Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

  1. Loser, Dominik ORCID logo
  2. Hinojosa, Maria G.
  3. Blum, Jonathan
  4. Schaefer, Jasmin
  5. Brüll, Markus
  6. Johansson, Ylva
  7. Suciu, Ilinca
  8. Grillberger, Karin
  9. Danker, Timm
  10. Möller, Clemens
  11. Gardner, Iain
  12. Ecker, Gerhard F.
  13. Bennekou, Susanne H.
  14. Forsby, Anna
  15. Kraushaar, Udo
  16. Leist, Marcel

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WeightNameValue
1000 Titel
  • Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
1000 Autor/in
  1. Loser, Dominik |
  2. Hinojosa, Maria G. |
  3. Blum, Jonathan |
  4. Schaefer, Jasmin |
  5. Brüll, Markus |
  6. Johansson, Ylva |
  7. Suciu, Ilinca |
  8. Grillberger, Karin |
  9. Danker, Timm |
  10. Möller, Clemens |
  11. Gardner, Iain |
  12. Ecker, Gerhard F. |
  13. Bennekou, Susanne H. |
  14. Forsby, Anna |
  15. Kraushaar, Udo |
  16. Leist, Marcel |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-29
1000 Erschienen in
1000 Quellenangabe
  • 95(6):2081-2107
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-03031-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166715/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signaling. In parallel, we profiled dopaminergic neurons, generated from LUHMES neuronal precursor cells, as novel system to study nAChR activation in human post-mitotic neurons. Changes of the free intracellular Ca
1000 Sacherschließung
lokal Dose-Response Relationship, Drug [MeSH]
lokal Neurotoxicity
lokal Receptors, Nicotinic/drug effects [MeSH]
lokal Calcium/metabolism [MeSH]
lokal Cell Line, Tumor [MeSH]
lokal Neonicotinoids/administration
lokal Humans [MeSH]
lokal In Vitro Systems
lokal Neonicotinoids/toxicity [MeSH]
lokal Cell Line [MeSH]
lokal Nicotine
lokal Live-cell calcium imaging
lokal Desensitization
lokal Neuroblastoma/metabolism [MeSH]
lokal Dopaminergic Neurons/pathology [MeSH]
lokal Signal Transduction/drug effects [MeSH]
lokal Molecular docking
lokal Pesticides/toxicity [MeSH]
lokal Receptors, Nicotinic/metabolism [MeSH]
lokal Dopaminergic Neurons/drug effects [MeSH]
lokal Patch-Clamp Techniques [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2513-238X|https://frl.publisso.de/adhoc/uri/SGlub2pvc2EsIE1hcmlhIEcu|https://frl.publisso.de/adhoc/uri/Qmx1bSwgSm9uYXRoYW4=|https://frl.publisso.de/adhoc/uri/U2NoYWVmZXIsIEphc21pbg==|https://frl.publisso.de/adhoc/uri/QnLDvGxsLCBNYXJrdXM=|https://frl.publisso.de/adhoc/uri/Sm9oYW5zc29uLCBZbHZh|https://frl.publisso.de/adhoc/uri/U3VjaXUsIElsaW5jYQ==|https://frl.publisso.de/adhoc/uri/R3JpbGxiZXJnZXIsIEthcmlu|https://frl.publisso.de/adhoc/uri/RGFua2VyLCBUaW1t|https://frl.publisso.de/adhoc/uri/TcO2bGxlciwgQ2xlbWVucw==|https://frl.publisso.de/adhoc/uri/R2FyZG5lciwgSWFpbg==|https://frl.publisso.de/adhoc/uri/RWNrZXIsIEdlcmhhcmQgRi4=|https://frl.publisso.de/adhoc/uri/QmVubmVrb3UsIFN1c2FubmUgSC4=|https://frl.publisso.de/adhoc/uri/Rm9yc2J5LCBBbm5h|https://frl.publisso.de/adhoc/uri/S3JhdXNoYWFyLCBVZG8=|https://frl.publisso.de/adhoc/uri/TGVpc3QsIE1hcmNlbA==
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1000 Erstellt am 2023-05-11T14:28:55.204+0200
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1000 Zuletzt bearbeitet 2023-10-24T07:31:00.885+0200
1000 Objekt bearb. Tue Oct 24 07:31:00 CEST 2023
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