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Global Challenges - 2022 - Tian - Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT.pdf 2,17MB
WeightNameValue
1000 Titel
  • Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT
1000 Autor/in
  1. Tian, Hao |
  2. Shi, Hanhan |
  3. Yu, Jie |
  4. Ge, Shengfang |
  5. Ruan, Jing |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-03-20
1000 Erschienen in
1000 Quellenangabe
  • 6(6):2100094
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/gch2.202100094 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Oncological diseases have become the second leading cause of death from noncommunicable diseases worldwide and a major threat to human health. With the continuous progress in cancer research, the mechanical cues from the tumor microenvironment environment (TME) have been found to play an irreplaceable role in the progression of many cancers. As the main extracellular mechanical signal carrier, extracellular matrix (ECM) stiffness may influence cancer progression through biomechanical transduction to modify downstream gene expression, promote epithelial-mesenchymal transition (EMT), and regulate the stemness of cancer cells. EMT is an important mechanism that induces cancer cell metastasis and is closely influenced by ECM stiffness, either independently or in conjunction with other molecules. In this review, the unique role of ECM stiffness in EMT in different kinds of cancers is first summarized. By continually examining the significance of ECM stiffness in cancer progression, a biomimetic culture system based on 3D manufacturing and novel material technologies is developed to mimic ECM stiffness. The authors then look back on the novel development of the ECM stiffness biomimetic culture systems and finally provide new insights into ECM stiffness in cancer progression which can broaden the fields’ horizons with a view toward developing new cancer diagnosis methods and therapies.
1000 Sacherschließung
lokal biomimetic culture system
lokal epithelial‐mesenchymal transition
lokal mechanotransduction
lokal tumor microenvironment
lokal epithelial‐mesenchymal transition stiffness
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VGlhbiwgSGFv|https://frl.publisso.de/adhoc/uri/U2hpLCBIYW5oYW4=|https://frl.publisso.de/adhoc/uri/WXUsIEppZQ==|https://frl.publisso.de/adhoc/uri/R2UsIFNoZW5nZmFuZw==|https://orcid.org/0000-0001-8728-4568
1000 Label
1000 Förderer
  1. National Natural Science Foundation of China |
  2. Shanghai Ninth People's Hospital |
  3. School of Medicine, Shanghai Jiao Tong University |
  4. Shanghai Pujiang Program |
  5. Shanghai Rising-Star Program |
  6. National Key Research and Development Program of China |
  7. Science and Technology Commission of Shanghai Municipality |
  8. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology |
1000 Fördernummer
  1. 81972530, U1932135
  2. -
  3. JYYQ001
  4. 21PJD036
  5. 17QA1402000
  6. 2018YFC1106100, 2018YFC1106101
  7. 20DZ2270800
  8. -
1000 Förderprogramm
  1. -
  2. Fund for Excellent Young Scholars
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
1000 Dateien
  1. Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer 81972530, U1932135
  2. 1000 joinedFunding-child
    1000 Förderer Shanghai Ninth People's Hospital |
    1000 Förderprogramm Fund for Excellent Young Scholars
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer School of Medicine, Shanghai Jiao Tong University |
    1000 Förderprogramm -
    1000 Fördernummer JYYQ001
  4. 1000 joinedFunding-child
    1000 Förderer Shanghai Pujiang Program |
    1000 Förderprogramm -
    1000 Fördernummer 21PJD036
  5. 1000 joinedFunding-child
    1000 Förderer Shanghai Rising-Star Program |
    1000 Förderprogramm -
    1000 Fördernummer 17QA1402000
  6. 1000 joinedFunding-child
    1000 Förderer National Key Research and Development Program of China |
    1000 Förderprogramm -
    1000 Fördernummer 2018YFC1106100, 2018YFC1106101
  7. 1000 joinedFunding-child
    1000 Förderer Science and Technology Commission of Shanghai Municipality |
    1000 Förderprogramm -
    1000 Fördernummer 20DZ2270800
  8. 1000 joinedFunding-child
    1000 Förderer Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6440664.rdf
1000 Erstellt am 2023-03-14T11:03:37.482+0100
1000 Erstellt von 286
1000 beschreibt frl:6440664
1000 Bearbeitet von 286
1000 Zuletzt bearbeitet 2023-03-14T11:05:12.639+0100
1000 Objekt bearb. Tue Mar 14 11:04:44 CET 2023
1000 Vgl. frl:6440664
1000 Oai Id
  1. oai:frl.publisso.de:frl:6440664 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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