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1000 Titel
  • Brain activity is contingent on neuropsychological function in a functional magnetic resonance imaging study of verbal working memory in amyotrophic lateral sclerosis
1000 Autor/in
  1. Kobeleva, Xenia |
  2. Machts, Judith |
  3. Veit, Maria |
  4. Vielhaber, Stefan |
  5. Petri, Susanne |
  6. Schoenfeld, Mircea Ariel |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-03
1000 Erschienen in
1000 Quellenangabe
  • 28(9):3051-3060
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/ene.14957 |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/10.1111/ene.14957#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that causes progressive degeneration of neurons in motor and non-motor brain regions, affecting multiple cognitive domains such as memory. A functional magnetic resonance imaging (fMRI) study was performed to explore working memory function in ALS. METHODS: To contribute to the growing research field that employs structural and functional neuroimaging to investigate the effect of ALS on different working memory components, the localization and intensity of alterations in neural activity was explored using fMRI. Being the first study to specifically address verbal working memory via fMRI in the context of ALS, the verbal n-back task with 0-back and 2-back conditions was employed. RESULTS: Despite ALS patients showing unimpaired accuracies (p = 0.724) and reaction times (p = 0.0785), there was significantly increased brain activity of frontotemporal and parietal regions in the 2-back minus 0-back contrast in patients compared to controls (using nonparametric statistics with 5000 permutations and a T threshold of 2.5). DISCUSSION: Increased brain activity of the frontotemporal and parietal regions during working memory performance was largely associated with better neuropsychological function within the ALS group, suggesting a compensatory effect during working memory execution. This study therefore adds to the current knowledge on neural correlates of working memory in ALS and contributes to a more nuanced understanding of hyperactivity during cognitive processes in fMRI studies of ALS.
1000 Sacherschließung
lokal neuroimaging
lokal fMRI
lokal neuropsychology
lokal working memory
lokal amyotrophic lateral sclerosis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7695-1716|https://frl.publisso.de/adhoc/uri/TWFjaHRzLCBKdWRpdGg=|https://frl.publisso.de/adhoc/uri/VmVpdCwgTWFyaWE=|https://frl.publisso.de/adhoc/uri/VmllbGhhYmVyLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/UGV0cmksIFN1c2FubmU=|https://orcid.org/0000-0001-9003-4092
1000 Label
1000 Förderer
  1. State of Saxony-Anhalt |
  2. European Regional Development Fund |
  3. Center for Behavioral Brain Sciences |
  4. German Neuromuscular Society |
  5. Bundesministerium für Bildung und Forschung |
  6. Projekt DEAL |
1000 Fördernummer
  1. -
  2. -
  3. ZS/2016/04/78113
  4. -
  5. -
  6. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. Open Access Funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer State of Saxony-Anhalt |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Regional Development Fund |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Center for Behavioral Brain Sciences |
    1000 Förderprogramm -
    1000 Fördernummer ZS/2016/04/78113
  4. 1000 joinedFunding-child
    1000 Förderer German Neuromuscular Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access Funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6429033.rdf
1000 Erstellt am 2021-08-26T11:31:40.511+0200
1000 Erstellt von 242
1000 beschreibt frl:6429033
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2021-09-09T12:19:40.328+0200
1000 Objekt bearb. Thu Sep 09 12:19:25 CEST 2021
1000 Vgl. frl:6429033
1000 Oai Id
  1. oai:frl.publisso.de:frl:6429033 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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