|
1000
|
Abstract/Summary
|
-
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of hydrogen peroxide [7722‐84‐1] as new inhalation studies are available. Hydrogen peroxide is an irritant to the respiratory tract and the eyes. In a 90‐day inhalation study in the rat a NOAEC of 7 ml/m3 was determined, which confirms the previous 28‐day inhalation study and proves that the effects at the respiratory tract do not increase with exposure duration. A new study of acute effects in volunteers suggests that hydrogen peroxide is slightly irritating at 2.2 ml/m3, but not at 0.5 ml/m3. These findings support all previously described results of inhalation studies in workers or volunteers. Based on the NOAEC established for humans, the MAK value of 0.5 ml/m3 is retained. Peak Limitation Category I and the excursion factor of 1 are retained as there are no new data.
|
