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WeightNameValue
1000 Titel
  • Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework
1000 Autor/in
  1. Yavari, Fatemeh |
  2. Nitsche, Michael |
  3. Ekhtiari, Hamed |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-04-13
1000 Erschienen in
1000 Quellenangabe
  • 11:159
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fnhum.2017.00159 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390027/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • During recent years, non-invasive brain stimulation, including transcranial electrical stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular, have created new hopes for treatment of neurological and psychiatric diseases. Despite promising primary results in some brain disorders, a more widespread application of tES is hindered by the unsolved question of determining optimum stimulation protocols to receive meaningful therapeutic effects. tES has a large parameter space including various montages and stimulation parameters. Moreover, inter- and intra-individual differences in responding to stimulation protocols have to be taken into account. These factors contribute to the complexity of selecting potentially effective protocols for each disorder, different clusters of each disorder, and even each single patient. Expanding knowledge in different dimensions of basic and clinical neuroscience could help researchers and clinicians to select potentially effective protocols based on tES modulatory mechanisms for future clinical studies. In this article, we propose a heuristic spatiomechanistic framework which contains nine levels to address tES effects on brain functions. Three levels refer to the spatial resolution (local, small-scale networks and large-scale networks) and three levels of tES modulatory effects based on its mechanisms of action (neurochemical, neuroelectrical and oscillatory modulations). At the group level, this framework could be helpful to enable an informed and systematic exploration of various possible protocols for targeting a brain disorder or its neuroscience-based clusters. Considering recent advances in exploration of neurodiversity at the individual level with different brain mapping technologies, the proposed framework might also be used in combination with personal data to design individualized protocols for tES in the context of precision medicine in the future.
1000 Sacherschließung
lokal transcranial electrical stimulation (tES)
lokal montage
lokal individualized
lokal spatiomechanistic
lokal precision medicine
lokal application, protocol
lokal transcranial direct current stimulation (tDCS)
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/WWF2YXJpLCBGYXRlbWVo|http://orcid.org/0000-0002-2207-5965|https://frl.publisso.de/adhoc/creator/RWtodGlhcmksIEhhbWVk
1000 Label
1000 Förderer
  1. European Commission |
  2. German Ministry of Research and Education |
  3. Cognitive Science and Technologies Council of Iran |
  4. Tehran University of Medical Sciences |
  5. Leibniz Association |
1000 Fördernummer
  1. 686764-LUMINOUS
  2. 01EE1403C; 01GQ1424E
  3. -
  4. -
  5. -
1000 Förderprogramm
  1. Horizon 2020 Program, FET Grant
  2. GCBS grant; TRAINSTIM grant
  3. -
  4. -
  5. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Horizon 2020 Program, FET Grant
    1000 Fördernummer 686764-LUMINOUS
  2. 1000 joinedFunding-child
    1000 Förderer German Ministry of Research and Education |
    1000 Förderprogramm GCBS grant; TRAINSTIM grant
    1000 Fördernummer 01EE1403C; 01GQ1424E
  3. 1000 joinedFunding-child
    1000 Förderer Cognitive Science and Technologies Council of Iran |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Tehran University of Medical Sciences |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405701.rdf
1000 Erstellt am 2017-12-06T13:10:28.561+0100
1000 Erstellt von 122
1000 beschreibt frl:6405701
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 21:01:53 CET 2020
1000 Objekt bearb. Tue May 22 07:14:43 CEST 2018
1000 Vgl. frl:6405701
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405701 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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