Gustavsson, Per
  21. Janout, Vladimir
  22. Jöckel, Karl-Heinz
  23. Karrasch, Stefan
  24. Kendzia, Benjamin
  25. Landi, Maria Teresa
  26. Lissowska, Jolanta
  27. Mates, Dana
  28. McLaughlin, John
  29. Merletti, Franco
  30. Migliore, Enrica
  31. Pándics, Tamás
  32. Pohlabeln, Hermann
  33. Radoï, Loredana
  34. Richiardi, Lorenzo
  35. Schejbalova, Miriam
  36. Siemiatycki, Jack
  37. Świątkowska, Beata
  38. Wichmann, Heinz-Erich
  39. Zaridze, David
  40. Straif, Kurt
  41. Kromhout, Hans
  42. Peters, Susan

WeightNameValue
1000 Titel
  • Occupational exposure to chlorinated solvents and lung cancer: results of the SYNERGY case–control study
1000 Erscheinungsjahr 2026
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2026-03-12
1000 Erschienen in
1000 Quellenangabe
  • 83(1):54-57
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2026
1000 Verlagsversion
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC13271013/ |
  • https://doi.org/10.1136/oemed-2025-110129 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: The association between occupational exposure to chlorinated solvents and lung cancer remains inconclusive. This study investigated this relationship using data from the internationally pooled SYNERGY study. METHODS: Data from 14 case–control studies conducted in 13 European countries and Canada were pooled, including 28 048 participants (12 329 cases and 15 719 controls). Lifetime occupational exposure to chlorinated solvents was assessed using the ALOHA+job-exposure matrix. ORs and 95% CIs were estimated using unconditional logistic regression, adjusted for study centre, age, sex, smoking (pack-years and cessation), cumulative exposure to five occupational lung carcinogens (asbestos, hexavalent chromium, polycyclic aromatic hydrocarbons, respirable crystalline silica and diesel engine exhaust), cumulative benzene exposure and employment in high-risk occupations (‘List A’ jobs). Associations were estimated across categories of exposure levels, durations and analyses stratified by smoking status and lung cancer subtypes. RESULTS: We found no evidence of an association between ever exposure to chlorinated solvents and lung cancer risk (OR 1.03; 95% CI 0.96 to 1.10). Among exposed individuals, a positive trend with cumulative exposure was observed (p=0.031), but not when non-exposed individuals were included (p=0.173). Positive trends were found with exposure duration (p=0.005 for exposed; p=0.048 overall); risks were modestly elevated (OR 1.11) in those exposed for 20 or more years. No increased risk was observed across smoking strata or lung cancer subtypes. CONCLUSIONS: This pooled analysis provides limited evidence of an association between occupational exposure to chlorinated solvents and lung cancer, though exposure-response trends were noted among exposed individuals.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. Deutsche Gesetzliche Unfallversicherung |
1000 Fördernummer
  1. FP 271
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Gesetzliche Unfallversicherung |
    1000 Förderprogramm -
    1000 Fördernummer FP 271
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6529314.rdf
1000 Erstellt am 2026-08-18T13:27:35.285+0200
1000 Erstellt von 266
1000 beschreibt frl:6529314
1000 Bearbeitet von 355
1000 Zuletzt bearbeitet 2026-09-28T21:22:38.377+0200
1000 Objekt bearb. Wed Aug 19 11:06:05 CEST 2026
1000 Vgl. frl:6529314
1000 Oai Id
  1. oai:frl.publisso.de:frl:6529314 |
1000 Sichtbarkeit Metadaten public
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