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Yuan-et-al_2022_Assessment of Fruit and Vegetables Intake.pdf 787,11KB
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1000 Titel
  • Assessment of Fruit and Vegetables Intake with Biomarkers in Children and Adolescents and Their Level of Validation: A Systematic Review
1000 Autor/in
  1. Yuan, Li |
  2. Muli, Samuel |
  3. Huybrechts, Inge |
  4. Nöthlings, Ute |
  5. Ahrens, Wolfgang |
  6. Scalbert, Augustin |
  7. Floegel, Anna |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-28
1000 Erschienen in
1000 Quellenangabe
  • 12(2):126
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/metabo12020126 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876138/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/2218-1989/12/2/126#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Fruit and vegetables (FV) are part of a healthy diet and should be frequently consumed already at a young age. However, intake of FV is difficult to assess in children and adolescents due to various misreporting aspects. Thus, measurement of dietary biomarkers may be a promising alternative to assess FV intake more objectively at young age. To date, dietary biomarkers have been primarily studied in adults, and research focused on their usefulness in children is scarce. However, clinical studies have revealed important differences between children and adults, most importantly in their gut microbiome composition, resulting in differences in postprandial metabolism, as well as in food choices and meal compositions that may influence individual biomarker levels. Therefore, the present review aimed to identify biomarkers of FV intake (BFVI) currently available in children and adolescents and to explore whether there are any differences in the BFVI profile above between children and adolescents and adults. In addition, the current level of validation of BFVI in children and adolescents was examined. In total, 28 studies were eligible for this review, and 18 compounds were identified as potential biomarkers for FV intake in children and adolescents. Carotenoid concentration in skin was a valuable biomarker for total FV intake for both children and adult populations. Common BFVI in blood in adults (e.g., carotenoids and vitamin C) showed inconsistent results in children and adolescents. Biomarkers particularly useful in children included urinary hippuric acid as a biomarker of polyphenolic compound intake originating from FV and the combination of N-methylnicotinic acid and acetylornithine as a biomarker of bean intake. Further studies are needed to assess their kinetics, dose–response, and other validation aspects. There is limited evidence so far regarding valid BFVI in children and adolescents. Thus, to put BFVI into practice in children and adolescents, further studies, particularly based on metabolomics, are needed to identify and validate BFVI that can be used in future epidemiological studies.
1000 Sacherschließung
lokal Adolescents
lokal Children
lokal Validation
lokal Fruit
lokal Vegetable
lokal Biomarker
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8811-1773|https://frl.publisso.de/adhoc/uri/TXVsaSwgU2FtdWVs|https://orcid.org/0000-0003-3838-855X|https://orcid.org/0000-0002-5789-2252|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0001-6651-6710|https://orcid.org/0000-0001-9806-4288
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Agence Nationale de la Recherche |
  2. Deutsche Forschungsgemeinschaft |
  3. China Scholarship Council |
1000 Fördernummer
  1. -
  2. DFG FL 884/3-1; NO 446/10-1
  3. CSC No. 202009370100
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Agence Nationale de la Recherche |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer DFG FL 884/3-1; NO 446/10-1
  3. 1000 joinedFunding-child
    1000 Förderer China Scholarship Council |
    1000 Förderprogramm -
    1000 Fördernummer CSC No. 202009370100
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6433658.rdf
1000 Erstellt am 2022-05-24T11:24:23.585+0200
1000 Erstellt von 266
1000 beschreibt frl:6433658
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2022-05-25T07:53:29.406+0200
1000 Objekt bearb. Wed May 25 07:52:22 CEST 2022
1000 Vgl. frl:6433658
1000 Oai Id
  1. oai:frl.publisso.de:frl:6433658 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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