HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

  1. Konte, Bettina ORCID logo
  2. Walters, James T. R.
  3. Rujescu, Dan
  4. Legge, Sophie ORCID logo
  5. Pardiñas, Antonio ORCID logo
  6. Cohen, Dan
  7. Pirmohamed, Munir
  8. Tiihonen, Jari ORCID logo
  9. Hartmann, Annette M.
  10. Bogers, Jan ORCID logo
  11. van der Weide, Jan
  12. van der Weide, Karen
  13. Putkonen, Anu
  14. Repo-Tiihonen, Eila
  15. Hallikainen, Tero
  16. Silva, Edward ORCID logo
  17. Ingimarsson, Oddur
  18. Sigurdsson, Engilbert ORCID logo
  19. Kennedy, James ORCID logo
  20. Sullivan, Patrick F ORCID logo
  21. Rietschel, Marcella ORCID logo
  22. Breen, Gerome
  23. Stefansson, Hreinn ORCID logo
  24. Stefansson, Kari
  25. Collier, David ORCID logo
  26. O'Donovan, Michael ORCID logo
  27. Giegling, Ina

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1000 Titel
  • HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry
1000 Autor/in
  1. Konte, Bettina |
  2. Walters, James T. R. |
  3. Rujescu, Dan |
  4. Legge, Sophie |
  5. Pardiñas, Antonio |
  6. Cohen, Dan |
  7. Pirmohamed, Munir |
  8. Tiihonen, Jari |
  9. Hartmann, Annette M. |
  10. Bogers, Jan |
  11. van der Weide, Jan |
  12. van der Weide, Karen |
  13. Putkonen, Anu |
  14. Repo-Tiihonen, Eila |
  15. Hallikainen, Tero |
  16. Silva, Edward |
  17. Ingimarsson, Oddur |
  18. Sigurdsson, Engilbert |
  19. Kennedy, James |
  20. Sullivan, Patrick F |
  21. Rietschel, Marcella |
  22. Breen, Gerome |
  23. Stefansson, Hreinn |
  24. Stefansson, Kari |
  25. Collier, David |
  26. O'Donovan, Michael |
  27. Giegling, Ina |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-12
1000 Erschienen in
1000 Quellenangabe
  • 11(1):214
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01322-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042025/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it does so is largely unknown, but there is evidence for contributing genetic factors. Several studies identified HLA-DQB1 variants and especially a polymorphism located in HLA-DQB1 (6672G>C, rs113332494) as associated with clozapine-induced agranulocytosis and neutropenia. We analysed the risk allele distribution of SNP rs113332494 in a sample of 1396 controls and 178 neutropenia cases of which 60 developed agranulocytosis. Absolute neutrophil counts of 500/mm
1000 Sacherschließung
lokal HLA-DQ beta-Chains/genetics [MeSH]
lokal Neutropenia/chemically induced [MeSH]
lokal Article
lokal Antipsychotic Agents/adverse effects [MeSH]
lokal Humans [MeSH]
lokal Clozapine/adverse effects [MeSH]
lokal Predictive markers
lokal Neutropenia/genetics [MeSH]
lokal Psychiatric disorders
lokal Clinical genetics
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5287-308X|https://frl.publisso.de/adhoc/uri/V2FsdGVycywgSmFtZXMgVC4gUi4=|https://frl.publisso.de/adhoc/uri/UnVqZXNjdSwgRGFu|https://orcid.org/0000-0001-6617-0289|https://orcid.org/0000-0001-6845-7590|https://frl.publisso.de/adhoc/uri/Q29oZW4sIERhbg==|https://frl.publisso.de/adhoc/uri/UGlybW9oYW1lZCwgTXVuaXI=|https://orcid.org/0000-0002-0400-6798|https://frl.publisso.de/adhoc/uri/SGFydG1hbm4sIEFubmV0dGUgTS4=|https://orcid.org/0000-0001-7273-0027|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBXZWlkZSwgSmFu|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBXZWlkZSwgS2FyZW4=|https://frl.publisso.de/adhoc/uri/UHV0a29uZW4sIEFudQ==|https://frl.publisso.de/adhoc/uri/UmVwby1UaWlob25lbiwgRWlsYQ==|https://frl.publisso.de/adhoc/uri/SGFsbGlrYWluZW4sIFRlcm8=|https://orcid.org/0000-0002-7254-6307|https://frl.publisso.de/adhoc/uri/SW5naW1hcnNzb24sIE9kZHVy|https://orcid.org/0000-0001-9404-7982|https://orcid.org/0000-0002-8733-3806|https://orcid.org/0000-0002-6619-873X|https://orcid.org/0000-0002-5236-6149|https://frl.publisso.de/adhoc/uri/QnJlZW4sIEdlcm9tZQ==|https://orcid.org/0000-0002-9331-6666|https://frl.publisso.de/adhoc/uri/U3RlZmFuc3NvbiwgS2FyaQ==|https://orcid.org/0000-0003-4087-1559|https://orcid.org/0000-0001-7073-2379|https://frl.publisso.de/adhoc/uri/R2llZ2xpbmcsIEluYQ==
1000 Hinweis
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1000 Erstellt am 2023-04-26T14:45:44.163+0200
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