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1000 Titel
  • Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever: Refinement and Recent Innovations of the Sleeping Beauty Transposon System Enabling Novel, Nonviral Genetic Engineering Applications
1000 Autor/in
  1. Amberger, Maximilian |
  2. Ivics, Zoltan |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-16
1000 Erschienen in
1000 Quellenangabe
  • 42(11):2000136
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/bies.202000136 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The Sleeping Beauty transposon system is a nonviral DNA transfer tool capable of efficiently mediating transposition-based, stable integration of DNA sequences of choice into eukaryotic genomes. Continuous refinements of the system, including the emergence of hyperactive transposase mutants and novel approaches in vectorology, greatly improve upon transposition efficiency rivaling viral-vector-based methods for stable gene insertion. Current developments, such as reversible transgenesis and proof-of-concept RNA-guided transposition, further expand on possible applications in the future. In addition, innate advantages such as lack of preferential integration into genes reduce insertional mutagenesis-related safety concerns while comparably low manufacturing costs enable widespread implementation. Accordingly, the system is recognized as a powerful and versatile tool for genetic engineering and is playing a central role in an ever-expanding number of gene and cell therapy clinical trials with the potential to become a key technology to meet the growing demand for advanced therapy medicinal products.
1000 Sacherschließung
lokal clinical trial
lokal Gentherapie
lokal nonviral
lokal genome engineering
lokal gene therapy
lokal transgenesis
lokal transposition
lokal Sleeping Beauty transposon
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8739-4249|https://orcid.org/0000-0002-7803-6658
1000 Label
1000 Förderer
  1. Horizon 2020 |
  2. Projekt DEAL |
1000 Fördernummer
  1. 754658
  2. -
1000 Förderprogramm
  1. -
  2. Open access funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Horizon 2020 |
    1000 Förderprogramm -
    1000 Fördernummer 754658
  2. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432377.rdf
1000 Erstellt am 2022-03-21T10:54:16.972+0100
1000 Erstellt von 323
1000 beschreibt frl:6432377
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Tue Apr 12 14:00:32 CEST 2022
1000 Objekt bearb. Tue Apr 12 14:00:20 CEST 2022
1000 Vgl. frl:6432377
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432377 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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